Parathyroid Cancer - Occurrence, Diagnosis, Treatment

Gawrychowski, Jacek; Kowalski, Grzegorz; Gawrychowska, Agata

doi:10.2478/v10035-008-0072-8

Cited by 8 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preoperative pharmacological treatment in patients with severe hypercalcaemia initially includes intensive hydration using isotonic sodium chloride solution [10,22]. After the correction of fluid deficiencies, the treatment is continued in combination with loop diuretics and simultaneous correction of potassium and magnesium deficiencies.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of patients with primary hyperparathyroidism with a risk of hypercalcaemic crisis

Buła

Kowalski

Koziołek

et al. 2020

Endokrynologia Polska

Self Cite

View full text Add to dashboard Cite

Introduction: The objective of the work was to evaluate the effectiveness of surgical treatment in patients with a high risk of hypercalcaemic crisis due to primary hyperparathyroidism (PHPT) and to determine the best time to undergo surgery. Material and methods and Results: Between 2010 and 2019, 627 patients underwent surgery due to PHPT. Sixty-two patients (9.9%) (47 women and 15 men, aged 28-79 years, average 53.7 years) faced the threat of a parathyroid crisis. In these patients, the average parathyroid hormone (PTH) levels were 774.02 pg/mL (95% CI: 203-1246 pg/mL) and ionised calcium (iCa2+) 1.91 mmol/L (95% CI: 1.70-2.2 mmol/L). The PTH postoperative concentration averaged at 37.86 pg/mL (95% CI: 9.91-42.7 pg/mL) and iCa2 + 1.11 mmol/L (95% CI: 1.07-1.21 mmol/L). Bilateral neck exploration was performed in all patients with the removal of the affected parathyroid gland and biopsies of other parts. Histopathological examination revealed adenoma in 42 cases (67.7%), hyperplasia in 16 (25.7%), and parathyroid cancer in four of the patients (6.6%). Comparison of tests before and after surgery showed a statistically significant decrease in PTH (p < 0.001) and iCa (p < 0.001) in blood serum. Conclusions: A developing hypercalcaemic crisis in the course of hyperparathyroidism is an indication for preoperative intensive medical therapy, along with urgent surgical intervention and removal of diseased parathyroid glands. This type of surgery should be performed as soon as possible, even if there are no imaging tests, only based on an assessment of the general condition of the patient and their serum calcium levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Surgical treatment of patients with primary hyperparathyroidism with a risk of hypercalcaemic crisis

Buła

Kowalski

Koziołek

et al. 2020

Endokrynologia Polska

Self Cite

View full text Add to dashboard Cite

show abstract

“…Primary hyperparathyroidism usually caused by parathyroid adenoma, parathyroid hyperplasia or rarely parathyroid carcinoma (PTC) (1). PTC accounts for 0.4% to 5.2% of all reported cases of hyperparathyroidism, which is approximately 0.2% to 0.5% of malignant endocrine tumors overall (2). The suspicion of malignancy should be in the setting of high calcium level more than 14mg/dl and high parathyroid hormone (PTH) level (>five times of upper normal).…”

Section: Discussionmentioning

confidence: 99%

Parathyroid carcinoma presenting with type 1 renal tubular acidosis

Priyankara

Arulmoly

Jayasinghe

et al. 2018

Sri Lanka J. Diabetes Endocrinol. Metab.

View full text Add to dashboard Cite

Primary hyperparathyroidism usually caused by parathyroid adenoma, parathyroid hyperplasia or rarely parathyroid carcinoma (PTC). PTC accounts for 0.4% to 5.2% of all reported cases of hyperparathyroidism, which is approximately 0.2% to 0.5% of malignant endocrine tumors overall. Renal tubular acidosis has been reported to be associated with primary hyperparathyroidism. We report a case of parathyroid carcinoma diagnosed with only using the minor criteria who had concurrent renal tubular acidosis. This case highlights the importance of keeping the suspicion of PTC in mind when clinically hypercalcemic patients presented with abnormally high serum calcium levels.

show abstract

“…HPT is usually caused by benign parathyroid adenomas, parathyroid hyperplasia and, rarely, parathyroid carcinoma (PC). PC accounts for less than 5% of all reported cases of HPT, which is approximately 0.5% of endocrine cancers overall 1. PC is one of the rarest of all human cancers.…”

Section: Introductionmentioning

confidence: 99%

Previously unreported deletion of CDC73 involving exons 1–13 was detected in a patient with recurrent parathyroid carcinoma

Mahajan¹,

Sacerdote

2018

BMJ Case Rep

View full text Add to dashboard Cite

Parathyroid carcinoma (PC) is a rare malignancy, presenting sporadically or as part of a genetic syndrome. Diagnosis of PC includes the histopathological diagnosis based on capsular, perineural, or vascular invasion or metastasis. High suspicion for malignancy includes hypercalcaemia greater than 14 mg/dL, extremely high serum parathyroid hormone (PTH) levels, as well as large masses. Given the rarity of PC, it is challenging to design clinical trials for newer therapy. Currently, complete initial surgical excision of the tumour in high-risk patients offers the best chance of cure and prolonged disease-free survival in PC. In the absence of definite data, non-surgical therapies such as radiation and chemotherapy are not routinely recommended. For early detection of recurrence; long-term clinical follow-up with interval measurements of serum calcium and PTH is recommended. Localising studies of PC are helpful. Early screening for CDC73 mutation and multidisciplinary treatment by an endocrine/ENT/surgical oncology team is recommended.

show abstract

Parathyroid Cancer - Occurrence, Diagnosis, Treatment

Cited by 8 publications

References 48 publications

Surgical treatment of patients with primary hyperparathyroidism with a risk of hypercalcaemic crisis

Surgical treatment of patients with primary hyperparathyroidism with a risk of hypercalcaemic crisis

Parathyroid carcinoma presenting with type 1 renal tubular acidosis

Previously unreported deletion of CDC73 involving exons 1–13 was detected in a patient with recurrent parathyroid carcinoma

Contact Info

Product

Resources

About