Parapapillary atrophy in patients with focal visual field loss

Evaluation of the Structure-Function Relationship in Glaucoma

“…Locations in the superior visual hemifield tend to be most highly correlated with the inferior and slightly temporal area of the ONH (roughly between 5 and 8 o'clock for a right eye); locations in the inferior visual hemifield tend to be most highly correlated with the superior and slightly temporal area of the ONH (between approximately 10 and 12 o'clock for a right eye). This agrees with the results from Emdadi et al 17 A small degree of crossover of the horizontal meridian is apparent; i.e., locations FIGURE 1. The proportion of the total ONH rim area falling into each 10°-wide sector, as averaged over the healthy eyes.…”

“…[11][12][13][14] Iester et al 15 found that the superior and inferior 90°sectors were more informative in predicting visual field loss than the temporal or nasal sectors; Gunderseon et al 16 similarly reported that the polar areas of the ONH were more informative for predicting glaucoma. Emdadi et al 17 found that the neuroretinal rim narrowing in the superior and inferior temporal sectors was associated with glaucoma. However, the aim of these studies was to better identify glaucomatous damage; therefore, they provide only low-resolution maps of the structure-function relationship.…”

Ischemic model of optic nerve injury

“…104 Others have contended that focal ischemia is a clinical form of GON that occurs at all levels of IOP. 105 Local defects in the circulation have also been found in regions of peripapillary atrophy (beta-zone atrophy), 106 and zones of nonperfusion have been demonstrated with fluorescein angiography. 52 Beta-zone peripapillary atrophy is associated with localized neuroretinal rim thinning (focal axonal loss) and progressive glaucomatous damage.…”

Beta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy

“…In general, the reduction in amplitude has been used to identify functional loss due to glaucoma [18, 24], although both amplitude and latency may be affected [24, 27, 28]. Previous studies have reported a significant association between βPPA and VF abnormalities using standard achromatic perimetry (SAP) [29, 30]. There is a positive correlation between the area of βPPA and the severity of the VF global indices (mean deviation, MD and the corrected pattern standard deviation, CPSD) [29].…”

“…Previous studies have reported a significant association between βPPA and VF abnormalities using standard achromatic perimetry (SAP) [29, 30]. There is a positive correlation between the area of βPPA and the severity of the VF global indices (mean deviation, MD and the corrected pattern standard deviation, CPSD) [29]. …”