Parathyroid carcinoma in chronic renal disease – a case series of three patients and review of literature

Živaljević, Vladan; Zívić, R; Slijepčević, Nikola; Buzejic, Matija; Dundjerović, Duško; Stanković, Jasna Trbojević; Stojakov, Dejan; Jovanović, Milan; Paunović, Ivan

doi:10.1080/00015458.2021.1970438

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Clinical characteristics of patients on hemodialysis who happen to develop parathyroid carcinoma vary widely and have still not been understood completely (Zivalijevic et al 2021). In the literature, there are 36 cases published to date of patients on hemodialysis who have been diagnosed with parathyroid carcinoma (24; 10, 15); The mean age of those patients at diagnosis is 49.4 years.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid Carcinoma in a Young Patient with End-Stage Renal Disease: A Case Report from Oman

Al Hosni

2022

JCSR

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Parathyroid carcinoma is an extremely rare malignancy, accounting for less <0.005% of all cancers and <1% of parathyroid disorders. Pre-operatively, it can be suspected from the tumor size, which usually exceeds 4cm, as well as a high parathyroid hormone (PTH). However, histopathological features confirm the diagnosis. The main objective of treatment is en block resection of the tumor, with excision of the ipsilateral thyroid. We describe a young female with end-stage renal disease (ESRD) who got diagnosed with parathyroid carcinoma. Ultrasound (US) and Sestamibi scans were both suggestive of parathyroid adenoma. Post-operatively, histopathological diagnosis of the specimen revealed parathyroid carcinoma. We introduce this case that was initially suspected to be parathyroid adenoma until histopathological diagnosis revealed parathyroid carcinoma. Patients with ESRD and hypercalcemia with sky-high PTH may have the suspicion for parathyroid carcinoma masked as those lab results can commonly get attributed to the ESRD.

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Section: Discussionmentioning

confidence: 99%

Parathyroid Carcinoma in a Young Patient with End-Stage Renal Disease: A Case Report from Oman

Al Hosni

2022

JCSR

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Cohort review of patients with parathyroid cancer in End Stage Renal Disease (ESRD)

Zheng,

Lee,

Parameswaran

2024

Langenbecks Arch Surg

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Predictive Ability of Rule of 3 in Parathyroid Cancer: Outcomes from a South Asian Cohort

Pinto,

Dhanda,

Agarwal

et al. 2024

Oncology

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Background Preoperative diagnosis of parathyroid cancer (PTTC) where possible allows for en-bloc resection of the tumour, which is associated with excellent prognosis. The rule of > 3 (size of tumour larger than 3cm; corrected calcium more 3mmol/L) as proposed by Schulte and Talat, has a specificity of 95% in predicting malignancy in parathyroid neoplasms. We looked at the impact of rule of 3’s in predicting malignancy and outcomes on intervention in a South Asia cohort. Methods Patients who underwent parathyroid surgery between 2010 – 2023 at two tertiary referral centres were assessed. Patients with PTTC were selected and their clinicopathological parameters, treatment modalities, and outcomes were analyzed. Results 13 of 336 (3.8%) patients with a mean age of 61.8 (+/-17.5) years was diagnosed with PC during the study period. The highest mean preoperative values were: PTH (92.4+/-66.27 pmol/L), highest corrected calcium (3.21+/- 0.28 mmol/L) and alkaline phosphatase (419 IU/ml). Nine patients underwent en bloc excision while the other had focussed parathyroidectomy. Recurrences were recorded in 2 (28.5%) patients over a mean follow up period of 69 (+/-48.6) months. One patient with lung metastasis underwent video assisted thoracic surgery (VATS). There was no disease specific mortality in this cohort during the study period. Conclusions In our experience, the predictive rule of 3’s has low sensitivity to suspect parathyroid cancer preoperatively, resulting in limited usefulness in clinical practice. Outcomes appear to be less favourable with higher recurrence rates in cases where less than enbloc resection is performed.

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Parathyroid carcinoma in chronic renal disease – a case series of three patients and review of literature

Cited by 3 publications

References 26 publications

Parathyroid Carcinoma in a Young Patient with End-Stage Renal Disease: A Case Report from Oman

Parathyroid Carcinoma in a Young Patient with End-Stage Renal Disease: A Case Report from Oman

Cohort review of patients with parathyroid cancer in End Stage Renal Disease (ESRD)

Predictive Ability of Rule of 3 in Parathyroid Cancer: Outcomes from a South Asian Cohort

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