Parasitémie asymptomatique chez les enfants de moins de 5 ans, enfants en âge scolaire et prise en charge des épisodes fébriles dans les ménages de Lubumbashi, République Démocratique du Congo

Mukomena, Sompwe Eric; Philipe, Cilundika Mulenga; Désiré, Mashinda Kulimba; Pascal, Lutumba Tshindele; Ali, Mapatano Mala; Oscar, Luboya Numbi

doi:10.11604/pamj.2016.24.94.9350

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…This is consistent with the results of a study carried out in Ota, South west Nigeria 37 and contradicts the findings of another study conducted in Nigeria, in Aba town. 32 Furthermore, the prevalence of asymptomatic carriage in the present study (22.63% in the study population and 44.20% among infected children) was higher than previously described across the country 31,38 and on the continent, particularly in Lubumbashi in the Democratic Republic of the Congo (16%) 39 and Aba in Nigeria (33.1%), 32 although higher prevalences (57.3% and 45. 9%) were reported in Ota in southwestern Nigeria 37 and in Dienga in southeastern…”

Section: Discussioncontrasting

confidence: 47%

Differential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon

Ontoua

Kouna

Oyegue-Liabagui

et al. 2021

IDR

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Plasmodium falciparum malaria remains a major public health challenge in sub-Saharan Africa. Plasmodium falciparum drug resistance mediated by polymorphisms in the Pfmdr1 gene contributes to the persistence of the disease on the African continent. This study investigated P. falciparum infection features and differences in the Pfmdr1 genotypes between symptomatic and asymptomatic malaria cases in a rural area in east-central Gabon.Patients and Methods: A total of 875 children aged from 5 to 185 months were screened for P falciparum infection using Optima-IT ® rapid diagnostic tests and standard microscopy. Pfmdr1 polymorphisms at codons 86, 184 and 1246 were investigated using PCR-RFLP. Results: Among the 448 P. falciparum-infected children, 57.08% (n=250) were symptomatic and 42.92% (n=198) were asymptomatic (p < 0.0001). In a sub-set of 79 isolates, the Pfmdr1 wild-type N86 was more prevalent in symptomatic (100%) than in asymptomatic infections (70.7%) (p=0.007). The mutant 86Y and mixed 86N/Y genotypes were observed only in asymptomatic infections. The Y184 and 184F genotype prevalences (39.1% vs 19.4% and 60.9% vs 80.6%, respectively) were not significantly different between the two groups (p=0.097). The prevalence of the wild-type D1246 differed significantly between symptomatic (10.3%) and asymptomatic (100%) (p < 0.0001). The NFD and YFD haplotypes were more prevalent in asymptomatic than in symptomatic infections [(61.9% vs 31%; p=0.005) and (16.7% vs 0.0%; p=0.01)], whereas the NYD and YYD haplotypes were not significantly different between the two groups [(21.4% vs 14.3%, p=0.39) and (0.0% vs 7.1%, p=0.24)]. Conclusion: Our results confirm a high transmission of P. falciparum infection in rural Gabon, with a high prevalence of asymptomatic carriage. The higher prevalences of wildtype N86 in symptomatic infections and of D1246 in asymptomatic infections suggest a pathogenicity associated with polymorphisms in Pfmdr1. These results highlight the need to monitor the efficacy of artemisinin-based combination therapies in Gabon.

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Section: Discussioncontrasting

confidence: 47%

Differential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon

Ontoua

Kouna

Oyegue-Liabagui

et al. 2021

IDR

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“…Some studies have attributed caregivers’ educational level to children's risk of malaria infections, with children whose caregivers had no education at all having higher risk than those with higher education [ 14 ]. It could be assumed that caregivers with higher formal education are more likely to have greater awareness and knowledge of malaria infection, as found in the study by Mukomena et al in Dembele kebele in south-eastern Ethiopia [ 33 ]. Our study, however, found that caregivers’ educational level influenced malaria among their wards only at the bivariate level.…”

Section: Discussionmentioning

confidence: 99%

Burden of malaria in children under five and caregivers’ health-seeking behaviour for malaria-related symptoms in artisanal mining communities in Ghana

et al. 2021

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Background Artisanal mining creates enabling breeding ground for the vector of malaria parasites. There is paucity of data on the effects of artisanal mining on malaria. This study assessed burden of malaria and caregivers’ health-seeking behaviour for children under five in artisanal mining communities in East Akim District in Ghana. Methods A cross-sectional study involving caregivers and their children under five was conducted in three artisanal mining communities in the East Akim District in Ghana. Caregivers were interviewed using a structured questionnaire. Finger prick blood samples were collected and analysed for haemoglobin concentration using a rapid diagnostic test, and thick and thin blood smears were analysed to confirm the presence of malaria parasites. Results Of the 372 children under 5 years included in the study, 197 (53.1%) were male, with a mean age (± SD) of 23.0 ± 12.7 months. The proportion of children with malaria (Plasmodium falciparum and P. malariae) was 98.1% and 1.9%, respectively, whilst the proportion with anaemia (Hb < 11.0 g/dl) was 39.5% (n = 147). Almost all caregivers were female (98.9%), and 28.6% (n = 106) did not have access to any malaria control information. Caregivers associated malaria infection with mosquito bites (68.3%, n = 254) and poor sanitation (21.2%, n = 79). Malaria in children under five was significantly associated with anaemia (OR 11.07, 95% CI 6.59–18.68, n = 111/160, 69.4%; P < 0.0001), residing close to stagnant water (≤ 25 m) from an artisanal mining site (AOR 2.91, 95% CI 1.47–5.76, P = 0.002) and caregiver age younger than 30 years (OR 0.44, 95% CI 0.208–0.917, n = 162, 43.55%, P = 0.001). Conclusions There is a high burden of malaria and anaemia among children under five in artisanal mining communities of the East Akim District, and far higher than in non-artisanal mining sites. Interventions are needed to effectively regulate mining activities in these communities, and strengthen malaria control and health education campaigns to curtail the high malaria burden and improve health-seeking behaviour. Graphical abstract

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“…Several patients interviewed (3661 or 73.6%) also use medicinal plants, 18 of which have been mentioned. These plants belong to 13 families dominated by Asteraceae (23%).…”

Section: Medicinal Plants Used In Self-medication Against Malaria In Lubumbashimentioning

confidence: 99%

“…From these plants flow 20 recipes which mainly use (80%) leaves as a decoction (75%) and which are administered orally (100%). Carica papaya (18), Cymbopogon. citratus (15) and Eucalyptus abdita (15) are the three most cited plants (Table 5) and Cissus aralioides is the only one whose anti-malarial use has not been reported in the literature.…”

Section: Medicinal Plants Used In Self-medication Against Malaria In Lubumbashimentioning

confidence: 99%

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Self-medication with antimalarials drugs in Lubumbashi city (DR Congo)

Valentin

Salvius

Philippe

et al. 2020

GSC Biol. and Pharm. Sci.

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Self-medication for malaria is very common in Sub-Saharan Africa where this parasitosis is endemic. In order to determine the extent, characteristics and factors associated with this practice in medical area in the city of Lubumbashi, a cross-sectional descriptive study was carried out by direct interview from January 2018 to June 2018, in the internal medicine departments of 10 General Referral Hospital (GRH) . Five thousand one hundred and thirtyfour patients were consulted among them, 96.6% (average age 38.7 ± 8 years; average income: 100 ± 12 USD; gender male/ female ratio: 0.86) practice self-medication with antimalarials. They used it for the first time at an average age of 13-17 years. Quinine (36.4%) and Carica papaya (0.4%) are the most used remedies in conventional and non-conventional medicine, respectively. Several risks are incurred during this practice when the most cited are worsening side effects (53%), incomplete treatment (37%) and appearance to health sciences (37%). Age (17-35 and > 65 years old), low income (50-150 USD), membership in a health sector and the claim to know antimalarial drugs, predispose patients to self-medication. There is an urgent need to regulate this practice to avoid its harmful consequences.

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Parasitémie asymptomatique chez les enfants de moins de 5 ans, enfants en âge scolaire et prise en charge des épisodes fébriles dans les ménages de Lubumbashi, République Démocratique du Congo

Cited by 6 publications

References 34 publications

Differential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon

Differential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon

Burden of malaria in children under five and caregivers’ health-seeking behaviour for malaria-related symptoms in artisanal mining communities in Ghana

Self-medication with antimalarials drugs in Lubumbashi city (DR Congo)

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