Paraproteinemia in patients with scleredema

Ohta, Akio; Uitto, Jouni; Oikarinen, Aarne; Palatsi, Riitta; Mitrane, Margaret; Bancila, Edita; Seibold, James R.; Kim, Hugh C.

doi:10.1016/s0190-9622(87)70009-7

Cited by 65 publications

(11 citation statements)

References 28 publications

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“…eine monoklonale IgG-oder IgA-Paraproteinämie zugrunde [12,18]. Besonders häufig tritt das Scleroedema adultorum zusammen mit Diabetes mellitus und Infektionen auf.…”

Section: Scleroedema Adultorum Buschke · Hyperparathyreoidismusunclassified

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Scleroedema adultorum bei sekundärem Hyperparathyreoidismus

2002

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Scleredema adultorum, or Buschke's scleredema, belongs to the group of mucinoses. It is characterised by thickened and indurated skin. Histopathology shows thickened dermis with an infiltration of mucin between swollen collagen bundles. There are reports about many associations with scleredema adultorum, e.g., with diabetes mellitus and multiple myeloma. One case is known with associated primary hyperparathyroidism. For the first time we report a case of scleredema adultorum and secondary hyperparathyroidism, in a 46-year-old patient. Both forms of hyperparathyroidism have increased levels of parathormone. Therefore, these increased levels could have an influence on collagen metabolism.

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“…eine monoklonale IgG-oder IgA-Paraproteinämie zugrunde [12,18]. Besonders häufig tritt das Scleroedema adultorum zusammen mit Diabetes mellitus und Infektionen auf.…”

Section: Scleroedema Adultorum Buschke · Hyperparathyreoidismusunclassified

“…Über das gemeinsame Auftreten vom Scleroedema adultorum Buschke mit Paraproteinämie und multiplen Myelomen [12,18], malignem Insulinom [13], rheumatoide Arthritis und Sjögren-Syndrom [17], primärer Hyperparathyreoidismus [2] und anaphylaktischer Purpura [20] wurde in der Literatur berichtet (Tabelle 1). Das häufig gleichzeitige Vor-…”

Section: Assoziierte Erkrankungenunclassified

Scleroedema adultorum bei sekundärem Hyperparathyreoidismus

2002

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“…Several cases with an association between scleredema of Buschke (SB) and paraproteinaemia have been reported. 1–7 It is noted that the skin disease most often responds to the treatment of the malignant gammopathy 3,6 , 7 . Recently we suggested that the noninvasive measurements of skin mechanical properties are useful for objective and quantitative assessment of skin induration in systemic sclerosis 8 and SB.…”

Section: Reportmentioning

confidence: 99%

“…Thickening and induration of the skin in SB are due to the increased biosynthetic activity of skin fibroblasts and deposition of collagen and glycosaminoglycans in the dermis. 10 Experiments in vitro have shown that serum taken from SB patients with 2,3 or without MM 10 is able to stimulate the production of procollagen and/or glycosaminoglycans in dermal fibroblasts cultures. However, it is not certain that the stimulating substance in the patient serum is related to the monoclonal immunoglobulin.…”

Section: Reportmentioning

confidence: 99%

Biomechanical measurement of skin distensibility in scleredema of Buschke associated with multiple myeloma

Grudeva-Popova

Dobrev

2000

Clinical and Experimental Dermatology

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We report a case of scleredema of Buschke associated with IgG kappa monoclonal hypergammaglobulinaemia. After myeloma polychemotherapy an improvement in skin involvement was observed and confirmed by means of noninvasive skin elasticity measurements. This suggests a relationship between the two diseases. The bioengineering method used can be useful for early detection and monitoring the skin involvement in patients with this disease association.

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“…Am häufigsten werden IgG oder IgA Paraproteine gefunden [14,16,18]. Oft findet eine Progression Richtung Plasmozytom statt [11,15,18,24,25,26,28,29]. Meist tritt die monoklonale Gammopathie erst Jahre nach den Hautveränderungen in Erscheinung.…”

Section: Besprechungunclassified

Scleroedema adultorum Buschke

Ulmer

Schaumburg-Lever

Bauer³

et al. 1998

Der Hautarzt

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Scleredema adultorum of Buschke is a rare disorder of unknown aetiology. It is characterized by diffuse, non-pitting swelling and induration of the skin. Skin biopsies reveal marked thickening of the dermis due to collagenous replacement of the subcutis and deposition of hyaluronic acid between the collagen fibers. The disease classically only affects the skin. In 24 cases an associated monoclonal gammopathy has been detected. A 75-year-old patient had a 19-year history of scleredema adultorum. In addition to a monoclonal gammopathy the patient suffered from involvement of the tongue, pharynx and upper esophagus. Furthermore a polyneuropathy, ocular involvement with restricted eye movements and a sicca syndrome were present. The simultaneous occurrence of cutaneous scleredema with any one of the above mentioned symptoms has been reported before. The wide variety of extracutaneous manifestations of scleredema as found in our patient is amazing and has not been previously described.

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Paraproteinemia in patients with scleredema

Cited by 65 publications

References 28 publications

Scleroedema adultorum bei sekundärem Hyperparathyreoidismus

Scleroedema adultorum bei sekundärem Hyperparathyreoidismus

Biomechanical measurement of skin distensibility in scleredema of Buschke associated with multiple myeloma

Scleroedema adultorum Buschke

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