Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration

Salamon, Rebecca J.; Halbe, Poorva; Kasberg, William; Bae, Jiyoung; Audhya, Anjon; Mahmoud, Ahmed I.

doi:10.1016/j.isci.2023.107709

Cited by 8 publications

(2 citation statements)

References 58 publications

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“…While both the RVOT and the aortic root contain ample ganglia plexus, 15 recent study has also highlighted the crucial role of cardiac parasympathetic nerves in ventricles. 30 Thus, our study underscores the importance of cardiac ANS imbalance in the pathophysiology of RVOT-PVCs.…”

Section: Discussionsupporting

confidence: 56%

The significance of heart rate variability in patients with frequent premature ventricular complex originating from the ventricular outflow tract

Zhang,

Yu,

et al. 2023

Clinical Cardiology

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BackgroundAs an indicator of cardiac autonomic nervous activity, heart rate variability (HRV) is closely linked to premature ventricular complexes (PVCs). However, its role in patients with frequent PVCs originating from the ventricular outflow tract remains unclear.HypothesisHere, we hypothesize that there may be alterations in HRV among patients with frequent PVCs originating from the ventricular outflow tract, which could play significant roles in the management of such patients.MethodsA retrospective study was conducted, including 106 patients with frequent outflow tract PVCs and 106 healthy participants as controls. HRV was assessed based on the 24‐hour Holter recording. The originating foci of PVCs were identified during radiofrequency catheter ablation.ResultsPatients with frequent outflow tract PVCs exhibited decreased levels of high frequency (HF), standard deviation of all NN intervals, and standard deviation of the average NN intervals, but increased ratios of low frequency to HF (LF/HF ratio), even after propensity score‐matched analysis. Further investigation revealed that patients with PVCs originating from right ventricular outflow tract (RVOT) had much higher LF/HF ratios. Multivariate logistic regression analysis demonstrated that the LF/HF ratio was independently associated with PVCs originating from RVOT. Receiver operating characteristics curve indicated that the LF/HF ratio effectively determined the origin of PVCs (the area under the curve = 0.75, p < .001).ConclusionsPatients with frequent outflow tract PVCs exhibited impaired HRV. Additionally, the LF/HF ratio played a significant role in determining the origin of outflow tract PVCs.

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Section: Discussionsupporting

confidence: 56%

The significance of heart rate variability in patients with frequent premature ventricular complex originating from the ventricular outflow tract

Zhang,

Yu,

et al. 2023

Clinical Cardiology

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“…Although neuronal cells constitute less than 2.5% of human cardiac cells, they can regulate almost all physiological functions of the heart—including chronotropy, dromotropy, lusitropy, and inotropy—via the autonomic nervous system, which comprises both a sympathetic and a parasympathetic branch ( Fukuda et al, 2015 ). One study has revealed that the neonatal regenerative heart undergoes a distinctive process of physiological reinnervation, which is contingent upon collateral artery formation ( Salamon et al, 2023 ). Mahmoud et al reported that chemical sympathectomy and vagal nerve resection, despite their opposite physiological effects, can significantly regulate heart regeneration after injury in postnatal mice ( Mahmoud et al, 2015 ).…”

Section: The Extracellular Microenvironment Of Cardiomyocytes Favors ...mentioning

confidence: 99%

Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration

Zheng,

Hao,

Xia

et al. 2024

Front. Cell Dev. Biol.

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The adult mammalian cardiomyocyte has a limited capacity for self-renewal, which leads to the irreversible heart dysfunction and poses a significant threat to myocardial infarction patients. In the past decades, research efforts have been predominantly concentrated on the cardiomyocyte proliferation and heart regeneration. However, the heart is a complex organ that comprises not only cardiomyocytes but also numerous noncardiomyocyte cells, all playing integral roles in maintaining cardiac function. In addition, cardiomyocytes are exposed to a dynamically changing physical environment that includes oxygen saturation and mechanical forces. Recently, a growing number of studies on myocardial microenvironment in cardiomyocyte proliferation and heart regeneration is ongoing. In this review, we provide an overview of recent advances in myocardial microenvironment, which plays an important role in cardiomyocyte proliferation and heart regeneration.

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Spatiotemporal dynamics of mouse heart tube development

Ochandorena-Saa,

Tyser,

Meilhac

2025

Kaufman’s Atlas of Mouse Development Supplement

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Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration

Cited by 8 publications

References 58 publications

The significance of heart rate variability in patients with frequent premature ventricular complex originating from the ventricular outflow tract

The significance of heart rate variability in patients with frequent premature ventricular complex originating from the ventricular outflow tract

Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration

Spatiotemporal dynamics of mouse heart tube development

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