Parasitic Behavior of Self‐Replicating Molecules

Altay, Meniz; Altay, Yiğit; Otto, Sijbren

doi:10.1002/ange.201804706

Cited by 17 publications

(13 citation statements)

References 58 publications

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“…If we want to create molecular assemblies as complex and functional as the molecular assemblies in living systems, we should develop these assemblies out of equilibrium. Out of equilibrium, we can find complex behavior such as pattern formation, self-replication, 84 molecular evolution, 85,86 motion, 87,88 the exertion of forces, 89 and oscillations. 51 These synthetic The chemical reaction cycle driven by the hydrolysis of carbodiimides that forms dissipative crown ethers that can host cations.…”

Section: Discussionmentioning

confidence: 99%

The Design of Dissipative Molecular Assemblies Driven by Chemical Reaction Cycles

Rieß

Grötsch

Boekhoven

2020

Chem

208

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The field of supramolecular chemistry and molecular self-assembly has entered a new phase in which the use of chemical reactions to create out-of-equilibrium molecular assemblies is becoming more common. These dynamic assemblies have vastly different properties than their in-equilibrium counterparts, which include the ability to be controlled over space and time or the ability to selfreplicate. Such behaviors would set significant steps toward the synthesis of artificial life. However, a limiting factor toward the revolution of the field is the lack of clear definitions and design rules for such systems. In this review, we explain the core principles that help to design energy-dissipating chemical reaction cycles that can drive molecular assemblies. We discuss strategies for coupling these reaction cycles to building blocks for the materials. We conclude with an outlook for the field of dissipative self-assembly and its potential role as a material or model for life.

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Section: Discussionmentioning

confidence: 99%

The Design of Dissipative Molecular Assemblies Driven by Chemical Reaction Cycles

Rieß

Grötsch

Boekhoven

2020

Chem

208

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“…18, see Figure S64) are significantly shorter (0.5-5 μm) and only 2-5 nm wide. 47,50,54,55 CD spectroscopy ( Figure 2D) and thioflavin T (ThT) fluorescence assays ( Figure 2E) both indicated a (partial) β-sheet structure, similar to those of peptide fibers. 47 A comparison of the spectroscopic signatures of octamer 18 and mixed hexamer 1442 reveals an noticeable difference: whereas the intensity of the CD spectra are comparable, that of the ThT assay is markedly lower for 1442 ( Figure S63).…”

Section: Structure and Assembly Of The Mixed Hexamer 1 4 4mentioning

confidence: 84%

Controlling Supramolecular Plasticity through Stoichiometry

Komáromy¹,

Tiemersma‐Wegman²,

Kemmink³

et al. 2019

Preprint

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In this manuscript we describe how, by taking a systems approach, complex energy landscapes of supramolecular assemblies can be navigated using stoichiometry to control, with remarkable selectivity, which assembly gets populated. The perhaps counterintuitive finding is that it is not necessarily the assembly that, in a one-to-one comparison, is the most stable that wins the competition for common building blocks, even though the system is under thermodynamic control. Instead, an individually less stable assembly may completely dominate the system. This domination is possible when the building block stoichiometry in the system matches the stoichiometry of this specific assembly, allowing the system to maximize binding energy by making a large number of assemblies of moderate stability as opposed to a small number of more stable assemblies. <br>

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“…Yemek yerken birkaç asker sinekleri kovalamakla görevlendiriliyordu. 180 Türkler ve İngilizler göğüs göğüse boğuşuyorlardı. Kanlısırt savaşlarında Türk askeriyle İngiliz askerinin birbirlerini süngülemiş cesetleri vardı.…”

Section: Kara Savaşlarıunclassified

Organized Defense of Marash

Eyicil

2020

Kahramanmaraş Sütçü İmam Üniversitesi Sosyal Bilimler Dergisi

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idi. Bu arada savunmayı başarılı bir şekilde yürütmek için Maraş, 3. Kolordu Komutanı Selahattin Bey komutasına bağlandı. Savunma sırasında gelişmeler hakkında Atatürk'e düzenli bir şekilde ayrıntılı bilgiler verildi. 22 gün süren Maraş savunması düzenli ve disiplinli bir şekilde yürütüldü. Ayrıca gereği kadar silah ve mühimmat temin edildi. Gizlilik esası içinde yürütülen bu düzenli savunma, halkın kendisini savunması şeklinde gösterildi. İşgalcilerin tutumlarından memnun olmayan halkın da katkılarıyla Maraş savunması zaferle sonuçlandı.

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Parasitic Behavior of Self‐Replicating Molecules

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Cited by 17 publications

References 58 publications

The Design of Dissipative Molecular Assemblies Driven by Chemical Reaction Cycles

The Design of Dissipative Molecular Assemblies Driven by Chemical Reaction Cycles

Controlling Supramolecular Plasticity through Stoichiometry

Organized Defense of Marash

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