2023
DOI: 10.1007/s12020-023-03376-w
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Parathyroid carcinoma: molecular therapeutic targets

Francesca Marini,
Francesca Giusti,
Gaia Palmini
et al.
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Cited by 5 publications
(5 citation statements)
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“…It usually presents as a sporadic tumor, but occasionally occurs in individuals with hereditary PHPT, leading to life-threatening hypercalcemia due to excessive production of PTH ( 5 , 19 ). Preoperative serum calcium exceeding 3 mmol/L with PTH over three times the upper limit of normal and parathyroid lesions larger than 3 cm, referred to as the “>3+>3+>3 principle”, strongly suggests the possibility of PC ( 5 , 8 , 20 ). Nevertheless, histopathologic tissue biopsy remains the gold standard.…”
Section: Discussionmentioning
confidence: 99%
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“…It usually presents as a sporadic tumor, but occasionally occurs in individuals with hereditary PHPT, leading to life-threatening hypercalcemia due to excessive production of PTH ( 5 , 19 ). Preoperative serum calcium exceeding 3 mmol/L with PTH over three times the upper limit of normal and parathyroid lesions larger than 3 cm, referred to as the “>3+>3+>3 principle”, strongly suggests the possibility of PC ( 5 , 8 , 20 ). Nevertheless, histopathologic tissue biopsy remains the gold standard.…”
Section: Discussionmentioning
confidence: 99%
“…The CDC73 mutation, resulting in the deletion of parafibromin, is found in approximately 70% of sporadic PC cases and only about 2% of PA cases, indicating a high risk of recurrence, metastasis, and mortality ( 23 ). Loss of parafibromin is emerging as a more promising predictor of adverse outcomes than mutation ( 5 , 20 ). Therapeutically, surgery is a crucial prognostic determinant, with limited effects of radiotherapy and chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
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“…Notably, the involvement of mTORC1 signaling extends to the realm of parathyroid gland biology. Genomic alterations in the PI3K/AKT/mTOR and Wnt signaling pathways have been associated with parathyroid carcinoma (3941). Moreover, mutations in the Tsc1 gene, leading to mTORC1 hyperactivation, correlate with enlarged parathyroid glands and elevated serum PTH levels (42, 43).…”
Section: Discussionmentioning
confidence: 99%
“…However, parathyroid carcinoma has been described as well, and although it is a rare disease in the general population [16], it occurs at much higher rates in patients with HJT than non-HJT individuals [17,18]. While no multidisciplinary guideline specifically addresses the issue of HJT, the current recommendations for HJT-related PHP include an early parathyroidectomy due to the elevated risk of a parathyroid carcinoma under these specific circumstances [19,20]. Considering that prompt recognition of genetic PHP is the key to timely diagnosis of high-risk tumours such as HJT-associated parathyroid carcinomas, molecular and immunohistochemistry markers are essential and serve as prognostic markers amid our modern era of combined endocrine-genetic-surgery approaches [20,21].…”
Section: Introductionmentioning
confidence: 99%