Parathyroid glands: combination of sestamibi-99mTc scintigraphy and ultrasonography for demonstration of hyperplasic parathyroid glands

Usefulness of the combination of ultrasonography and 99mTc‐sestamibi scintigraphy in the preoperative evaluation of uremic secondary hyperparathyroidism

“…[28][29][30][31][32] It is useful to be reminded that the operators of each of the imaging techniques were blind to the results of the other exam. Thus, it is possible that the sensitivity and specificity are underestimated.…”

“…[50][51][52] Such association is considered casual and similar to that of the general population. 15,53,54 However, it is well known that the detection of abnormal PTGs by both ultrasonography and scintigraphy may be impaired in the presence of nodular 28,55,56 or multinodular thyroid disease. 16,39 Indeed, we did not find significant differences in the sensitivity of ultrasonography and scintigraphy between SHPT with and without concomitant thyroid disease.…”

“…12 Indeed, studies on the role of 99mTc sestamibi in SHPT have led to conflicting results [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] ; likewise for studies that have combined ultrasonography and sestamibi scintigraphy. [28][29][30][31][32] The present study aimed at assessing the sensitivity and specificity of the combination of high-resolution ultrasonography and 99mTc sestamibi dual-phase scintigraphy in the preoperative localization of PTG as well as at evaluating their usefulness in surgical decision-making in hemodialysis patients with SHPT referred for first parathyroid surgery.…”

99mTc-MDP bone uptake in secondary hyperparathyroidism: comparison of the mandible, cranium, radius, and femur

“…2,12,15,22 The increased uptake of radiolabeled phosphate occurs mainly in bone areas in which altered collagen metabolism and increased bone calcium turnover occur. 23,24 Parathyroid gland surgery is an effective treatment for these patients, 25,26 although complete bone healing takes a long time. Bone scintigraphy is a sensitive, noninvasive technique that can be used to follow these patients.…”

Dual-phase 99mTc-MIBI scintigraphy to assess calcimimetic effect in patients on haemodialysis with secondary hyperparathyroidism

“…Imaging of the parathyroid glands using 99m Tc-MIBI has been widely used in the identification of solitary parathyroid adenomas, which is the most common finding in patients with primary hyperparathyroidism [7,8]. Some groups indicate that 99m Tc-MIBI imaging can also be used initially to localize abnormal glands in haemodialysis patients with secondary hyperparathyroidism, before ultrasound, magnetic resonance and computed tomography in preoperative parathyroidectomy patients [9][10][11][12][13]. However, the need for imaging in such patients is still debatable because of the low sensitivity in the detection of hyperplastic multiglandular disease.…”