Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients

Connelly, Philip W.; Maguire, Graham F.; Nash, Michelle M.; Rapi, Lindita; Yan, Andrew T.; Prasad, G. V. Ramesh

doi:10.1155/2012/608580

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…30 In the majority of studies, persons with PON1 R carriers were found to be at increased risk of microvascular and macrovascular complications. [31][32][33] However, Flekac et al (2008) compared diabetic patients with and without DR and found no difference in PON1 phenotype distribution in two groups. 34 The reasons for these discrepancies may be due to differences in type of diabetes, ethnic groups and other genetic contributors.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase1 activity, its Q192R polymorphism and diabetic retinopathy in type 2 diabetes mellitus.

Hampe

Mogarekar²

2014

Int J of Biomed & Adv Res

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Section: Discussionmentioning

confidence: 99%

Paraoxonase1 activity, its Q192R polymorphism and diabetic retinopathy in type 2 diabetes mellitus.

Hampe

Mogarekar²

2014

Int J of Biomed & Adv Res

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“…Measurement of PON1 was an a priori secondary variable. PON1 activity as hydrolysis of phenyl acetate and as enzyme mass were measured as described [16, 17]. PON1 phenotype was determined by the two substrate method of Richter et al [18].…”

Section: Methodsmentioning

confidence: 99%

The increase in paraoxonase-1 is associated with a decrease in left ventricular volume in kidney transplant recipients

Connelly

et al. 2020

Preprint

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Background: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole. Paraoxonase 1 (PON1) is reduced in patients on dialysis, which may be related to their impaired cardiac function. We tested the hypothesis that change in PON1 is associated with changes in left ventricular (LV) end-volume and LV mass after kidney transplantation. Methods: Patients were studied before and 12 months after kidney transplantation. The control group was patients on dialysis not expected to receive a transplant in the next 12 months. Cardiac magnetic resonance imaging was used to measure LV end-diastolic and end-systolic volume and LV mass. PON1 was measured by arylesterase activity and by mass. Results: PON1 mass and activity were not different between the groups at baseline. Both PON1 mass and activity were increased post-kidney transplantation (p<0.0001 for change). The change in PON1 mass (p=0.0062) and PON1 arylesterase activity (p=0.0254) were inversely correlated with the change in NT-proBNP for patients receiving a kidney transplant. However, only the change in the PON1 mass, but not the change in PON1 arylesterase, was inversely correlated with the change in left ventricular volume (ml/m2.7) (p=0.0146 and 0.0114 for diastolic and systolic, respectively) and with the change in hemoglobin (p=0.0042). Conclusions: PON1 mass and activity increase after kidney transplantation. The increase in PON1 mass is consistent with a novel relationship to the increase in hemoglobin and the decrease in LV end-systolic and end-diastolic volume.

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Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1

Saadat

2021

Proceedings of Singapore Healthcare

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Introduction Accumulating evidence recommends that infectious diseases including coronavirus disease 2019 (COVID-19) are often associated with oxidative stress and inflammation. Paraoxonase 1 ( PON1, OMIM: 168,820), a member of the paraoxonase gene family, has antioxidant properties. Enzyme activity of paraoxonase depends on a variety of influencing factors such as polymorphisms of PON1, ethnicity, gender, age, and a number of environmental variables. The PON1 has two common functional polymorphisms, namely, Q192R (rs662) and L55M (rs854560). The R192 and M55 alleles are associated with increase and decrease in enzyme activity, respectively. Objective The present study was conducted to investigate the possible association of rs662 and rs854560 polymorphisms with morbidity and mortality of COVID-19. Methods Data for the prevalence, mortality, and amount of accomplished diagnostic test (per 106 people) on 25 November 2020 from 48 countries were included in the present study. The Human Development Index (HDI) was used as a potential confounding variable. Results The frequency of M55 was positively correlated with the prevalence (partial r = 0.487, df = 36, p = 0.002) and mortality of COVID-19 (partial r = 0.551, df = 36, p < 0.001), after adjustments for HDI and amount of the accomplished diagnostic test as possible confounders. Conclusions This means that countries with higher M55 frequency have higher prevalence and mortality of COVID-19.

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Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients

Cited by 3 publications

References 21 publications

Paraoxonase1 activity, its Q192R polymorphism and diabetic retinopathy in type 2 diabetes mellitus.

Paraoxonase1 activity, its Q192R polymorphism and diabetic retinopathy in type 2 diabetes mellitus.

The increase in paraoxonase-1 is associated with a decrease in left ventricular volume in kidney transplant recipients

Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1

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