2005
DOI: 10.1373/clinchem.2005.048710
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Paraprotein Interference in an Assay of Conjugated Bilirubin

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Cited by 23 publications
(10 citation statements)
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“…Hemolysis, lipemia, and paraproteinemia can falsely increase direct bilirubin concentration. [27][28][29][30] In our study, the positive bias of vancomycin on direct bilirubin concentration was already observed at the lowest vancomycin concentration of 2.98 lg/mL, so this interference should be taken into account in result interpretation. The increase of the direct bilirubin fraction over the indirect one gives important information to differentiate hepatobiliary obstruction from intrahepatic jaundice causes (eg, acute hepatitis).…”
Section: Discussionmentioning
confidence: 73%
“…Hemolysis, lipemia, and paraproteinemia can falsely increase direct bilirubin concentration. [27][28][29][30] In our study, the positive bias of vancomycin on direct bilirubin concentration was already observed at the lowest vancomycin concentration of 2.98 lg/mL, so this interference should be taken into account in result interpretation. The increase of the direct bilirubin fraction over the indirect one gives important information to differentiate hepatobiliary obstruction from intrahepatic jaundice causes (eg, acute hepatitis).…”
Section: Discussionmentioning
confidence: 73%
“…As described in previous literature paraproteins are known to cause interference in the estimation of several biochemical parameters including total bilirubin, albumin, creatinine, phosphate, calcium and iron in human serum [2][3][4][5][6][7][8]. The falsely elevated serum bilirubin level is supposed to result from a white precipitate arising out of reaction of paraprotein with the solubilizing agent in total bilirubin reagent [2].…”
Section: Discussionmentioning
confidence: 99%
“…Paraproteins are a common cause of interference in routine chemistry methods [1,2], and the direct bilirubin (D-Bil) AU Beckman Coulter assay seems to be particularly sensitive to this interference [3][4][5][6]. This test is a two-cuvette (blank and color) endpoint assay based on the formation of azobilirubin [by reaction of conjugated (direct) bilirubin from the serum sample with a diazonium salt at low pH], which is then measured bichromatically at 570/660 nm.…”
Section: Introductionmentioning
confidence: 99%