Parathyroid Adenoma Visualization on Octreotide Scintigraphy

Boulahdour, Hatem; Bertrand, Anne-Marie; Klingelschmitt, S.; Руденко, Б. А.; Loboguerrero, A.; Bidet, A. C.; Mantion, Georges; Cardot, J

doi:10.1097/00003072-200204000-00019

Cited by 4 publications

(6 citation statements)

References 5 publications

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“…Expression of SS receptors is variable among patients with MEN 1, being very high in the pituitary, particularly when a GH-secreting pituitary adenoma is present, and in the abdomen in most cases of GEP-NET [14] ; in the latter case, however, insulinomas frequently do not express suffi cient SS receptors to be detected by SS scintigraphy or immunohistochemistry [15] . Likewise, detection of SS receptor in the neck region of patients with PHP and MEN 1 is not a frequent fi nding at SS scintigraphy [16] . In the present study, we have investigated whether SSA therapy might help in controlling PHP in patients with MEN 1-like syndrome.…”

Section: Discussion ▼mentioning

confidence: 93%

Somatostatin Analogues do not Affect Calcium Metabolism in Patients with Acromegaly and Primary Hyperparathyroidism due to MEN 1-Like Syndrome

Bogazzi¹,

Lombardi²,

Russo³

et al. 2010

Horm Metab Res

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Patients with clinical features of MEN 1 without mutations in the menin gene fulfill the criteria of MEN1-like syndrome. Primary hyperparathyroidism (PHP) is the most frequent clinical finding in both syndromes and is usually treated by surgery. However, PHP has been reported to respond to somatostatin analogues (SSA) in MEN 1 patients. 7 patients with PHP in the context of MEN 1-like syndrome (and absence of mutations in the menin gene) were enrolled in the study and treated with SSA for 6 months for the non-PHP disease before parathyroidectomy. Serum ionized calcium, phosphorus, and PTH concentrations, and 24-h urinary calcium and phosphorus excretion were measured before and after SSA therapy. Mean serum ionized calcium, phosphorus, and PTH concentrations did not significantly change after a 6-month course with SSA. SSA scintigraphy did not reveal uptake in the neck region corresponding to the parathyroid adenoma identified at surgery and confirmed at histology. However, immunohistochemistry revealed SS-type 2A receptor in parathyroid tissue samples of 6 out of 7 patients. SSA therapy does not affect calcium-phosphorus metabolism in patients with MEN 1-like syndrome, suggesting that the drug has no role in controlling PHP in these subset of patients.

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Section: Discussion ▼mentioning

confidence: 93%

Somatostatin Analogues do not Affect Calcium Metabolism in Patients with Acromegaly and Primary Hyperparathyroidism due to MEN 1-Like Syndrome

Bogazzi¹,

Lombardi²,

Russo³

et al. 2010

Horm Metab Res

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“…In these cases, an option to be taken into account is the analysis of PTH in the FNAP of the fluid obtained from the cyst [16], although it can cause bruising and there is a risk of parathyromatosis, which is why we do not perform it. Octreoscan, R. Alfonso-Ballester et al DOI: 10.4236/jct.2018.911070 855 Journal of Cancer Therapy which can detect ectopic adenomas if they express somatostatin receptors, may also be helpful [17]. The CT scan and the MRIcan also may be useful to complete the preoperative study.…”

Section: Discussionmentioning

confidence: 99%

Giant Cystic and Mediastinal Parathyroid Adenoma with Non-Uptake in Scintigraphy

Ballester¹,

Moreno²,

Fernández³

et al. 2018

JCT

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Introduction: In 85% of patients, the cause of Primary Hyperparathyroidism (PHPT) is an adenoma. Parathyroid adenoma localization is usually simple. 96% of localizations prior to surgery are achieved with ultrasound and scintigraphy combination. Difficulties can appear. If the gland is not located in a cervical position and has no uptake in scintigraphy but there is high suspition of an adenoma causing the PHPT, some extra tests should be considered. Case Report: We present a case of giant cystic mediastinal adenoma, a quite rare condition, which was diagnosed as a thyroid colloid cyst by ultrasound, and was not localized by scintigraphy. We report the CT scan and the magnetic resonance imaging (MRI) images that show the tumour. It was surgically resected by a cervical approach. After the excision, the patient recovered normal levels of Calcium and Parathormone (PTH). Conclusion: We review literature about cystic and mediastinal adenomas and diagnostic methods when the standard ones do not give an accurate localization diagnosis.

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“…Given that some parathyroid adenomas are positive on SRS ( 4 - 6 ), we next performed SRS with SPECT/CT to identify the PHPT-responsible lesion. As shown in Fig.…”

Section: Case Reportmentioning

confidence: 99%

“…However, such noninvasive imaging approaches yield nonlocalizing results in 12% to 18% of patients with PHPT ( 1 - 3 ). There have been only few case reports of PHPT in which somatostatin receptor scintigraphy (SRS) was used to identify cervical parathyroid adenomas ( 4 - 6 ). However, the superiority and benefit of SRS over 99m Tc-MIBI scintigraphy remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Mediastinal Cystic Parathyroid Adenoma Diagnosed by Somatostatin Receptor Scintigraphy

et al. 2021

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A 71-year-old man complained of nausea and loss of appetite for eight months prior to admission. He was transported to a hospital with disorientation and diagnosed with primary hyperparathyroidism by laboratory examinations. However, ultrasonography, computed tomography, and technetium-99m labeled methoxyisobutyl isonitrile ( 99m Tc-MIBI) with single-photon emission computed tomography did not yield definite results. In contrast, somatostatin receptor scintigraphy successfully identified the lesion responsible for the over-secretion of parathyroid hormone within the middle mediastinum. The tumor was successfully resected by surgery, and a histopathological analysis confirmed the parathyroid adenoma nature of the tumor.

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Parathyroid Adenoma Visualization on Octreotide Scintigraphy

Cited by 4 publications

References 5 publications

Somatostatin Analogues do not Affect Calcium Metabolism in Patients with Acromegaly and Primary Hyperparathyroidism due to MEN 1-Like Syndrome

Somatostatin Analogues do not Affect Calcium Metabolism in Patients with Acromegaly and Primary Hyperparathyroidism due to MEN 1-Like Syndrome

Giant Cystic and Mediastinal Parathyroid Adenoma with Non-Uptake in Scintigraphy

Mediastinal Cystic Parathyroid Adenoma Diagnosed by Somatostatin Receptor Scintigraphy

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