2015
DOI: 10.1016/j.chom.2015.06.003
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Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans

Abstract: SUMMARY Apicomplexans invade a variety of metazoan host cells through mechanisms involving host cell receptor engagement and secretion of parasite factors to facilitate cellular attachment. We find that the parasite homolog of calcineurin, a calcium-regulated phosphatase complex central to signal transduction in eukaryotes, also contributes to host cell invasion by the malaria parasite Plasmodium falciparum and related Toxoplasma gondii. Using reverse genetic and chemical-genetic approaches, we determine that … Show more

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Cited by 91 publications
(140 citation statements)
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“…Depleting CnB in tightly synchronized blood stage P. falciparum parasites had no effect on intraerythrocytic development but had a very strong effect on erythrocyte invasion; CnA depletion had a similar impact (Paul et al, 2015). Critically, depletion of CnB had no impact on the exocytosis of invasion ligands from either micronemes or rhoptry organelles, even when CnB depletion was combined with drug inhibition to potentiate the effect in a chemical genetic approach.…”
Section: Calcineurin Regulates Host Cell Attachment In Apicomplexan Pmentioning
confidence: 96%
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“…Depleting CnB in tightly synchronized blood stage P. falciparum parasites had no effect on intraerythrocytic development but had a very strong effect on erythrocyte invasion; CnA depletion had a similar impact (Paul et al, 2015). Critically, depletion of CnB had no impact on the exocytosis of invasion ligands from either micronemes or rhoptry organelles, even when CnB depletion was combined with drug inhibition to potentiate the effect in a chemical genetic approach.…”
Section: Calcineurin Regulates Host Cell Attachment In Apicomplexan Pmentioning
confidence: 96%
“…By contrast, the role of the protein phosphatases that remove these moieties has remained largely unexplored. Two papers in this issue address this gap by performing detailed functional studies of the calcium-regulated protein phosphatase calcineurin (Paul et al, 2015;Philip and Waters, 2015).…”
Section: Calcium-a Critical Second Messenger Regulating Parasite Invamentioning
confidence: 98%
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“…The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate 28 between intracellular replicating forms and actively motile extracellular forms that move of the glideosome and the release of adhesins from the micronemes 7,12,13 [14][15][16][17][18][19] .…”
mentioning
confidence: 99%