Parasympathetic System

Pal, Gopal; Pal, Pravati; Nanda, Nivedita

doi:10.5005/jp/books/12960_33

Cited by 2 publications

(4 citation statements)

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“…[30] Increased sympathovagal imbalance leads to alteration in circulatory and immune functions. [13] In the present study, weak correlation was found between sympathovagal imbalance and IL-1α and cortisol levels. Previous studies by Czura et al reported that autonomic nervous system modifies inflammatory marker production via inflammatory reflex.…”

Section: Discussioncontrasting

confidence: 65%

“…Nerve supply from sympathetic and parasympathetic system regulate important functions of the body like circulatory, immune, excretory, reproductive, respiratory systems and metabolism. [13] Limited number of studies in RA have reported that high activity of sympathetic component leads to ventricular tachyarrhythmia and sudden death and reduced HRV in patients with heart disease is linked to elevated risk of CV incidents. [14,15] Increased levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and acute-phase reactants causes endothelial activation which alter the stability of atheromatous plaques and lead to higher CV risk in RA patients.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Sympathovagal Imbalance with Disease Activity and Inflammatory Markers in South Indian Patients with Rheumatoid Arthritis

Ganesan

Negi

Gaur

et al. 2020

IJCEP

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Background and Aim: Rheumatoid arthritis (RA) patients have higher risk of cardiovascular disease and mortality and that is not linked to traditional cardiovascular risk factors. Altered sympathovagal balance is associated with cardiovascular disease. In RA sympathovagal balance and inflammatory markers were reported to be increased, but there is inadequacy of data on its assessment and association with disease activity. This study was conducted to find the correlation of sympathovagal balance with disease activity and inflammatory markers in South Indian patients with RA. Methods: RA patients (diagnosis of RA made as per 2010 ACR/EULAR classification criteria) were enrolled from Department of Clinical Immunology, JIPMER. Participants were sub grouped as low disease activity (LDA), moderate disease activity (MDA) and severe disease activity (HDA) using disease activity score 28 with ESR. Frequency and time domain parameters of heart rate variability and inflammatory markers like Interleukin-1α (IL-1α), Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and cortisol were measured for all the participants. Results: A total of 143 RA patients (23 in LDA group, 69 in MDA group and 51 in HDA group) were assessed during the study. LF-HF ratio (ratio of low frequency power to high frequency power) a marker of sympathovagal balance showed significant increase in MDA and HDA group compared to LDA group. LF-HF ratio correlated positively with DAS28 (r=0.473, p<0.001), cortisol (r=0.363, p<0.001), IL-1α (r=0.379, p<0.05). Conclusion: Sympathovagal imbalance was significantly increased in the MDA and HDA group compared to LDA group and positively correlated with disease activity, IL-1α and cortisol in the patients of RA. Assessment of sympathovagal balance may help to find the autonomic dysfunction and cardiovascular risk in RA.

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Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Correlation of Sympathovagal Imbalance with Disease Activity and Inflammatory Markers in South Indian Patients with Rheumatoid Arthritis

Ganesan

Negi

Gaur

et al. 2020

IJCEP

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“…These responses are called autonomic responses and are executed through the autonomic part of the nervous system, known as the Autonomic Nervous System (ANS). [33] Through its innervation to all visceral organs, the ANS controls all major functions of the body, such as circulation, respiration, digestion, excretion, reproduction, immunity and metabolism. The ANS executes its functions through its two major subdivisions: the sympathetic and the parasympathetic systems.…”

Section: Sympathovagal Imbalance Concept and Its Role In Hypertensionmentioning

confidence: 99%

“…Broadly, the sympathetic system is involved in energy mobilization and utilization and the parasympathetic system in energy restoration and storage. [33] Although these divisions of the ANS are physiologically opposite, they are reciprocal to each other in their outflow and functions. Normally, the body tries to maintain a balance between the storage and utilization of energy by balancing the parasympathetic and sympathetic activities.…”

Section: Sympathovagal Imbalance Concept and Its Role In Hypertensionmentioning

confidence: 99%

Role of Sympathovagal Imbalance in Gestational Hypertension: A Mini-Review

Karthiga

Pal

Velkumary

et al. 2019

IJCEP

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Hypertension is one of the most common medical problem encountered in about 15% of pregnancies and it contributes to 12% of maternal morbidity and mortality especially in developing countries of southeast Asia. The Autonomic Nervous System (ANS) has a prominent role in the cardiovascular system adaptation to pregnancy. However, in gestational hypertension, sympathetic overactivity leads to intense vasoconstriction that results in hypertension. Current evidence suggests that sympathovagal imbalance is highly prevalent in women with Gestational Hypertension (GHT). The sympathovagal imbalance is a major cardiovascular risk in hypertensive disorders including the hypertensive disorders of pregnancy. Thus, sympathovagal imbalance is not only the physiological mechanism for genesis of hypertension in GHT, but also a major contributor to cardiovascular risk in GHT.

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Parasympathetic System

Cited by 2 publications

References 0 publications

Correlation of Sympathovagal Imbalance with Disease Activity and Inflammatory Markers in South Indian Patients with Rheumatoid Arthritis

Correlation of Sympathovagal Imbalance with Disease Activity and Inflammatory Markers in South Indian Patients with Rheumatoid Arthritis

Role of Sympathovagal Imbalance in Gestational Hypertension: A Mini-Review

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