Parasitological and biochemical parameters in Schistosoma mansoni-infected mice treated with methanol extract from the plants Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban

Kamel, Erian G.; El-Emam, Mohamed A.; Mahmoud, Soheir; Fouda, Fatma M; Bayaumy, Fatma E.A.

doi:10.1016/j.parint.2011.06.016

Cited by 37 publications

(28 citation statements)

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“…[31][58] [59] With regard to the schistosomicidal action of D. ambrosioides, only the effects of methanol extracts have been investigated to date. [60] [61] In this study, DA-EO displays very promising schistosomicidal activity against Schistosoma mansoni adult worms in vitro, with LC 50 values of 6.50 AE 0.38, 3.66 AE 1.06, and 3.65 AE 0.76 lg/ml at 24, 48, and 72 h, respectively. Moreover, DA-EO was much more active than other essential oils previously investigated by our research group, which only presented significant activity only at concentrations equal to or higher than 100 lg/ml.…”

Section: Resultsmentioning

confidence: 67%

“…The use of D. ambrosioides extracts and infusions as anthelmintic and antileishmanial agents has also motivated studies on the antiparasitary activity of this species against different microorganisms, such as helmints and protozoa . With regard to the schistosomicidal action of D. ambrosioides , only the effects of methanol extracts have been investigated to date . In this study, DA‐EO displays very promising schistosomicidal activity against Schistosoma mansoni adult worms in vitro , with LC 50 values of 6.50 ± 0.38, 3.66 ± 1.06, and 3.65 ± 0.76 μg/ml at 24, 48, and 72 h, respectively.…”

Section: Resultsmentioning

confidence: 92%

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Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

Soares

Dias

Vieira

et al. 2017

Chemistry & Biodiversity

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We have investigated the chemical composition and the antibacterial activity of the essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) (DA-EO) against a representative panel of cariogenic bacteria. We have also assessed the in vitro schistosomicidal effects of DA-EO on Schistosoma mansoni and its cytotoxicity to GM07492-A cells in vitro. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS) revealed that the monoterpenes cis-piperitone oxide (35.2%), p-cymene (14.5%), isoascaridole (14.1%), and α-terpinene (11.6%) were identified by as the major constituents of DA-EO. DA-EO displayed weak activity against Streptococcus sobrinus and Enterococcus faecalis (minimum inhibitory concentration (MIC) = 1000 μg/ml). On the other hand, DA-EO at 25 and 12.5 μg/ml presented remarkable schistosomicidal action in vitro and killed 100% of adult worm pairs within 24 and 72 h, respectively. The LC values of DA-EO were 6.50 ± 0.38, 3.66 ± 1.06, and 3.65 ± 0.76 μg/ml at 24, 48, and 72 h, respectively. However, DA-EO at concentrations higher than 312.5 μg/ml significantly reduced the viability of GM07492-A cells (IC = 207.1 ± 4.4 μg/ml). The selectivity index showed that DA-EO was 31.8 times more toxic to the adult S. mansoni worms than GM07492-A cells. Taken together, these results demonstrate the promising schistosomicidal potential of the essential oil of Dysphania ambrosioides.

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Section: Resultsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 92%

Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

Soares

Dias

Vieira

et al. 2017

Chemistry & Biodiversity

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“…Egy 2011-ben megjelent tanulmányban ép-pen a Conyza dioscoridis (L.) kivonatával kezeltek Schistosoma mansonival fertőzött egereket. A sikeres kezelések-nek köszönhetően a májat érintő sarcoidosis enyhült, a granulomák sikerrel degradálódtak [13]. Jelen receptünkben is a megnevezés alapján feltehetően a féreg okozta betegséget a Conyza növényfajok egyikéből, tejből vagy az édes sörből készült laxatív hatású gyógyszer enyhítette.…”

Section: áBraunclassified

“…Ennek kiváló példája az Ebers-papirusz egyik rejtélyes receptje, amely az egyiptomi orvosi szövegek első, rendszerezett modern munkájában, a ma is alapnak tekintett Grundrißben [1] a 20. számot kapta. A sorszámozás mögött zárójelben megadott számok a papirusz eredeti oszlop-, azaz oldalszámozását, és azon belül a már modern sorszámozást adják meg, jelen esetben a 6. oldal [10][11][12][13][14][15][16]. sorát: Eb 20 (6,(10)(11)(12)(13)(14)(15)(16) Kt nt dr wrmyt m Xt: jnnk 1, psj Hr jrTt-kA Hnqt nDmt rA-pw, swj jn s r wSS=f wrmyt ntt m Xt=f.…”

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A weremit kiűzése a hasból. Óegyiptomi recept hatásosságának értelmezése az újabb kutatási eredmények alapján

2015

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Az ókori egyiptomi gyógyászatról alkotott ismereteink jelentős része az egyiptomi történelem különböző szakaszaiból fennmaradt papiruszokból származik. A leghosszabb és legátfogóbb a lipcsei Egyetemi Múzeumban őrzött Ebers-papirusz, amelyet több mint ezer évvel Hippokratész (c. Kr. e. 460-377) előtt jegyeztek le. Az Ebers-papirusz 20-as számon jelzett rejtélyes receptjében a "wrmyt" weremit hasból történő kiűzésére egy "jnnk", kopt források alapján valószínűsíthetően Conyza dioscoridis gyógynövény tejjel vagy édes sörrel készült italát ajánlják. A szerzők feltételezése szerint a weremit Schistosoma mansoni és/vagy Schistosoma haematobium cercariafertőzést jelenthet. A Conyza dioscoridis teáját a mai egyiptomi népi gyógyászatban is gyakorta alkalmazzák reuma, puffadás és görcsök ellen, illetve izzadásgátlóként, valamint külsőleg a sebgyógyulás elősegítésére. A szerzők az írásos emlékek alapján a szer hatásosságát értelmezik a modern orvosi és gyógyszerészi ismeretek segítségével. Orv. Hetil., 2015, 156(50), 2045-2051. Kulcsszavak: Ebers-papirusz, Schistosoma haematobium, Schistosoma mansoni, Conyza dioscoridis, weremit/wrmyt Removal of weremit from the abdomen Interpretation and effi cacy of an ancient Egyptian prescription by the newest scientifi c resultsSignifi cant percentage of today's knowledge of ancient Egyptian medicine has been acquired from papyri left behind from various periods of Egyptian history. The longest and the most comprehensive is the Ebers papyrus, kept in the University Museum of Leipzig, which was written more than-one thousand years before Hippocrates (c. 460-377 BC). One of the riddles among the prescriptions of the Ebers papyrus Eb20 has been used in order to remove the so called "wemyt" weremit from the abdomen with the help of a drink, which consists of "jnnk", Conyza dioscoridis in milk or sweet beer. The authors assume that the disease could be an infection of Schistosoma haematobium and/or Schistosoma mansoni. Nowadays the tea of Conyza dioscoridis is widely used as an important part of the traditional medicine against rheumatism, intestinal distention and cramps as well as an antiperspirant, and for external application to heal the wounds. The authors' intent is to interpret the effi cacy of the above-mentioned ancient prescription with the help of modern medical and pharmaceutical knowledge. ORVOSTÖRTÉNETI KÖZLEMÉNYAz ókori egyiptomi gyógyászatról alkotott ismereteink jelentős része az óegyiptomi papiruszok alapján alakult ki, amelyek az egyiptomi történelem különböző szakaszaiból maradtak fenn. A leghosszabb és legátfogóbb kö-zöttük az Ebers-papirusz. A lipcsei Egyetemi Múzeum őrzi, és nevét első tudományos feldolgozójáról és tulaj-

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“…This herb is rich in flavonoids and terpenoids (Nascimento et al, 2006). It has diverse pharmacological properties that can be applied to the treatments of influenza, cold, vomiting, skin ulceration, inflammation and tumor and as an anthelmintic (Barros et al, 2013;Monzote et al, 2007Monzote et al, , 2014Kamel et al, 2011;Gadano et al, 2006). The essential oil of Chenopodium ambrosioides L. is known for its inhibitory effect on the growth of yeast (Chekem et al, 2010), dermatophytes (Prassad et al, 2008) and other filamentous fungi (Prassad et al, 2008;Jardim et al, 2008;Sousa et al, 2012;Ávila-Blanco et al, 2014;Kumar et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of ascaridole, p‐cymene and α‐terpinene in rat plasma after oral administration of Chenopodium ambrosioides L. by GC‐MS

Yang

et al. 2015

Biomedical Chromatography

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A sensitive and reliable GC-MS method was developed and validated for the simultaneous determination of ascaridole, p-cymene and α-terpinene in rat plasma using naphthalene as internal standard. The plasma samples were extracted with ethyl acetate. Chromatographic separation was carried out on a HP-5MS capillary analytical column (30 m × 0.25 mm, 0.25 µm) and detection was performed on a quadrupole mass spectrometer detector operated under selected ion monitoring mode. The method showed excellent linearity over the investigated concentration range (r > 0.99) with the limit of quantitation down to 50, 10 and 5 ng/mL for ascaridole, p-cymene and α-terpinene, respectively. The intra-day and inter-day precisions (RSD) were <11.3%, and the accuracy was between 90.7 and 113.8%. The method was successfully applied to investigate the pharmacokinetics of Chenopodium ambrosioides L. following oral administration to rats.

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Parasitological and biochemical parameters in Schistosoma mansoni-infected mice treated with methanol extract from the plants Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban

Cited by 37 publications

References 15 publications

Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

A weremit kiűzése a hasból. Óegyiptomi recept hatásosságának értelmezése az újabb kutatási eredmények alapján

Simultaneous determination of ascaridole, p‐cymene and α‐terpinene in rat plasma after oral administration of Chenopodium ambrosioides L. by GC‐MS

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