Parathormone (PTH) is strongly related to left ventricular mass index (LVMI) in hypertensives, obese, and normal control

Assaad, Samir N.; El-Aghoury, Aliaa Ali; Elsharkawy, Eman; Elsherbiny, Tamer Mohamed; Osman, Ahmed Abdelhameed

doi:10.1016/j.ajme.2017.10.002

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Our findings are highly consistent with recent reports. [8][9][10][11][12][13][14] We found elevated serum PTH in circulation of LVH patients the finding is consistent with previous studies. 15,16 Few previous studies 17,18 suggested raised vitamin cholecalciferol levels in essential hypertension that is in disagreement with present study.…”

Section: Table-iii Correlation Of Left Ventricular Hypertrophy In Casessupporting

confidence: 91%

Cholecalciferol, serum calcium and left ventricular hypertrophy in essential hypertension.

Khalil Ahmed Memon,

Iram Jehan Balouch,

Safia Bano

2023

TPMJ

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Objective: To assess the correlation of vitamin cholecalciferol and serum calcium with left ventricular hypertrophy (LVH) in essential hypertension patients presenting at a tertiary care hospital. Study Design: Cross Sectional Comparative study. Setting: Department of Cardiology and Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh. Period: July 2019 to January 2021. Material & Methods: 100 diagnosed LVH+ Essential Hypertenison cases and 100 diagnosed essential hypertension (controls) were selected through non- probability purposive sampling. Echocardiography, serum cholecalciferol, calcium, phosphate, parathyroid hormone (PTH), alkaline phosphatase (ALP), urea and creatinine were measured form sera. Devereux’s formula measured the LV thickness LVH. SPSS ver. 21.0 analyzed the descriptive statistics and compared the variables at 95% Confidence interval (P≤0.05). Results: Serum calcium, phosphate and parathyroid hormone were found elevated in LVH cases compared to control (P=0.0001). Cholecalciferol in LVH cases was low noted as 27.3±7.84 ng/dl compared to 39.5±0.43 ng/dl in controls (P=0.0001). Cholecalciferol in mild, moderate and severe LVH cases was descending order as 30.67±7.84, 24.76±7.72 and 14.96±6.12 mm respectively (P-0.0001). Serum cholecalciferol proves inverse association (r= -0.180) with LVH (p=0.003). Conclusion: The present study reports vitamin cholecalciferol deficiency increases the chances of left ventricular hypertrophy through increased secretion of parathyroid hormone that induces de – novo protein synthesis of ventricular myocardium.

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Section: Table-iii Correlation Of Left Ventricular Hypertrophy In Casessupporting

confidence: 91%

Cholecalciferol, serum calcium and left ventricular hypertrophy in essential hypertension.

Khalil Ahmed Memon,

Iram Jehan Balouch,

Safia Bano

2023

TPMJ

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“…Було виявлено, що ПТГ пов'язаний з ІМЛШ у пацієнтів із первинним гіперпаратиреозом, кінцевою стадією ниркової недостатності з вторинним гіперпаратиреозом, ЕАГ. Зв'язок між ПТГ і ГЛШ був показаний не тільки в стані захворювання, але також для населення в цілому та людей похилого віку [1,2,3,4].…”

Section: Introduction / вступunclassified

Correlation Between the Changes in Hypertrophic Geometric Models of the Left Ventricle and Clinical, Anthropometric, Metabolic-Hormonal Parameters, and Mineral Metabolism Indicators

Voroniuk

2023

EUMJ

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Objective: to analyze the correlation between the changes in hypertrophic geometric patterns of the left ventricle and the changes in metabolic-hormonal parameters and indicators of mineral metabolism depending on the allelic state of the AGT (rs4762) and GNB3 genes in patients with essential arterial hypertension (EAH). Material and methods. The case-control study involved 100 patients with EAH stage II, 1–3 degrees of blood pressure (BP) elevation, high and very high cardiovascular risk. Among the patients, there were 21% (21) men and 79% (79) women. The mean age of patients was 59.86 ± 6.22y.o. The control group consisted of 60 apparently healthy individuals, matched on age (49.13 ± 6.28y.o.) and gender distribution (63% women, 37% men). The lipid panel parameters were measured in blood plasma, including TC (total cholesterol), ТG (triglycerides), LDL-C (low-density lipoprotein cholesterol), HDL-C (high-density lipoprotein cholesterol). All subjects were tested for serum levels of fasting glucose, ionized calcium, parathyroid (PTH) hormone, 25-hydroxyvitamin D (Vit D). Left ventricular hypertrophy (LVH) and LVH models were examined by echocardiography. Clinical and anthropometric examination methods were used in the study. Results. Eccentric left ventricular hypertrophy (ELVH) in patients with EAH was associated with higher blood pressure than concentric left ventricular hypertrophy (CLVH): systolic blood pressure and diastolic blood pressure were higher by 3.29% and 3.95%, respectively (р ≤ 0.05–0.04). ELHV was associated with higher body mass index and waist circumference (WC) in women – by 7.80% and 7.40% (р ≤ 0.05–0.048), respectively. In addition, the ELVH development was characterized by a lower level of ionized Ca2+ in the blood vs. CLVH (by 2.54%, р = 0.021), while the concentration of PTH in a compensatory manner was higher by 23.86% (р = 0.047), which indicated the calcium homeostasis intensity in EAH patients. The lipids, glucose serum concentration and Vit D level were not associated with any hypertrophic model of myocardium. Conclusions. Lipid profile, blood glucose, and Vit D concentration did not determine the development of any type of the LVH. ELVH was associated with a lower level of Ca2+ and consequently an elevated level of PTH. The formation of ELVH in patients with EAH was accompanied by a higher level of blood pressure and was also associated with higher BMI and WC.

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“…These assumptions include the independence of samples, normality and homogeneity of the data variance (Ali et al 2018). By and large, ANOVA types include one-way ANOVA, two-way Abubakar et al Bulletin of the National Research Centre (2022) 46:232 ANOVA and multivariate ANOVA (MANOVA) (Assaad et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Misuse of analysis of variance in African biomedical journals: a call for more vigilance

et al. 2022

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Background Misuse of analysis of variance alongside other statistical methods has been an important topic of discussion in many scientific gatherings. Although misuse of analysis of variance is of global concern, its prevalence in African-based biomedical journals has raised concerns among colleagues. Methods We sampled the current issues/last published issues of all African biomedical journals aggregated in an African journal aggregator. We scanned through all the journals’ sample articles in the journal aggregator and retrieved articles that either applied analysis of variance or were supposed to use the test. Results Our results show that 126 articles of the total 1789 sampled articles employed analysis of variance test for analysis. Of these, 99 (78.6%) articles used the analysis of variance test correctly, while 27 (21.4%) misused the test. Not stating the type of analysis of variance test employed for analysis was the most prevalent misuse of analysis of variance test. Conclusions In overall, the study demonstrated that misuse of analysis of variance test is prevalent in African biomedical journals. Therefore, all stakeholders (medical schools, reviewers, journal editors) need to do more to nip it in the bud.

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Parathormone (PTH) is strongly related to left ventricular mass index (LVMI) in hypertensives, obese, and normal control

Cited by 3 publications

References 26 publications

Cholecalciferol, serum calcium and left ventricular hypertrophy in essential hypertension.

Cholecalciferol, serum calcium and left ventricular hypertrophy in essential hypertension.

Correlation Between the Changes in Hypertrophic Geometric Models of the Left Ventricle and Clinical, Anthropometric, Metabolic-Hormonal Parameters, and Mineral Metabolism Indicators

Misuse of analysis of variance in African biomedical journals: a call for more vigilance

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