Paraquat exposure as an etiological factor of Parkinson's disease

Dinis-Oliveira, Ricardo Jorge; Remião, Fernando; Carmo, Helena; Duarte, José Alberto; Navarro, Amparo Sánchez; Bastos, Maria de Lourdes; Carvalho, Félix

doi:10.1016/j.neuro.2006.05.012

Cited by 280 publications

(161 citation statements)

References 126 publications

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“…PQ has been well attributed to damage in mitochondria and mitochondrial complex I inhibition by producing superoxide anions [11]. Drosophila is widely used as a model to understand mechanisms involved in neurodegenerative disorders (NDD) [12] and environmental toxin-induced parkinsonism [13]. Drosophila is also used as a convenient model to screen therapeutic agents for their effects on the cellular, biochemical and genetic systems [14].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Decalepis hamiltonii in Paraquat-Induced Neurotoxicity in Drosophila melanogaster: Biochemical and Behavioral Evidences

et al. 2013

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In this paper, we have demonstrated for the first time, the antioxidant and neuroprotective effects of Decalepis hamiltonii (Dh) root extract against paraquat (PQ)-induced oxidative stress and neurotoxicity in Drosophila melanogaster. Exposure of adult D. melanogaster (Oregon K) to PQ induced oxidative stress as evidenced by glutathione depletion, lipid peroxidation and enhanced activities of antioxidant enzymes such as catalase, superoxide dismutase as well as elevated levels of acetylcholine esterase. Pretreatment of flies by feeding with Dh extract (0.1, 0.5 %) for 14 days boosted the activities of antioxidant enzymes and prevented the PQ-induced oxidative stress. Dietary feeding of Dh extract prior to PQ exposure showed a lower incidence of mortality and enhanced motor activities of flies in a negative geotaxis assay; both suggesting the neuroprotective potential of Dh. Based on the results, we contemplate that the roots of Dh might prevent and ameliorate the human diseases caused by oxidative stress. The neuroprotective action of Dh can be attributed to the antioxidant constituents while the precise mechanism of its action needs further investigations.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Decalepis hamiltonii in Paraquat-Induced Neurotoxicity in Drosophila melanogaster: Biochemical and Behavioral Evidences

et al. 2013

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“…Silencing DJ-1 in neuroblastoma cells induced apoptotic cell death, and the treatment with PQ increased apoptosis (R. Gonzalez-Polo et al, 2009). The cytotoxic actions of PQ have been shown to involve oxidative stress by producing superoxide anions through the mitochondrial electron transport chain (Dinis-Oliveira et al, 2006;McCormack et al, 2002). PQ has been shown to be reduced by mitochondrial complex I and, thus, impair the respiration complex that led to the generation of ROS to induce selective neurodegeneration in dopaminergic neurons in the substantia nigra pars compacta (Fei et al, 2008) and apoptosis by activating different intracellular pathways.…”

Section: Fig 2 Redox Cycle Of Paraquatmentioning

confidence: 99%

Paraquat, Between Apoptosis and Autophagy

González‐Polo¹,

Pedro²,

Gómez‐Sánchez³

et al. 2012

Toxicity and Drug Testing

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“…Por esta razão, é possível que o tecido conjuntivo possua também um papel importante na tolerância induzida pelo exercício, Uma semana após a oitava sessão de treino, os animais foram anestesiados com injeção intraperitonial de ketamina e xilazina e eutanizados por exsanguinação, procedendo-se de seguida à colheita amostral dos músculos quadríceps (reto femoral; vasto lateral; vasto medial). (6,7,8) . Analisaram-se no total 100 fotos, 50 por cada grupo e 10 por músculo.…”

Section: Introductionunclassified

O treino com exercícios de contração excêntrica induz a longo prazo fibrose muscular esquelética

Pacheco¹,

Rocha²,

Teixeira³

et al. 2016

RPCD

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Músculo Quadriceps. RESUMOO exercício excêntrico (ExEx), inabitual ou extenuante, é um indutor de dano muscular esquelético. Contudo, quando repetido no tempo, de forma habitual, motiva tolerância muscular a essa agressão. Apesar das adaptações crónicas das fibras musculares poderem explicar alguma desta tolerância, não é de excluir a possível contribuição do aumento do tecido conjuntivo muscular para essa proteção induzida pelo treino. Assim, o objetivo deste trabalho foi o de avaliar as alterações no conteúdo de colagénio do músculo quadríceps sujeito a treino com ExEx. Ratos Wistar machos foram divididos em dois grupos (n = 5 por grupo): sedentário controlo (SED) e treinado (TR). Os animais TR praticaram corrida em tapete rolante (-25º; 30m/ minuto; 60 min) 1x/ semana, durante 8 semanas. A atividade sanguínea da creatina quinase (CK) foi avaliada ao longo do protocolo e, após sacrifício, recolheu-se o músculo quadríceps para análise histológica. Os resultados da CK demostraram o efeito protetor do treino ao exercício (p = .002). Nos músculos esqueléticos, observou-se um aumento da área de secção transversal (p < .000) das fibras musculares, simultaneamente com um aumento do conteúdo total de colagénio e da espessura do endomísio (p < .000). É possível concluir-se que, paralelamente ao efeito de tolerância, o treino ExEx promoveu um acentuado aumento do conteúdo muscular esquelético de colagénio e um incremento moderado da área de secção transversal das fibras musculares. there was a moderate increase in muscle fibbers cross-sectional area (p < 0.000), simultaneously with a huge increase in the total collagen content and endomysium thickness (p < .000). It can be concluded that, in addition to the tolerance effect, EcEx training induced a remarkable increase in skeletal muscle collagen content, in parallel with a moderate increase of muscle fibbers' cross-sectional area.

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Paraquat exposure as an etiological factor of Parkinson's disease

Cited by 280 publications

References 126 publications

Neuroprotective Effect of Decalepis hamiltonii in Paraquat-Induced Neurotoxicity in Drosophila melanogaster: Biochemical and Behavioral Evidences

Neuroprotective Effect of Decalepis hamiltonii in Paraquat-Induced Neurotoxicity in Drosophila melanogaster: Biochemical and Behavioral Evidences

Paraquat, Between Apoptosis and Autophagy

O treino com exercícios de contração excêntrica induz a longo prazo fibrose muscular esquelética

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