Parasympathetic cardiac effects in sympathectomized rats

Gizzatullin, A. R.; Gil'mutdinova, R. I.; Minnahmetov, R. R.; Ситдиков, Ф. Г.; Chiglintcev, V. M.

doi:10.1007/s10517-007-0280-y

Cited by 1 publication

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“…Both sympathetic and vagus nerves are tonically active in vivo [17]. Although both nerves produced opposing HR changes, Saman observed a vagal-dominant effect in HR changes during concurrent sympathovagal nerve stimulations [18].…”

Section: Effect Of Sympatho-vagal Interaction On Intrinsic Heart Ratementioning

confidence: 98%

Effects of sympatho-vagal interaction on ventricular electrophysiology and their modulation during beta-blockade

Chin

Allen

Brack

et al. 2020

Journal of Molecular and Cellular Cardiology

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The effects of sympatho-vagal interaction on heart rate (HR) changes are characterized by vagal dominance resulting in accentuated antagonism. Complex autonomic modulation of ventricular electrophysiology may exert prognostic arrhythmic impact. We examined the effects of concurrent sympathetic (SNS) and vagus (VNS) nerve stimulation on ventricular fibrillation threshold (VFT) and standard restitution (RT) in an isolated rabbit heart preparation with intact dual autonomic innervation, with and without beta-blockade. Methods and results: Monophasic action potentials were recorded from left ventricular epicardial surface of dualinnervated isolated heart preparations from New Zealand white rabbits (n = 18). HR, VFT and RT were measured during different stimulation protocols (Protocol 1: VNS-SNS; Protocol 2: SNS-VNS) involving low-and high-frequency stimulations. A sub-study of Protocol 2 was performed in the presence of metoprolol tartrate.In both protocols, HR changes were characterized by vagal-dominant bradycardic component, affirming accentuated antagonism. During concurrent high-frequency VNS (HV), SNS prevails in lowering VFT in a frequency-sensitive manner during low (LS) or high (HS)-frequency stimulations (HV-LS:

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Section: Effect Of Sympatho-vagal Interaction On Intrinsic Heart Ratementioning

confidence: 98%