Parastar insecticide induced changes in reproductive parameters and testicular oxidative stress biomarkers in Wistar male rats

Nantia, Edouard Akono; Kada, Antoine S; Manfo, Faustin P.T.; Tangu, Nehemiah N; Mbifung, Kaghou M; Mbouobda, Desire H; Kenfack, Augustave

doi:10.1177/0748233718761699

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…Like organochlorine exposure, there is no clear scientific evidence to support a relationship between prenatal exposure to pyrethroids, carbamates, or neonicotinoids and overweight in experimental animals. In this regard, the pyrethroid lambda cyhalothrin is associated with reproductive toxicity and degenerative damage in testes, liver, kidneys, and spleen [ 96 ] and it can cause oxidative damage to the kidney and brain of rodents [ 97 , 98 ]. Similarly, although imidacloprid promoted adipogenesis and insulin resistance [ 27 ], it was not directly associated with obesity [ 99 , 100 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

Pinos

Carrillo

Merchán

et al. 2021

IJERPH

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In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.

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Section: Discussionmentioning

confidence: 99%

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

Pinos

Carrillo

Merchán

et al. 2021

IJERPH

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“…The AR-IMI complex showed a binding free energy value that suggest a stable binding between IMI and AR. Moreover, in vivo study IMI has been demonstrated to act negatively on the male reproductive function through alteration of testosterone levels and sperm parameters [126].…”

Section: Pesticides/biocides and Plasticizersmentioning

confidence: 99%

Endocrine Disruptors and Prostate Cancer

Corti

Lorenzetti

Ubaldi

et al. 2022

IJMS

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The role of endocrine disruptors (EDs) in the human prostate gland is an overlooked issue even though the prostate is essential for male fertility. From experimental models, it is known that EDs can influence several molecular mechanisms involved in prostate homeostasis and diseases, including prostate cancer (PCa), one of the most common cancers in the male, whose onset and progression is characterized by the deregulation of several cellular pathways including androgen receptor (AR) signaling. The prostate gland essentiality relies on its function to produce and secrete the prostatic fluid, a component of the seminal fluid, needed to keep alive and functional sperms upon ejaculation. In physiological condition, in the prostate epithelium the more-active androgen, the 5α-dihydrotestosterone (DHT), formed from testosterone (T) by the 5α-reductase enzyme (SRD5A), binds to AR and, upon homodimerization and nuclear translocation, recognizes the promoter of target genes modulating them. In pathological conditions, AR mutations and/or less specific AR binding by ligands modulate differently targeted genes leading to an altered regulation of cell proliferation and triggering PCa onset and development. EDs acting on the AR-dependent signaling within the prostate gland can contribute to the PCa onset and to exacerbating its development.

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“…This pesticide is manufactured by Elanco Novartis, imported and distributed in Cameroon by FIMEX international SABP, Douala, Cameroon. The dose of Parastar (6.23 mg/kg) used in this study was according to previous studies 3,14 .…”

Section: Chemicalsmentioning

confidence: 99%

“…Previous studies suggested neurotoxic effect of Parastar evidenced by its capacity to induce anxiogenic-like, depressive-like behavior as well as impaired motor coordination in Wistar rats. The neurotoxic effect was partly attributed to pro-oxidant effect of Parastar pesticide 14,3 .…”

Section: Introductionmentioning

confidence: 99%

Momordica foetida (Cucurbitaceae) prevents behavioral impairment, motor incoordination and brain oxidative stress induced by subchronic exposure to Parastar pesticide formulation

Kada

Nantia

Chin

et al. 2022

J. Drug Delivery Ther.

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Background: Parastar is an agricultural insecticide formulation composed of two active ingredients; a pyrethroid lambda-cyhalothrin and a neonicotinoid imidachloprid used in Cameroon for vegetable protection. Previous studies showed reprotoxicity and neurotoxicity of this pesticide formulation. Momordica foetida Schumach. Et Thonn is a medicinal plant with potent antioxidant properties used traditionally in Cameroon for the treatment of several aliments. As farmers are currently exposed to Parastar pesticide formulation, this study was designed to evaluate the protective effect of M. foetida on behavioral impairment, motor incoordination and brain oxidative stress induced by subchronic administration of Parastar. Methods: The study was carried out using 40 Wistar male rats, divided into 5 groups of 8 rats each. The groups received a vehicle (distilled water; 10 mL/kg), Parastar alone (6.23 mg/kg), or concomitantly with M. foetida methanol extract (50, 100 and 200 mg/kg) for 60 days. The animals were submitted to behavioural tests including, beam walking test, open field test and forced swimming test. At end of the treatment, oxidative stress parameters and acetylcholinesterase activity were assessed in brain of each animal. Results: Parastar induced motor dysfunctions, anxiogenic like and depressive-like behaviours in the animals. The Parastar -induced alterations in behavior were all prevented by M. foetida extract. The plant extract alleviated Parstar-induced oxidative stress and alteration of cholinesterase activity, especially at the dose 100mk/kg. Conclusion: Results from this study suggest that, M. feotida methanol extract may prevent anxiety-like behavior, depressive-like behavior, motor incoordination induced by Parastar, possibly through it antioxidant properties and the preservation of acetylcholinesterase activity. Keywords: acetylcholinesterase, Momordica foetida, neurotoxicity, oxidative stress, Parastar, rats

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Parastar insecticide induced changes in reproductive parameters and testicular oxidative stress biomarkers in Wistar male rats

Cited by 13 publications

References 29 publications

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

Endocrine Disruptors and Prostate Cancer

Momordica foetida (Cucurbitaceae) prevents behavioral impairment, motor incoordination and brain oxidative stress induced by subchronic exposure to Parastar pesticide formulation

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