Parasites et cancer : existe-t-il un lien ?

Cheeseman, Kevin; Certad, Gabriela; Weitzman, Jonathan B

doi:10.1051/medsci/20163210020

Cited by 15 publications

(15 citation statements)

References 45 publications

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“…Although, while using an immunosuppressed mouse model, chronic C. parvum infection has been reported to cause neoplastic changes in the small intestine, suggesting a potential role as a carcinogen (Benamrouz et al, 2012a,b), the contribution of Cryptosporidium spp. to cancer etiology has been largely unexplored (Cheeseman et al, 2016). Taking into account the fact that among 145 examined patients in our study only one was infected with C. meleagridis , we consider this infection as opportunistic.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the occurrence of this subtype as well as the other C. meleagridis subtypes (IIIb, IIIc, IIIe, IIIf, IIIh and IIIi) in humans, indicates that they are susceptible to almost all subtypes of C. meleagridis (Abal-Fabeiro et al, 2013; Wang et al, 2013). Future studies should examine characteristics of carcinoma tissue that could increase susceptibility to Cryptosporidium infection, including altered mucin expression and loss of epithelial cell integrity (Nath and Mukherjee, 2014; Cheeseman et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient

Kopacz

Kváč

Karpiński

et al. 2019

Front. Cell. Infect. Microbiol.

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Objectives: The potential linkage between Cryptosporidium spp. infection and colorectal human cancer was suggested by limited reports showing higher prevalence of C. parvum and C. hominis in patients with colon cancer. Here we conducted research concerning presence of Cryptosporidium spp. in malignant tissue collected from patients with colorectal cancer. Methods: Cancerous colon tissue samples collected from 145 non-HIV infected patients with colorectal cancer were screened for Cryptosporidium spp. by immunofluorescence antibody test and genus-specific nested polymerase chain reaction followed by sequencing. Results: Screened pathogen was found in cancerous tissue originating from immunocompetent man with colon adenocarcinoma. Genotyping revealed presence of Cryptosporidium meleagridis . The presence of Cryptosporidium life cycle stages (oocysts and endogenous stages) in colon carcinoma tissue was confirmed by genus-specific FITC-labeling. Conclusions: Herein, we report on a C. meleagridis infection of a colon adenocarcinoma in an immunocompetent patient. This is the first report of C. meleagridis infection in the human colon and first evidence of active development of this species in cancer tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient

Kopacz

Kváč

Karpiński

et al. 2019

Front. Cell. Infect. Microbiol.

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“…In fact, the potential role of Cryptosporidium in the development of neoplasia would not be surprising, considering that epidemiological and clinical reports indicate that eukaryotic protozoan, such as intracellular apicomplexan that cause diseases of medical or economic importance, can be linked to various cancers, for instance: Theileria induce host cell transformation while Plasmodium was linked epidemiologically to the "African lymphoma belt" over fifty years ago [ 16 ]. These intracellular eukaryotic parasites hijack cellular pathways to manipulate the host cell epigenome, cellular machinery, signaling pathways and epigenetic programs and marks, such as methylation and acetylation, for their own benefit [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients

et al. 2017

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BackgroundThe association between Cryptosporidium and human colon cancer has been reported in different populations. However, this association has not been well studied. In order to add new strong arguments for a probable link between cryptosporidiosis and colon human cancer, the aim of this study was to determine prevalence and to identify species of Cryptosporidium among Lebanese patients.Methodology and principal findingsOverall, 218 digestive biopsies were collected in Tripoli, Lebanon, from three groups of patients: (i) patients with recently diagnosed colon intraepithelial neoplasia/adenocarcinoma before any treatment (n = 72); (ii) patients with recently diagnosed stomach intraepithelial neoplasia/adenocarcinoma before any treatment (n = 21); and (iii) patients without digestive intraepithelial neoplasia/adenocarcinoma but with persistent digestive symptoms (n = 125). DNA extraction was performed from paraffin-embedded tissue. The presence of the parasite in tissues was confirmed by PCR, microscopic observation and immunofluorescence analysis. We identified a high rate (21%) of Cryptosporidium presence in biopsies from Lebanese patients with recently diagnosed colonic neoplasia/adenocarcinoma before any treatment. This prevalence was significantly higher compared to 7% of Cryptosporidium prevalence among patients without colon neoplasia but with persistent gastrointestinal symptoms (OR: 4, CI: 1.65–9.6, P = 0.001). When the comparison was done against normal biopsies, the risk of infection increased 11-fold in the group of patients with colon adenocarcinoma (OR: 11.315, CI: 1.44–89.02, P = 0.003).ConclusionsThis is the first study performed in Lebanon reporting the prevalence of Cryptosporidium among patients with digestive cancer. These results show that Cryptosporidium is strongly associated with human colon cancer being maybe a potential etiological agent of this disease.

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“…Nowadays it has been proven that one of the most important causes of cancer is microbial pathogens such as Helicobacter pylori, Human papillomavirus, Hepatitis B and C viruses, Epstein-Barr virus, human immunodeficiency virus (HIV), and herpesvirus (6). However, other pathogens such as parasites can also be a cause of cancer.…”

Section: Introductionmentioning

confidence: 99%

Possible Association and Risk Factors of Blastocystis Infection and Colorectal Cancers in Western Iran

Mahmoudvand

Sepahvand

Badparva

et al. 2021

Arch Clin Infect Dis

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Background: Recently, infection has been considered one of the most important causes of cancers because a large number of cases of cancer with infectious origin was reported. Objectives: The present investigation aimed to evaluate the prevalence and risk factors of Blastocystis hominis infection in patients with colorectal cancer in comparison to healthy individuals. Methods: The present descriptive case-control study was performed on 67 healthy individuals and 67 patients with colorectal cancers attending the general hospitals of Lorestan Province, Western Iran from October 2017 to August 2018. Colorectal cancers were diagnosed by an experienced gastroenterologist. A fresh stool specimen was collected from each subject in a sterile labeled container. The collected specimens were tested microscopically using saline and iodine wet preparations, then stained with trichrome stain according to the manufacturer’s instruction to find the cases of B. hominis forms. The DNA of the samples was extracted and specific primer-polymerase chain reaction (PCR) was performed. Results: Among the colorectal cancer patients, B. hominis was found in 16 (23.9%) patients, whereas of 67 healthy participants, 6 (9%) cases were found, indicating a significant difference (P < 0.001) in the prevalence B. hominis among the participants in the case and control groups. By the multifactorial logistic regression models, agriculture activity (0.24; 95% CI: 0.075 - 0.809), as well as consumption of unwashed fruit and vegetables (0.136; 95% CI: 0.040 - 0.459), were significantly related to the prevalence of B. homonis infection. All 22 positive samples (16 patients and 6 (9%) healthy people) were also positive by PCR method, indicating the presence of B. hominis and accuracy of microscopic examination, extraction, and PCR reaction. Conclusions: The obtained findings revealed that B. hominis may strongly link with human colorectal cancers given novel information about the important role of B. hominis in the progress of colorectal cancer. Nevertheless, more investigations are required to obtain accurate information about this suggestion.

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Parasites et cancer : existe-t-il un lien ?

Cited by 15 publications

References 45 publications

The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient

The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient

High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients

Possible Association and Risk Factors of Blastocystis Infection and Colorectal Cancers in Western Iran

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