Paraoxonase activity in two healthy populations with differing rates of coronary heart disease

Abstract

Our results thus provide further support for the hypothesis that populations at increased CHD risk have diminished serum PON1 concentration and an increased prevalence of the R allele of PON1. They are also consistent with reports that the ability of PON1 to hydrolyse paraoxon is inversely related to its capacity to hydrolyse lipid-peroxides, and thus to its antiatherogenic action.

Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: The PRIME study

“…It is possible that subjects from Northern Ireland have lower paraoxonase concentration, as lower HDL concentration could result in lower enzyme mass, but higher specific enzyme activity, i.e. higher activity per unit enzyme, in agreement with the MONICA study [14].…”

“…However, the MONICA study [14] demonstrated that paraoxonase activity was significantly higher in Belfast compared with Toulouse, a finding at odds with those of the PRIME study. One explanation for this difference is that the populations are not directly comparable; approximately 50% of the MONICA populations were female.…”

“…While there is not thought to be a sex-difference in paraoxonase activity [21] it is possible that this may have some bearing on either HDL concentration or paraoxonase enzyme concentration, and thus also paraoxonase activity. Also, as it is not possible to compare demographic data from the MONICA study [14] with that in PRIME, it is impossible to comment on whether there were significant differences between these studies with regard to variables that are likely to alter paraoxonase activity, e.g. diet.…”

“…However, a cross-sectional study has suggested that there is a difference in PON activity between healthy Northern Irish and French populations [14].…”

Estudo das paraoxonases 1, 2 e 3 em pacientes portadores de anemia falciforme"

“…O segundo polimorfismo, na região codificadora do gene da PON, ocorre na posição 55 do gene e afeta, de modo menos intenso e independente quanto ao polimorfismo PON1 192, a atividade da enzima no plasma Mackness et al, 2000). Sabe-se que a presença do alelo 55M está associada à alteração nas concentrações séricas e à baixa eficiência da PON1 plasmática (Costa et al, 2005).…”