Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder

Abstract

Children with autism spectrum disorder (ASD) experience significant difficulties with emotion regulation. Theory and empirical evidence suggest substantial biological contributions to regulatory challenges, which may be related to core ASD symptoms. Respiratory sinus arrythmia (RSA) is a measure of parasympathetic nervous system activity that serves as a putative biomarker for emotion regulation. Higher baseline RSA and more RSA reactivity (parasympathetic withdrawal; RSA-R) in response to challenge appear adaptive in non-clinical populations, but existing evidence for children with ASD remains inconclusive. The current study examined correlates of observed emotion dysregulation in 61 children with ASD between the ages of 6 and 10 years, including ASD symptom levels as well as both baseline RSA and concurrent RSA reactivity. Consistent with previous research, ASD symptom level was significantly correlated with observed dysregulation whereas additional factors such as child IQ were not. Baseline RSA was unrelated to observed dysregulation, but higher RSA reactivity predicted concurrent dysregulation above and beyond the contribution of child ASD symptoms. Findings contribute to an emerging understanding of dysregulation in these children, raise questions about the utility of traditional baseline RSA measures for this population, and clarify the functional significance of RSA reactivity as a risk factor for emotion dysregulation in children with ASD. Lay SummaryChildren with autism spectrum disorder (ASD) are at high risk for emotion dysregulation. This study identifies core ASD symptom level as important to understanding regulatory challenges, and suggests that certain biological arousal processes (e.g., the "freeing" of regulatory control to meet a challenge) may operate in a different way for this population as compared to what is generally observed for most children with neurotypical development.

Piloting a Battery to Evaluate Parasympathetic Reactivity and Externalizing Behaviors during Early Childhood in Autism Spectrum Disorder

“…Previous research in autism is mixed, with some evidence of a negative relation and some reports of no relation (Cheng et al, 2020, Neuhaus et al, 2014 In one study, the relation between RSA-R and externalizing behavior was moderated by negative parent behavior (Baker et al 2019), highlighting the complex role of social-emotional factors in the expression of externalizing behavior by autistic children. RSA-R accounted for dysregulated behaviors beyond the presence of autism features (Baker et al, 2022), and its relation to externalizing behavior depended on co-occurring sympathetic activity levels (Fenning et al, 2019). While these initial findings suggest that RSA-R is relevant for externalizing behaviors in autistic samples, more work is needed to characterize RSA in young autistic children.…”