Paraquat induces different programmed cell death patterns in Microcystis aeruginosa and Chlorella luteoviridis

Bai, Fang; Jia, Yunlu; Li, Jie; Wu, Zhongxing; Li, Lin; Song, Lirong

doi:10.1016/j.ecoenv.2022.114429

Cited by 10 publications

(2 citation statements)

References 58 publications

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“…Another study similarly found that polybrominated diphenyl ethers in Thalassiosira pseudonana caused alterations in cellular ROS levels that were connected with PCD indicators and the dead cell ratio [106]. The increase in caspaselike activity occurred simultaneously with an increase in ROS in M. aeruginosa [107]. Thus, the ROS served as a signaling molecule that caused the test species' caspase-3(-like) activity to increase (Figure 5).…”

Section: Uv-mediated Cell Death/apoptosismentioning

confidence: 90%

Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress

Singh

Jha

Rana

et al. 2023

IJMS

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Ultraviolet radiation (UVR) tends to damage key cellular machinery. Cells may adapt by developing several defence mechanisms as a response to such damage; otherwise, their destiny is cell death. Since cyanobacteria are primary biotic components and also important biomass producers, any drastic effects caused by UVR may imbalance the entire ecosystem. Cyanobacteria are exposed to UVR in their natural habitats. This exposure can cause oxidative stress which affects cellular morphology and vital processes such as cell growth and differentiation, pigmentation, photosynthesis, nitrogen metabolism, and enzyme activity, as well as alterations in the native structure of biomolecules such as proteins and DNA. The high resilience and several mitigation strategies adopted by a cyanobacterial community in the face of UV stress are attributed to the activation of several photo/dark repair mechanisms, avoidance, scavenging, screening, antioxidant systems, and the biosynthesis of UV photoprotectants, such as mycosporine-like amino acids (MAAs), scytonemin (Scy), carotenoids, and polyamines. This knowledge can be used to develop new strategies for protecting other organisms from the harmful effects of UVR. The review critically reports the latest updates on various resilience and defence mechanisms employed by cyanobacteria to withstand UV-stressed environments. In addition, recent developments in the field of the molecular biology of UV-absorbing compounds such as mycosporine-like amino acids and scytonemin and the possible role of programmed cell death, signal perception, and transduction under UVR stress are discussed.

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Section: Uv-mediated Cell Death/apoptosismentioning

confidence: 90%

Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress

Singh

Jha

Rana

et al. 2023

IJMS

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“…Paraquat (PQ), a quaternary nitrogen herbicide, is highly toxic to human beings and animals. − Accidental or spontaneous ingestion of PQ would cause an acute poisoning reaction that damages the major organs, resulting in rapid multiorgan failure with a mortality rate of 50–80%. − PQ induces its toxic effects mainly through generation of abundant reactive oxygen species (ROS), including H 2 O 2 , • O 2 – , and HO • by redox cycling. − Abundant ROS will destroy mitochondria, resulting in the activity decrease of a variety of antioxidant enzymes and then causing acute alveolitis, inflammatory cell infiltration, rapid pulmonary interstitial fibrosis, and even death. − In clinical practice, several strategies have been developed to detoxify PQ poisoning. Activated carbon and montmorillonite powder are ordinarily used via gastric administration, and 20% mannitol is used as a cathartic for accelerating PQ excretion to prevent its further absorption. − Numerous antioxidants have also been developed to treat PQ poisoning, including vitamin E, vitamin C, and glutathione. − Additionally, hemoperfusion, immunosuppression, and supportive care measures are taken to detoxify PQ poisoning in clinics. ,− Unfortunately, the current treatments are moderately effective and nonspecific, resulting in poor therapeutic outcomes. ,,− …”

Section: Introductionmentioning

confidence: 99%

Host–Guest Formulation of Carboxylatopillar[6]arene with Ergothioneine as a New Antidote for Combinational Detoxification of Paraquat

Chen¹,

Chen

Wang³

et al. 2023

ACS Appl. Mater. Interfaces

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Paraquat (PQ) is exceptionally toxic to the human body. PQ ingestion can cause severe organ damage with a mortality rate of 50–80%, resulting from the absence of effective antidotes and detoxification solutions. Herein, a host–guest formulation is proposed, in which ergothioneine (EGT), an antioxidant drug, was encapsulated by carboxylatopillar[6]arene (CP6A) to achieve a combinational therapy for PQ poisoning. Nuclear magnetic resonance (NMR) and fluorescence titration were employed to confirm the complexation between CP6A and EGT as well as PQ with robust affinities. In vitro studies proved that EGT/CP6A significantly reduced PQ toxicity. Treatment with EGT/CP6A could effectively relieve organ damage caused by PQ ingestion and enhance the normalization of hematological and biochemical parameters. The host–guest formulation EGT/CP6A also improved the survival ratio in PQ-poisoned mice. These favorable outcomes originated from synergistic effects that PQ triggered the release of EGT to combat peroxidation damage and excess PQ was engulfed within the cavity of CP6A.

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The hidden world of cyanobacterial cell death: classification, regulatory mechanisms, and ecological significance

Bhattacharjee,

Parida,

Aguilera

et al. 2024

Cyanobacteria

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Paraquat induces different programmed cell death patterns in Microcystis aeruginosa and Chlorella luteoviridis

Cited by 10 publications

References 58 publications

Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress

Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress

Host–Guest Formulation of Carboxylatopillar[6]arene with Ergothioneine as a New Antidote for Combinational Detoxification of Paraquat

The hidden world of cyanobacterial cell death: classification, regulatory mechanisms, and ecological significance

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