Paraproteinemia-Associated Papular Neutrophilic Xanthoma of the Oral Commissure in a Patient With Myelodysplastic Syndrome

Somerset, Nathan M.; Wolfe, Christopher M.; Soni, Bhavik P.

doi:10.1097/dad.0b013e318288cd8d

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…1,2 Recently, neutrophilic xanthoma has been reported. 3,4,5 Lu et al reported the case of a patient with hypergammaglobulinemia and polychondritis complicated with normolipemic xanthomatosis and Sweet's syndrome. 3 Neutrophilic dermatosis is heterogeneous and includes Sweet's syndrome, Behcet's disease and rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Normolipemic xanthomatized Sweet’s syndrome: A variant of Sweet’s syndrome with myelodysplastic syndrome

Kamimura

Yanagisawa

Tsunemi

et al. 2021

The Journal of Dermatology

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We report a rare case of xanthomatized Sweet's syndrome with myelodysplastic syndrome (MDS) in a patient who presented with erythematous plaques on his chest that were elevated and became yellowish. A diagnosis of MDS with single lineage dysplasia was made during the development of the eruption. Bone marrow biopsy showed an increased number of megakaryoblasts. Histopathologically, there was neutrophil infiltration with leukocytoclasia and the infiltration of xanthomatous cells. Immunohistochemical analysis revealed that the xanthomatized cells were predominantly CD163 positive. We propose that our case of xanthomatized neutrophilic dermatosis is a rare clinicopathological variant of Sweet's syndrome associated with a hematologic disorder.

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Section: Discussionmentioning

confidence: 99%

Normolipemic xanthomatized Sweet’s syndrome: A variant of Sweet’s syndrome with myelodysplastic syndrome

Kamimura

Yanagisawa

Tsunemi

et al. 2021

The Journal of Dermatology

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Xanthomatized Neutrophilic Dermatosis in a Patient With Myelodysplastic Syndrome

Ferris

Fabbro

Gru³

et al. 2017

The American Journal of Dermatopathology

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We present an original case report of a 58-year-old man with a history of histiocytoid Sweet and myelodysplastic syndrome who presented with a new onset of tender plaques on his oral commissures. A biopsy revealed a dense dermal neutrophilic infiltrate, leukocytoclasis without frank vasculitis, and, most notably, the presence of many xanthomatized cells. Clinical presentation and histologic features were most consistent with an acute neutrophilic dermatosis, which we believe to be a xanthomized variant of Sweet syndrome. Recent cases have described patients with similar clinical features and neutrophilic dermatosis in the setting of a normolipemic xanthomatosis. These cases were ultimately diagnosed as neutrophilic xanthoma, suggesting a possible histologic overlap between neutrophilic xanthoma and Sweet syndrome. Given these findings, we propose xanthomatized Sweet syndrome as a new histologic variant.

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Paraproteinemia-Associated Papular Neutrophilic Xanthoma of the Oral Commissure in a Patient With Myelodysplastic Syndrome

Cited by 2 publications

References 7 publications

Normolipemic xanthomatized Sweet’s syndrome: A variant of Sweet’s syndrome with myelodysplastic syndrome

Normolipemic xanthomatized Sweet’s syndrome: A variant of Sweet’s syndrome with myelodysplastic syndrome

Xanthomatized Neutrophilic Dermatosis in a Patient With Myelodysplastic Syndrome

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