Parathyroid carcinoma: clinical presentation and treatment

Jakoubková, S; Vokůrka, J; J, Cáp; Ryška, Aleš

doi:10.1016/s0531-5131(03)00744-1

Cited by 8 publications

(28 citation statements)

References 8 publications

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“…4,14 Frozen-section analysis is of little value, especially for well-differentiated lesions, because it is often diffi cult to distinguish between adenomatous, hyperplastic, and malignant lesions. 5,7,9,13 Frozen section was not helpful in our patient. The most effective treatment is en bloc resection of the primary lesion.…”

Section: Discussionmentioning

confidence: 59%

“…Parathyroid carcinoma is a rare neoplasm that develops in 0.1%-5% of patients with primary hyperparathyroidism. [1][2][3][4][5][6][7][8][9][10][11][12][13] The National Cancer Database registered 286 cases treated in the United States between 1985 and 1995, representing an incidence of 0.005% of all registered cancer cases in the United States during that period. 10,14 The etiology is unknown and until now, there was no evidence that parathyroid adenoma predisposes to parathyroid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…This procedure involves ipsilateral thyroid lobe resection, reducing the risk of tumor cell spillage and achieving better local disease control, lower recurrence rates, increased survival rates, and resolution of symptoms related to tumor and hypercalcemia. 1,3,4,[7][8][9]11,12,14,15 This surgical procedure has a 50% cure rate. 7,18 Koea et al reported a 10% local failure rate and 90% long-term survival rate.…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy for parathyroid carcinoma is usually ineffective. 4,8,9,11,14 Some studies have shown survival rates of 85.5% and 49% at 5 and 10 years, respectively. 7,14,16 Another study attributed 5-and 10-year survival rates of 85% and 77%, respectively, to better medical support and hypercalcemia control.…”

Section: Discussionmentioning

confidence: 99%

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Use of a gamma probe to identify and guide resection of recurrent parathyroid carcinoma: Report of a case

et al. 2011

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Parathyroid carcinoma (PC) accounts for less than 0.005% of all cancers and less than 5% of causes of hyperparathyroidism. This tumor is difficult to identify during surgery, which is detrimental to the oncologic results. Surgery is still the main treatment for the primary tumor and to control parathyroid hormone levels after recurrence. We report a case of recurrent parathyroid carcinoma in a 30-year-old man, identified and managed with the use of a gamma probe during surgery. To our knowledge, this is only the second report of a gamma probe being used to guide resection of a recurrent PC. We discuss the diagnosis and treatment, analyzing the current evidence-based literature.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Use of a gamma probe to identify and guide resection of recurrent parathyroid carcinoma: Report of a case

et al. 2011

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“…2 The characteristic symptoms of hyperparathyroidism include bone pain, fractures and renal colic. 1,2,4,5 Nephrolithiasis occurs in up to 56% of patients, and renal failure in 84%. 6 Most patients with parathyroid carcinoma die of metabolic complications due to primary hyperparathyroidism.…”

Section: Clinical Featuresmentioning

confidence: 99%

Parathyroid Carcinoma, a Rare Entity with Varying Presentation and Treatment

Haar¹,

Shen²,

Valk³

et al. 2010

World Journal of Endocrine Surgery

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Background: Parathyroid carcinoma is a rare entity that has diverse presentation and diverse treatments. This case-series highlights the atypical and diverse presentation of parathyroid carcinoma and stresses the importance of the diagnostic approach and intraoperative strategy. Methods: We report three patients with parathyroid cancer. Results: In one patient, a parathyroid lesion was found to be a parathyroid carcinoma intraoperatively, resulting in a change of operative strategy. In another, parathyroid carcinoma was suspected preoperatively and was treated accordingly. A third patient presented with an already a metastasized parathyroid carcinoma. Conclusion: The diagnostic approach and intraoperative strategy are instrumental to determining the best treatment and yielding the best outcome.

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