Paraoxon imprinted biopolymer based QCM sensor

Özkütük, Ebru Birlik; Di̇ltemi̇z, Sibel Emi̇r; Özalp, Elif; Gedikbey, Tevfik; Ersöz, Arzu

doi:10.1016/j.matchemphys.2012.12.068

Cited by 27 publications

(13 citation statements)

References 43 publications

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“…They determined 30 minutes to be the saturation time of a pesticide‐imprinted QCM sensor . In another study, the total measurement time of a paraoxon‐imprinted QCM sensor was expressed as 90 minutes . In this study, the total measurement time of the developed QCM sensor was measured as 20 minutes.…”

Section: Resultsmentioning

confidence: 90%

“…QCM is a mass‐sensitive technique based on the piezoelectric effect, which is commonly used as a gravimetric element due to its good mass resolution at a comparatively low operation frequency. The QCM is a simple, easy‐to‐use, cost‐effective, high‐resolution mass‐sensing technique that offers a quick response time and label‐free monitoring in real time; it has been favorably adopted for analytical chemistry and electrochemistry applications due to its sensitive solution‐surface interface measurement capability . Recently, QCM has been well adopted for analytical applications, considering the practical limitations of laboratory‐based methods, such as high cost, long processing times, instrumental complexity, and difficulty of manipulation .…”

Section: Introductionmentioning

confidence: 99%

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A molecularly imprinted nanofilm‐based quartz crystal microbalance sensor for the real‐time detection of pirimicarb

Çakır

2019

J of Molecular Recognition

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This study aimed to prepare a novel quartz crystal microbalance (QCM) sensor for the detection of pirimicarb. Pirimicarb-imprinted poly (ethylene glycol dimethacrylate-Nmetacryloyl-(L)-tryptophan methyl ester) [p (EGDMA-MATrp)] nanofilm (MIP) on the gold surface of a QCM chip was synthesized using the molecular imprinting technique. A nonimprinted p (EGDMA-MATrp) nanofilm (NIP) was also synthesized using the same experimental technique. The MIP and NIP nanofilms were characterized via Fourier transform infrared spectroscopy attenuated total reflectance spectroscopy, contact angle, atomic force microscopy, and an ellipsometer. A competitive adsorption experiment on the sensor was performed to display the selectivity of the nanofilm. An analysis of the QCM sensor showed that the MIP nanofilm exhibited high sensitivity and selectivity for pirimicarb determination. A liquid chromatographytandem mass spectrometry method was prepared and validated to determine the accuracy and precision of the QCM sensor. The accuracy and precision of both methods were determined by a comparison of six replicates at three different concentrations to tomato samples extracted by using a Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method. The limit of detection of the QCM sensor was found to be 0.028 nM. In conclusion, the QCM sensor showed good accuracy, with recovery percentages between 91 and 94%. Also, the pirimicarb-imprinted QCM sensor exhibited a fast response time, reusability, high selectivity and sensitivity, and a low limit of detection. Therefore, it offers a serious alternative to the traditional analytical methods for pesticide detection in both natural sources and aqueous solutions.

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Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

A molecularly imprinted nanofilm‐based quartz crystal microbalance sensor for the real‐time detection of pirimicarb

Çakır

2019

J of Molecular Recognition

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“…The obtained results showed that the prepared QCM sensor-coated MIP film exhibited high affinity toward paraoxon in the concentration range of 0.02 to 1 μM and the limit of detection was found to be 0.02 μM. In another work [61], they used N-(2-aminoethyl)-3-aminopropyltrimethoxysilane–Cu(II) (AAPTS–Cu(II)) as a new metal–chelating monomer and tetraethoxysilane (TEOS) crosslinking agent for the polymerization.…”

Section: Mip Based-quartz Crystal Microbalance (Qcm) Sensorsmentioning

confidence: 92%

Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors

Di̇ltemi̇z

Keçili

Ersöz

et al. 2017

Sensors

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Molecularly imprinted polymers (MIPs) as artificial antibodies have received considerable scientific attention in the past years in the field of (bio)sensors since they have unique features that distinguish them from natural antibodies such as robustness, multiple binding sites, low cost, facile preparation and high stability under extreme operation conditions (higher pH and temperature values, etc.). On the other hand, the Quartz Crystal Microbalance (QCM) is an analytical tool based on the measurement of small mass changes on the sensor surface. QCM sensors are practical and convenient monitoring tools because of their specificity, sensitivity, high accuracy, stability and reproducibility. QCM devices are highly suitable for converting the recognition process achieved using MIP-based memories into a sensor signal. Therefore, the combination of a QCM and MIPs as synthetic receptors enhances the sensitivity through MIP process-based multiplexed binding sites using size, 3D-shape and chemical function having molecular memories of the prepared sensor system toward the target compound to be detected. This review aims to highlight and summarize the recent progress and studies in the field of (bio)sensor systems based on QCMs combined with molecular imprinting technology.

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“…In recent years, a few MIP-based QCM sensors have been developed to detect certain compounds, including albumin, folic acid, paraoxon and so on [19][20][21].…”

Section: Introductionmentioning

confidence: 99%