Paraplegia After Thoracotomy: An Unusual Cause

John, Jiju; Manoj, Padmanabhan; Nair, Suresh; Chandrasekharan, Aluvangal P.; Satyaprasad, Velivela

doi:10.1053/j.jvca.2005.07.037

Cited by 8 publications

(5 citation statements)

References 16 publications

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“… 9 – 12 Additionally, multiple reports have shown granuloma formation and neurological effects associated with the use of some hemostatic agents if not removed. 13 – 19 These observations support the need to develop products that effectively achieve hemostasis in a diverse patient population and introduce minimal safety concerns. An ideal hemostatic agent has the potential to decrease the use of blood products in elective and emergency surgery and demonstrates the ability to manage bleeding from both parenchymal and small or inaccessible arterial and venous structures.…”

Section: Introductionmentioning

confidence: 77%

Safety and effectiveness of a synthetic hemostatic patch for intraoperative soft tissue bleeding

Schuhmacher

Pratschke

Weiß

et al. 2015

MDER

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BackgroundContinuous bleeding after using conventional hemostatic methods involving energy, sutures, or clips, is a serious and costly surgical complication. Many topical agents have been developed to promote intraoperative hemostasis, but improvement is needed in both decreasing time to hemostasis and increasing ease of use. Veriset™ hemostatic patch is CE-marked for controlling bleeding on the liver and in soft tissue. In the current study, we aimed to gather further evidence for the safety and effectiveness of Veriset™ hemostatic patch in soft tissue bleeding during a variety of surgical procedures.MethodsThirty patients scheduled for nonemergency surgery, each with an intraoperative soft tissue bleeding site, were treated with Veriset™ hemostatic patch. Time to hemostasis was monitored, and adverse events were assessed during the 90 days after surgery.ResultsWhen Veriset™ hemostatic patch was used, hemostasis occurred within 5 minutes in 29/30 (96.7%) subjects and within 1 minute in 21/30 (70.0%) subjects. No device-related serious adverse events were recorded during the 30 days after surgery, and no reoperations for device-related bleeding complications were performed during the 5 days after surgery.ConclusionsVeriset™ hemostatic patch is a safe and effective hemostat for controlling soft tissue bleeding during a variety of surgical procedures.

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Section: Introductionmentioning

confidence: 77%

Safety and effectiveness of a synthetic hemostatic patch for intraoperative soft tissue bleeding

Schuhmacher

Pratschke

Weiß

et al. 2015

MDER

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show abstract

“…231 Despite having been used for decades, it is known to cause immune responses and can also cause postoperative neurological complications such as impairment in motor or sensory function of the lower extremities (paraplegia). [232][233][234]…”

Section: Cellulose-based Agentsmentioning

confidence: 99%

Fabrication of Arrays of Polymer Gradients Using Inkjet Printing

Hansen

Zhang

Bradley

2012

Macromol. Rapid Commun.

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Arrays of 84 polymer gradients, fabricated on a single glass microscope slide, were generated by inkjet printing, allowing a combination of high-throughput and true combinatorial methods. The gradual change of composition within the polymer gradients, consisting of two different monomers and a cross-linker, was validated by XPS and fluorescence analysis. Cellular screening of the gradients allowed the rapid identification of optimal polymer compositions for binding of the suspension cell line K562 and the adherent cell line HeLa. The polymers identified were identical to those identified by previous microarray data, providing proof of concept for the successful application of the polymer gradient arrays as a screening tool. In addition, the polymer gradients could be readily modified by conjugation enabling the generation of bio-molecule gradients.

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“…Of particular concern are case reports linking Surgicel ® with postoperative neurological complications. Paraplegia following thoracotomy is the most commonly reported neurological finding21, 51–54. Henry and co‐workers54 cite 14 reports of this problem in addition to their own case report, but also note that this represents an incidence of only 0·08 per cent.…”

Section: Cellulose‐based Haemostatsmentioning

confidence: 99%

“…Henry and co‐workers54 cite 14 reports of this problem in addition to their own case report, but also note that this represents an incidence of only 0·08 per cent. The suggested mechanism is migration of oxidized cellulose from the thoracotomy site through an intervertebral foramen, which is very closely related to the pleural cavity posteriorly52. The neurological complications that follow are thought to be the result of compression of the cord when saturation with blood causes the Surgicel ® to swell51, or direct neurotoxicity resulting from the low pH of Surgicel ® 55.…”

Section: Cellulose‐based Haemostatsmentioning

confidence: 99%

Topical haemostatic agents

Seyednejad

Imani

Jamieson

et al. 2008

British Journal of Surgery

189

167

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Background: A variety of local haemostatic agents is now available to stop troublesome bleeding. These agents are indicated for use during surgical interventions where conventional methods of haemostasis are not applicable because of the site of surgery or the degree of bleeding.Method: A literature search using the PubMed and ISI Web of Knowledge databases identified relevant studies on topical haemostatic agents. Manufacturers' recommendations were also sought through commercial websites.Results and conclusion: A significant body of evidence now exists to support the use of topical haemostatic agents in a wide variety of clinical situations. The advantages and disadvantages of many of these agents are highlighted.

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Paraplegia After Thoracotomy: An Unusual Cause

Cited by 8 publications

References 16 publications

Safety and effectiveness of a synthetic hemostatic patch for intraoperative soft tissue bleeding

Safety and effectiveness of a synthetic hemostatic patch for intraoperative soft tissue bleeding

Fabrication of Arrays of Polymer Gradients Using Inkjet Printing

Topical haemostatic agents

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