The current research of kinetostatic characteristics in flexure mechanisms mainly focus on the improvement of accuracy. To reduce or eliminate the parasitic motion is considered as an approach by using the common knowledge of symmetry. However, there is no study on designing the flexure mechanisms with symmetrical features as many as possible for better kinetostatic performance, when considering the resulting cost by the symmetry. In this paper, the concept of degree of symmetry (DoS) is proposed for the first time, which is committed to symmetry design in the phase of conceptual design. A class of flexure mechanisms with 0-DoS, 1-DoS, 2-DoS and 3-DoS are synthesized respectively based on the Freedom and Constraint Topology method. Their overall compliance matrices in an analytical form formulated within the framework of the screw theory are used to analyze and compare the effect of different number of DoS on the kinetostatic characteristics for flexure mechanisms. The finite element analysis (FEA) simulations are implemented to verify the analytical results. These results show that the higher the DoS is, the smaller the parasitic motion error will be. The flexure model with 3-DoS is optimized according to the overall compliance matrix and then tested by using the FEA simulation. The testing result shows that with the best combination parameters, the parasitic motion error for 3-DoS mechanism is almost eliminated. This research introduces a design principle which can alleviate the unwanted parasitic motion for better accuracy.