Paraplegia due to osteitis fibrosa secondary to primary hyperparathyroidism: Report of a case

Sarda, A. K.; Arunabh,; Vijayaraghavan, M; Kapur, M. M.

doi:10.1007/bf00308978

Cited by 19 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D deficiency, osteomalacia, and osteoporosis are common findings in developing countries and when compounded by primary HPT, become a diagnostic challenge and a cause of apparent normocalcemic HPT. The majority of patients with normocalcemic primary HPT have a history of urinary tract stone and/or hypercalciuria, but brown tumor without renal calculi also occur in these patients (8,19,24), as was observed in our patients.…”

supporting

confidence: 53%

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Khalatbari¹,

Hamidi²,

Moharamzad³

et al. 2011

Turkish Neurosurgery

View full text Add to dashboard Cite

Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. Skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is very uncommon and brown tumor has become extremely a rare clinical entity. Hyperparathyroidism is usually associated with high levels of serum calcium. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare. Moreover, involvement of the skull base and the orbit is exceedingly rare. The authors would report three cases of brown tumor of the anterior skull base that were associated with true normocalcemic primary hyperparathyroidism. Clinical manifestations, neuroimaging findings, pathological findings, diagnosis and treatment of the patients are discussed and the relevant literature is reviewed. KeywoRds: Brown tumor, Skull base, Normocalcemia, Primary hyperparathyroidism ÖZKahverengi tümör çeşitli etiyolojiler nedenli hiperparatiroidiye sekonder bir kemik lezyonudur. Paratiroid adenomuna sekonder primer hiperparatiroidide iskelet tutulumu çok nadirdir ve kahverengi tümör çok nadir bir klinik olay haline gelmiştir. Hiperparatiroidi genellikle yüksek serum kalsiyum düzeyleriyle ilişkilidir. Normokalsemik primer hiperparatiroidinin tek ve başlangıç belirtisi olarak kahverengi tümör çok nadirdir. Ayrıca kafatası tabanı ve orbitanın tutulması son derece nadirdir. Yazarlar gerçek normokalsemik primer paratiroidi ile ilişkili anterior kafatası tabanının üç kahverengi tümör vakasını sunmaktadır. Klinik bulgular, nörogörüntüleme bulguları, patolojik bulgular ve bu hastaların tanı ve tedavisi sunulmakta ve ilgili literatür gözden geçirilmektedir.

show abstract

supporting

confidence: 53%

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Khalatbari¹,

Hamidi²,

Moharamzad³

et al. 2011

Turkish Neurosurgery

View full text Add to dashboard Cite

show abstract

“…BTs are localized form of osteitis fibrosa cystica (OFC) that is commonly associated with hyperparathyroidism. OFC is a process that is characterized by hyperstimulation of osteoclastic proliferation via longstanding excessive PTH production causing bone resorption and bone marrow fibrosis 3 7 10 14) .…”

Section: Discussionmentioning

confidence: 99%

“…The symptoms of spinal BTs include axial pain, radiculopathy, myelopathy and myeloradiculopathy according to their locations 1 3 12 13 14 15 16 17 18 19 20) . Radiographically, BTs do not have a pathognomonic appearance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brown Tumor of the Thoracic Spine: First Manifestation of Primary Hyperparathyroidism

Sonmez

Tezcaner

Çöven

et al. 2015

J Korean Neurosurg Soc

View full text Add to dashboard Cite

Brown tumors also called as osteoclastomas, are rare nonneoplastic lesions that arise in the setting of primary or secondary hyperparathyroidism. Parathyroid adenomas or hyperplasia constitute the major Brown tumor source in primary hyperparathyroidism while chronic renal failure is the leading cause in secondary hyperparathyroidism. Most of the patients with the diagnosis of primary hyperparathyroidism present with kidney stones or isolated hypercalcemia. However, nearly one third of patients are asymptomatic and hypercalcemia is found incidentally. Skeletal involvement such as generalized osteopenia, bone resorption, bone cysts and Brown tumors are seen on the late phase of hyperparathyroidism. The symptoms include axial pain, radiculopathy, myelopathy and myeloradiculopathy according to their locations. Plasmocytoma, lymphoma, giant cell tumors and metastates should be ruled out in the differential diagnosis of Brown tumors. Treatment of Brown tumors involve both the management of hyperparathyroidism and neural decompression. The authors report a very rare spinal Brown tumor case, arisen as the initial manifestation of primary hyperparathyroidism that leads to acute paraparesis.

show abstract

“…[ 18 ] 1990 F/51 Primary T6 and T7 bodies Paraparesis Surgical resection and parathyroidectomy Barlow and Archer [ 19 ] 1993 F/31 Secondary Cervical Neck pain and cervicobrachial neuralgia Parathyroidectomy and Minerva jacket Sarda et al . [ 20 ] 1993 F/23 Primary T3-4 Paraparesis and radicular pain Surgical resection and parathyroidectomy Motateanu et al . [ 21 ] 1994 M/57 Primary L4-5 facet Lower limb radicular symptoms Surgical resection Mourelatus et al .…”

Section: Discussionmentioning

confidence: 99%

Osteoclastomas ('brown tumours') and spinal cord compression: a review

Arsalanizadeh

Westacott

2013

Clinical Kidney Journal

View full text Add to dashboard Cite

show abstract

Paraplegia due to osteitis fibrosa secondary to primary hyperparathyroidism: Report of a case

Cited by 19 publications

References 6 publications

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Brown Tumor of the Thoracic Spine: First Manifestation of Primary Hyperparathyroidism

Osteoclastomas ('brown tumours') and spinal cord compression: a review

Contact Info

Product

Resources

About