Parasite‐specific immune response in adult <i>Drosophila melanogaster:</i> a genomic study

Roxström-Lindquist, Katarina; Terenius, Olle; Faye, Ingrid

doi:10.1038/sj.embor.7400073

Cited by 116 publications

(114 citation statements)

References 24 publications

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“…A second point of importance will be the identification of antiviral molecules in Drosophila. Finally, it seems appropriate to study the immune response after natural viral infection because the route of entry may influence the host response: Only few genes were induced in microarray studies after oral ingestion of DCV (266), in contrast to the robust response observed after DCV injection (91).…”

Section: Drosophila C Virus (Dcv)mentioning

confidence: 99%

The Host Defense of Drosophila melanogaster

Lemaître

Hoffmann

2007

Annu. Rev. Immunol.

2,954

3,089

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To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physical barriers together with local and systemic immune responses. First, epithelia, such as those beneath the cuticle, in the alimentary tract, and in tracheae, act both as a physical barrier and local defense against pathogens by producing antimicrobial peptides and reactive oxygen species. Second, specialized hemocytes participate in phagocytosis and encapsulation of foreign intruders in the hemolymph. Finally, the fat body, a functional equivalent of the mammalian liver, produces humoral response molecules including antimicrobial peptides.Here we review our current knowledge of the molecular mechanisms underlying Drosophila defense reactions together with strategies evolved by pathogens to evade them.

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Section: Drosophila C Virus (Dcv)mentioning

confidence: 99%

The Host Defense of Drosophila melanogaster

Lemaître

Hoffmann

2007

Annu. Rev. Immunol.

2,954

3,089

View full text Add to dashboard Cite

show abstract

“…pes is required for the uptake of Mycobacterium smegmatis and Listeria monocytogenes by macrophages (Philips et al, 2005), and its expression in midgut and salivary glands has been previously described (Cao et al, 2007;Li et al, 2009). CG2736 appears to be part of the D. melanogaster lipid droplet subproteome (Beller et al, 2006), being induced by infection with Octosporea muscaedomesticae (Roxstrom-Lindquist et al, 2004) and upregulated in fly stocks resistant to infection with Pseudomonas aeruginosa, as well as CG10345 (Ye et al, 2009). In the case of Snmp, it is required for pheromone sensitivity in Drosophila and it is implicated in the reception of 11-cis-vaccenyl acetate (cVA), which mediates a variety of behaviours including aggregation, mate recognition and sexual behaviour.…”

Section: Fig 5 Temporal Regulation Of the Sr-bis In Non Esteroidogementioning

confidence: 99%

Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster

Herboso¹,

Talamillo²,

Pérez³

et al. 2011

Int. J. Dev. Biol.

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In mammals, cholesterol is transformed into steroid hormones in the adrenal gland, the ovaries or the testes. The Scavenger Receptors Class B Type I (SR-BI) are membrane proteins that belong to the CD36 family and participate in the selective uptake of high density lipoprotein cholesteryl ester in the mammalian steroidogenic tissues. Fourteen members of the CD36 family have been identified in Diptera, although their expression patterns remain uncharacterized. Using in situ hybridization we have characterized the expression patterns of the fourteen SR-BIs in Drosophila melanogaster. We analyzed three different developmental larval stages prior to and during the peak of the insect steroid hormone ecdysone, which triggers the larval to pupal transition. We focused on the steroidogenic tissues, such as the prothoracic gland, the ovaries and the testes, and extended our analysis to non-steroidogenic tissues, such as the fat body, salivary glands, the gut, the gastric caeca or the central nervous system. Our results show highly regulated expression patterns, with three genes crq, pes and Snmp being upregulated in steroidogenic tissues at the onset of pupariation when steroidogenesis is crucial. This study underlines the importance of the transport of cholesterol and steroids in the process of ecdysone synthesis.

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“…Further, only male physiology has been used in the genomics-based approaches to immune response genes. [12][13][14] In this work, we present a baseline comparison that begins to address the issues and opportunities afforded by studying both sexes. Our experiments assess post-infection survival against the commonly studied microorganisms Beauveria bassiana and E. coli, and the results show a dichotomy between the sexes.…”

Section: Introductionmentioning

confidence: 99%