Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation

Wang, Bin; Li, Dan; Li, Jing; An, Wei; Li, Zhilin; Shao, Qi; Qin, Lizheng

doi:10.1016/j.archoralbio.2022.105586

Cited by 1 publication

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent studies by Wang et al showed that the parasympathetic-macrophage-ductal epithelial cell axis promotes SMG regeneration in female rats after excretory duct ligation/de-ligation. Parasympathetic innervation triggers IL-6 release by regulating macrophage paracrine activity via muscarinic signaling, subsequently activating STAT3 to promote epithelial proliferation and SMG regeneration ( Wang, et al, 2023a ). The role of parasympathetic innervation in the development and regeneration of the salivary glands cannot be ignored ( Figure 6 ).…”

Section: Parasympathetic Innervation In the Salivary Gland Duct Ligat...mentioning

confidence: 99%

Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration

Wang,

Li,

et al. 2024

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

Sialadenitis and sialadenitis-induced sialopathy are typically caused by obstruction of the salivary gland ducts. Atrophy of the salivary glands in experimental animals caused by duct ligation exhibits a histopathology similar to that of salivary gland sialadenitis. Therefore, a variety of duct ligation/de-ligation models have been commonly employed to study salivary gland injury and regeneration. Duct ligation is mainly characterised by apoptosis and activation of different signaling pathways in parenchymal cells, which eventually leads to gland atrophy and progressive dysfunction. By contrast, duct de-ligation can initiate the recovery of gland structure and function by regenerating the secretory tissue. This review summarizes the animal duct ligation/de-ligation models that have been used for the examination of pathological fundamentals in salivary disorders, in order to unravel the pathological changes and underlying mechanisms involved in salivary gland injury and regeneration. These experimental models have contributed to developing effective and curative strategies for gland dysfunction and providing plausible solutions for overcoming salivary disorders.

show abstract

Section: Parasympathetic Innervation In the Salivary Gland Duct Ligat...mentioning

confidence: 99%

Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration

Wang,

Li,

et al. 2024

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation

Cited by 1 publication

References 50 publications

Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration

Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration

Contact Info

Product

Resources

About