Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis

Martinović, Jelena; Kotur‐Stevuljević, Jelena; Dopsaj, Violeta; Dopsaj, Milivoj; Stefanović, Aleksandra; Kasum, Goran

doi:10.1016/j.clinbiochem.2010.07.024

Cited by 6 publications

(9 citation statements)

References 26 publications

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“…However, other studies since have not yet replicated this fi nding ( 78,80 ). Our result that dietary iron supplementation is associated with decreased PON1 levels in human subjects with normal iron homeostasis is not consistent with the Aslan result.…”

Section: Discussioncontrasting

confidence: 55%

“…Moreover, the Aslan report of association between PON1 and iron did not adjust for the potential confounder of impaired hemoglobin synthesis. In a more recent study, it was found that depleted iron stores by itself was not associated with PON1, whereas impaired erythropoiesis resulting from IDA was ( 80 ). Finally, our study was much larger (n = 1,402 versus 25 cases and 22 controls in Aslan et al), with greater power to detect the potentially small change in AREase activity attributed to iron intake.…”

Section: Discussionmentioning

confidence: 91%

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Dietary cholesterol increases paraoxonase 1 enzyme activity

Kim

Burt

Ranchalis

et al. 2012

Journal of Lipid Research

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This article is available online at http://www.jlr.org High density lipoprotein (HDL) levels have long believed to be cardioprotective ( 1 ) through a variety of processes, including reverse cholesterol transport in which excess cholesterol is taken to the liver for excretion ( 2 ). However, recent studies have highlighted the need to better understand the cardioprotective role of HDL. For example, two recent Mendelian randomization studies found that single nucleotide polymorphisms (SNP) that predict plasma HDL cholesterol (HDL-C) variance were not associated with myocardial infarction (MI) ( 3, 4 ). Moreover, a recent drug trial with torcetrapib, a cholesterol ester transport protein inhibitor, found that although torcetrapib increased levels of HDL and lowered deleterious low density lipoprotein (LDL) levels, it did not affect atherosclerotic measures and paradoxically led to an increase in adverse cardiovascular events ( 5 ). In addition, a recent large randomized clinical trial did not show a benefi t of niacin in preventing adverse cardiovascular outcomes, despite improved levels of HDL-C and triglycerides in the treatment group ( 6 ). These results refocus attention on the many aspects of HDL biology that are not captured by serum measurements of HDL, such as its paraoxonase 1 (PON1) activity, which itself is inversely associated with cardiovascular and other human diseases.The activity of PON1 , a liver-produced glycoprotein enzyme bound to the surface of HDL, is consistently correlated with atherosclerotic vascular disease and end-organ damage ( 7-9 ). PON1 is at least partially responsible for the cardioprotective inhibitory effects of HDL on LDL peroxidation ( 10-12 ), and it also has been demonstrated to hydrolyze oxidized lipid or lipid hydroperoxides in LDL ( 13 ). Inactivation of PON1 reduced the ability of HDL to Abstract HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to replicate these fi ndings and determine whether other nutrient intake affected PON1 activity. To predict nutrient and mineral intake values, 1,402 subjects completed a standardized food frequency survey of their dietary habits over the past year. Stepwise regression was used to evaluate dietary and covariate effects on PON1 arylesterase activity. Five dietary components, cholesterol ( P < 2.0 × 10 ؊ 16 ), alcohol ( P = 8.51 × 10 ؊ 8 ), vitamin C ( P = 7.97 × 10 ؊ 5 ), iron ( P = 0.0026), and folic acid (0.037) were independently predictive of PON1 activity. Dietary cholesterol was positively associated and predicted 5.5% of PON1 activity, second in variance explained. This study presents a novel fi nding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confi rms prior reported associations, including that with vitamin C. Identifying and understanding en...

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 91%

Dietary cholesterol increases paraoxonase 1 enzyme activity

Kim

Burt

Ranchalis

et al. 2012

Journal of Lipid Research

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“…Након тога, у наставку процедуре, после одмо-ра од 2 до 3 минута, приступило се мерењу капа-цитета испољавања задате силе (издржљивост ис-пољавања изометријске мишићне силе), односно мерен је временски интервал у којем су испита-ници могли да одржавају задати ниво силе од 50% од максималне, у складу са процедуром описаном раније (Marković et al, 2016). Задатак испитаника је био да гледајући у монитор на коме је приказан ниво силе одржавају дефинисани ниво силе у што дужем временском периоду све до вољног отка-за.…”

Section: процедура мерењаunclassified

Reliability of measuring various contractile functions of finger flexors of men of various ages

Marković¹,

Dopsaj²,

Koropanovski³

et al. 2018

Fizička kultura

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ABSTRACTe aim of the research is to determine the reliability of testing various contractile functions of a male hand based on motoric and functional dominance and age. e examinee takes a seat with their arm extended or mildly exed in a mildly abducted position. For the measuring purposes, dynamometric probe with isometric straining conditions xed to a special construction was used. e "Isometrics" (ver. 3.1.1) was used and frequency of data selection was realized on the level of 500 Hz. e sample includes 269 male examinees aged from 14.0 to 69.9. e results of descriptive statistics have shown that in relation to the tested sample for the non-dominant hand, values for maximum force (F max ) range from 462.8 to 529.0 N, for explosive force (RFD max ) the range is from 1621.6 to 1972.8 N/s and for muscular force impulse (I mp F 50%max ) from 8203.9 to 15552.3 Ns, while F max values the dominant hand ranges from 478.1 to 566.2 N, for RFDmax it ranges from 1742.6 to 2119.0 N/s and for I mp F 50%max 9516.7 to 16845.1 Ns. e results have shown that it is reliable to measure all three examined contractile hand characteristics where by ICC ranges from 0.938 to 0.977 for F max , from 0.903 to 0.971 for RFD max and from 0.747 to 0.943 for I mp F 50%max . e second try as the better result should be considered the representational value for F max and RFD max variables, regardless of the hand dominance or age group. While for the variable I mp F 50%max , in the age groups from 35.0 to 49.9 and from 50.0 to 69.9, the rst tested try for both hands should be considered, in 14.0 to 19.9 years group the second try should be taken into consideration, and in 20.0 to 34.9 age range, the better result of the non-dominant hand is the rst try, and of the dominant is the second try.

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“…e average absolute values of speci c explosive isometric muscle force at the level of 5197.6 N/s -1 and 4040.4 N/s -1 for both hands have been determined by previous study which examined adult trained wrestlers and moderately active subjects (Marković et al, 2016). Based on the comparison of the previous results with the results of this research, it can be argued that cadet judo athletes on the handgrip test achieve results at the level of 88.94% compared to adult wrestlers and 114.42% compared to adult moderately active participants.…”

Section: Resultsmentioning

confidence: 99%

“…Ранијом студијом (Marković et al, 2016) утврђене су просечне апсолутне вредности специфичне експлозивне јачине (силе), испитиване код одра-слих тренираних рвача и умерено активних испи-таника, на нивоу 5197.6 N/s и 4040.4 N/s, за обе шаке збирно. На основу поређења тих резултата са резултатима овог истраживања, може се твр-дити да џудисти кадетског узраста у датом тесту постижу резултате на нивоу 88.94% у односу на одрасле рваче и 114.42% у односу на одрасле уме-рено активне испитанике, што се може тумачити као директан утицај «џудо тренинга».…”

Section: дискусијаunclassified

Explosive isometric muscle force of different muscle groups of cadet judo athletes in function of gender

Marković¹,

Dopsaj²,

Jovanović³

et al. 2018

Fizička kultura

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ABSTRACTe aim of this paper is to determine the di erences in general and speci c explosive isometric muscle force in male and female cadet judo athletes. e results of the measured contractile characteristics were obtained by application of a standardized test battery using the isometric dynamometry method for the following ve muscle groups: exor muscles of the le (ŠL) and the right hand (ŠD), back (MRT) and leg extensor muscles (NOGE) and the ankle joint plantar exor muscles (LIST). e testing included a sample of 14 participants who were competing in the system of individual national championship of the Republic of Serbia for the given age category. On the basis of the obtained results, it can be argued that a general, statistically signi cant, di erence exists between tested judo athletes in the function of gender, both for the absolute values of the variables of basic and speci c explosive isometric muscle force (Wilks' Lambda Value 0.000, F=898.61, p=0.000), as well as between the partialized (relative) values of the measured variables (Wilks' Lambda Value 0.001, F=325.71, p=0.000). e highest level of di erence between male and female athletes in relation to the absolute values of the obtained results was determined for the variables of the speci c explosive isometric muscle force of the le hand exor muscles (RFD max _ŠL, p=0.001), leg extensor muscles (RFD max _NOGE, p=0.003) and right hand exor muscles (RFD max _ŠD, p=0.005). In relation to the relative values obtained by partialization of absolute values in relation to skeletal muscle mass (SMM) the highest level of di erence was determined for variables of speci c isometric explosive muscle force for the le and the right hand, respectively (RFD max _ŠL SMM , p=0.000; RFD max ŠD SMM , p=0.003). e summarized value of the gender dimorphism index (IPD) is at the level of 71.55 and 53.09% for both absolute basic (RFDF max ) and speci c (RFD max ) explosive isometric muscle force, respectively. is indicates that the tested girls reached 71.55% and 53.09% of the given contractile characteristics compared to the tested boys. However, when the measured variables are partialized relative to the skeletal muscle mass (SMM), the fore mentioned di erences are lowered to 101.98% and 71.58%, respectively. On general level, the obtained results have shown that there are methodological indications of scienti c justi cation in relation to the partialization of the results of explosive isometric muscle force as a measure of development of contractile muscle potential directly responsible for the intensive manifestation of muscle force in the unit of time, in relation to skeletal muscle mass.

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Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis

Cited by 6 publications

References 26 publications

Dietary cholesterol increases paraoxonase 1 enzyme activity

Dietary cholesterol increases paraoxonase 1 enzyme activity

Reliability of measuring various contractile functions of finger flexors of men of various ages

Explosive isometric muscle force of different muscle groups of cadet judo athletes in function of gender

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