Paraoxonase Activity Polymorphism Relationships With Lipid Profiles in a Brazilian Population

Lima, Jonathan D.; Leão, Lucyana Barbosa Cardoso; Rodrigues, Liliane dos Santos; Almeida, Maria Tereza Assis de; Leal, Diana Feio da Veiga Borges

doi:10.1097/01.ede.0000276850.08147.97

Epidemiology

2007

DOI: 10.1097/01.ede.0000276850.08147.97

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Paraoxonase Activity Polymorphism Relationships With Lipid Profiles in a Brazilian Population

Jonathan D. Lima¹,

Lucyana Barbosa Cardoso Leão²,

Liliane dos Santos Rodrigues³

et al.

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Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms are Associated with Type 2 Diabetes Mellitus in Southern Thai Subjects

2020

J Med Assoc Thai

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Background: Paraoxonase 1 (PON1) plays a critical role in the prevention of cardiovascular disease, diabetes mellitus, and other chronic diseases. Objective: The aim of the present study was to investigate the association of PON1 L55M and Q192R polymorphisms with type 2 diabetes mellitus (T2DM), and pre-diabetes. Materials and Methods: The present study included 512 subjects (223 T2DM patients, 150 pre-diabetes, and 139 healthy controls) from Southern Thailand. The PON1 L55M and Q192R polymorphisms were analyzed by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) technique. Results: PON1 Q192R polymorphism showed a statistical difference in genotype frequencies between T2DM patients and healthy controls (p<0.0001). Multiple logistic regression analyses after adjusting for age, gender, and BMI showed that LM and RR genotypes increased the risk for T2DM compared with LL and QQ+QR genotypes (OR 1.96; 95% CI 1.02 to 3.76, p=0.042, and OR 1.85; 95% CI 1.11 to 3.10, p=0.019, respectively). Whereas, QR, genotype was associated with decreased risk for T2DM (OR 0.240; 95% CI 0.13 to 0.45, p<0.0001), and pre-diabetes (OR 0.549; 95% CI 0.30 to 0.99, p=0.048) compared with QQ genotype. Conclusion: PON1 LM and RR genotypes may be genetic risk factors for developing T2DM but QR genotype may prevent T2DM, and pre-diabetes in Southern Thai population. Keywords: PON1, Polymorphisms, Type 2 diabetes, Pre-diabetes

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Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms are Associated with Type 2 Diabetes Mellitus in Southern Thai Subjects

2020

J Med Assoc Thai

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Paraoxonase Activity Polymorphism Relationships With Lipid Profiles in a Brazilian Population

Cited by 1 publication

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Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms are Associated with Type 2 Diabetes Mellitus in Southern Thai Subjects

Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms are Associated with Type 2 Diabetes Mellitus in Southern Thai Subjects

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