Parasitic Kidney Disease: Milestones in the Evolution of Our Knowledge

Barsoum, Rashad S.

doi:10.1053/j.ajkd.2012.09.025

Cited by 12 publications

(12 citation statements)

References 56 publications

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“…There are more than 342 parasites which affects human and at least 20 of them are associated with kidney related ailments. ( 64 ) Plasmodia, filariae, leishmania, and Schistosoma are common with diverse epidemiological distribution. The immunogenic and pathogenetic host response to these infections are common in many situations with widely associated spectrum of kidney diseases which extend from AKI to glomerulonephritis, amyloidosis, urologic disorders, and malignancy.…”

Section: Fungal Infectionsmentioning

confidence: 99%

Infection-Induced Kidney Diseases

Prasad

Patel

2018

Front. Med.

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Infection induced kidney diseases are of concern for clinicians because timely detection and treatment of infections may cure or limit the extent of injury inflicted by microorganisms causing the infections. Infections can cause kidney injury by either direct invasion, or indirectly by immune mediated mechanisms, which manifest as post-infectious glomerulonephritis, or infection-related glomerulonephritis. Clinical manifestations may be acute or chronic depending on the microorganisms, endemic/epidemic nature and source of infection. All microbials virus, bacteria, mycobacteria, fungus, and protozoa have been implicated in kidney diseases either causing direct kidney injuries or immune-mediated injuries. Infection control practices in large parts of world is limited by poverty, social behavior, high population density, deforestation, inadequate access to safe drinking water, and poor health care facilities. Although, antimicrobials and vaccinations have successfully eradicated and cured many infectious diseases; however injudicious antimicrobial use and emergence of resistant organisms complicated the disease severity like secondary renal amyloidosis with chronic persistent infection. Re-emergence of various infections has been a recent pattern in developed world leading to uncertain diagnostic challenges, and association with kidney diseases.

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Section: Fungal Infectionsmentioning

confidence: 99%

Infection-Induced Kidney Diseases

Prasad

Patel

2018

Front. Med.

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“…1,2 VL can involve multiple organs, including the kidneys, by different and complex mechanisms, which may lead to tubulointerstitial and glomerular changes. 3,4 Interstitial involvement is more pronounced, and it is presented mainly through tubular changes as urinary acidification deficit and reduction in urinary concentration capacity. 5,6 In humans, renal involvement is usually caused by subclinical inflammatory interstitial infiltrate induced by the parasite, and discrete changes may also occur in glomerular basal membrane.…”

mentioning

confidence: 99%

Preliminary Study on Tubuloglomerular Dysfunction and Evidence of Renal Inflammation in Patients with Visceral Leishmaniasis

Oliveira

Silva

Sampaio

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Visceral leishmaniasis (VL) is a re-emerging zoonosis of worldwide distribution. Monocyte chemotactic protein-1 (MCP-1) and malondialdehyde (MDA) are inflammation biomarkers that have never been investigated in VL. The aim of this study is to investigate the association between renal abnormalities and inflammation biomarkers in VL. This study is a preliminary prospective study with 16 VL adult patients evaluated before treatment compared with a group of 13 healthy volunteers and 5 VL patients evaluated after treatment. Urinary concentration and acidification tests were performed. MCP-1 and MDA were quantified in urine. Urinary concentration deficit was found in all VL patients before (100%) and four VL patients after (80%) treatment. Urinary acidification deficit was found in nine cases before (56.2%) and two cases after (40%) treatment. Urinary MCP-1 (374 ± 359 versus 42 ± 29 pg/mg creatinine, P = 0.002) as well as urinary MDA (5.4 ± 2.6 versus 2.0 ± 0.8 μmol/mL) showed significant differences between VL patients and controls. These data show that VL patients present urinary concentration and acidification deficit, which can persist even after specific treatment. Urinary MCP-1 and MDA are elevated in patients with VL, which suggests renal inflammation and incipient renal damage.

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“…Most common organism responsible for HUS in tropical countries includes Shigella dysenteriae in comparison to Verotoxin producing E.Coli from western countries. Schistosomiasis is an another tropical parasitic infection that can lead to kidney injury in the form of immune complex glomerulonephritis, also known as schistosomal nephropathy [40]. Fungal infections like renal mucormycosis caused by zygomycetes fungi can lead to kidney injury.…”

Section: Other Infectionsmentioning

confidence: 99%

Tropical Diseases Nephropathy - An Underemphasized Comorbidity

Aggarwal

Jain

Chhabra

2016

ARS Medica Tomitana

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The tropical areas are a home to a number of diseases because of the hot & humid climate, and lack of health care facilities. Tropical Nephropathies are a major health problem and a matter of great concern. The main causes of kidney injury in tropics are due to bacterial, viral or parasitic infections like malaria, dengue, leptospirosis, scrub typhus, acute gastroenteritis, tuberculosis, leprosy and toxic envenomations like snake bite. Renal injury associated with tropical infections has a wide spectrum of presentations ranging from acute kidney injury to chronic kidney disease. Renal involvement in infectious diseases by one or other mechanism is a definite cause of increased morbidity and mortality. Proper understanding of these diseases, early diagnosis, patient education and improved health care facilities will lead to a better outcome and improved survival. This article reviews the various tropical infections causing kidney injury including pathophysiology and line of management.

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Parasitic Kidney Disease: Milestones in the Evolution of Our Knowledge

Cited by 12 publications

References 56 publications

Infection-Induced Kidney Diseases

Infection-Induced Kidney Diseases

Preliminary Study on Tubuloglomerular Dysfunction and Evidence of Renal Inflammation in Patients with Visceral Leishmaniasis

Tropical Diseases Nephropathy - An Underemphasized Comorbidity

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