Parathyroid Carcinoma in a Mediastinal Sixth Parathyroid Gland

Kelly, Michael D.; Sheridan, Brian; Farnsworth, Alan; Palfreeman, Simon

doi:10.1111/j.1445-2197.1994.tb02251.x

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…Rarely, PCA develops in ectopic glands in mediastinal locations [20]. In the majority of cases, PCA arises in a single gland, but multiple carcinomas have been reported [21].…”

Section: Natural Historymentioning

confidence: 99%

Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics

2010

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After completing this course, the reader will be able to:1. Discuss the association of parathyroid cancers with severe hypercalcemia and markedly elevated parathyroid hormone levels.2. Describe the effect of the risk factors, clinical presentation, and gene expression on diagnosis of parathyroid cancers.3. Analyze the probability of cure for parathyroid cancers with treatment by aggressive surgery with en bloc resection and lymph node dissection.This article is available for continuing medical education credit at CME.TheOncologist.com. The Oncologist CME Program is located online at http://cme.theoncologist.com/. To take the CME activity related to this article, you must be a registered user. CME CME ABSTRACT EndocrinologyThe

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“…Rarely, PCA develops in ectopic glands in mediastinal locations [20]. In the majority of cases, PCA arises in a single gland, but multiple carcinomas have been reported [21].…”

Section: Natural Historymentioning

confidence: 99%

Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics

2010

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“…Second, throughout the whole course of the disease, the patient prominently manifested with recurrent acute pancreatitis, the incidence of which in hyperparathyroidism is only 1.47% (44), and there is only one report of acute pancreatitis associated with the mediastinal parathyroid carcinoma (6). The last but not the least, (10,12,18,27,30) was reported in pmol/L unit, and was changed into pg/ml unit based on the formula (pmol × 9.43 = pg/ml), according to the Matejek et al (36). C-terminal PTH measured in some literatures (19,29) was not recorded in this along with her recurrence, this patient suffered from persistent hypercalcemic crisis.…”

Section: Resultsmentioning

confidence: 99%

“… c Pre → Post- = the serum levels of calcium and PTH before and after the treatment (operation or chemotherapy). Intact PTH value in some literatures ( 10 , 12 , 18 , 27 , 30 ) was reported in pmol/L unit, and was changed into pg/ml unit based on the formula (pmol × 9.43 = pg/ml), according to the Matejek et al ( 36 ). C-terminal PTH measured in some literatures ( 19 , 29 ) was not recorded in this table .…”

Section: Methodsmentioning

confidence: 99%

Persistent Hypercalcemia Crisis and Recurrent Acute Pancreatitis Due to Multiple Ectopic Parathyroid Carcinomas: Case Report and Literature Review of Mediastinal Parathyroid Carcinoma

et al. 2020

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Mediastinal parathyroid carcinoma (PC) is a rare entity in primary hyperparathyroidism. The aim of this report is to demonstrate a case of mediastinal PC, and to provide a systemic literature review of this rare condition. A 34-year-old woman who had already undergone two cervical operations for hyperparathyroidism suffered from another recurrence, presenting with recurrent acute pancreatitis and persistent hypercalcemic crisis. Technetium-99 methoxyisobutylisonitrile imaging (MIBI) and computed tomography scanning (CT) identified three possible parathyroid tumors, one of which was the recurrence of residual tumor locating in the thyroid region, while the other two were ectopic tumors locating in the suprasternal fossa and thymus region, respectively. Pathological examination confirmed the diagnosis of PC. We conducted a systemic literature review by searching the PubMed MEDLINE from 1951 to 2019 for studies of all types in the English language only, using terms "mediastinal, mediastinum, parathyroid, carcinoma." Including our reported case, a total of 21 cases with ectopic mediastinal PCs were assessed for demographic data, tumor location and size, biochemical findings, and symptomatology, etc. Two thirds of the patients were men, with a mean age of 44 years old, a mean serum calcium of 14.2 mg/dl, and a mean serum intact parathyroid hormone of 1,216 pg/ml. We identified 89.5% of carcinomas in the anterosuperior mediastinum, and 10.5% in the middle mediastinum, with a mean diameter of 54 mm, and a mean weight of 216 g. MIBI and CT were the most commonly used methods to localize these mediastinal tumors, with 69.2 and 100% sensitivity, respectively. Half of the patients underwent more than one operation. Diagnosis and treatment of mediastinal PCs represent a challenge. Early suspicion, appropriate preoperative localization studies, and the cooperation of endocrinologists and surgeons are crucial in the effective management.

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“…Functional or nonfunctional parathyroid carcinoma of the mediastinum is a very rare phenomenon. [5][6][7] The origin of this tumor is presumed to be an ectopic or supernumerary parathyroid gland located in the anterosuperior mediastinum. This occurrence is not surprising, given the close association between the parathyroid glands and the thymus during embryogenesis, in the sense that both the thymus and the inferior parathyroid glands originate from the third branchial pouch.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal Parathyroid Carcinoma With Tumor Implants in a Child: A Unique Occurrence

2008

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Parathyroid Carcinoma in a Mediastinal Sixth Parathyroid Gland

Cited by 12 publications

References 13 publications

Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics

Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics

Persistent Hypercalcemia Crisis and Recurrent Acute Pancreatitis Due to Multiple Ectopic Parathyroid Carcinomas: Case Report and Literature Review of Mediastinal Parathyroid Carcinoma

Mediastinal Parathyroid Carcinoma With Tumor Implants in a Child: A Unique Occurrence

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