Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits

Huh, Jisun; Jung, Ui Won; Park, Kyeong Mee; Kim, Hyun Sil; Kim, Kee Deog; Park, Wonse

doi:10.1155/2017/6087676

Cited by 4 publications

(7 citation statements)

References 39 publications

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“…In our experiments, PTH was administered at 10 μg kg −1 day −1 for 5 weeks (from 1 week before sinus surgery to 4 weeks after sinus surgery) to investigate the effect at a minimum dose over a minimum period. Huh et al () performed bone augmentation in the healthy rabbit sinus, and PTH was injected subcutaneous at a dose of 10 μg/kg for either 2 or 4 weeks, with the comparison showing that bone formation was greater after 4 weeks of administration. However, no significant difference was found between the PTH and saline groups.…”

Section: Discussionmentioning

confidence: 99%

“…Histomorphometric analysis of the detail area revealed that the NBA of window was significantly higher than center. This result was in both experimental and control groups and the same results in previous studies (Huh et al, ; Iida et al, ). This implies that the new bone grew earlier around the graft material near the cortical bone.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies of the effect of PTH at the bone graft site employed allografts or autografts of the long bone (Daugaard et al, 2011;Takahata, Schwarz, Chen, O'Keefe, & Awad, 2012b), spine fusion (Abe et al, 2007), and calvarial defects (dos Santos et al, 2016;Sheyn et al, 2013). Huh et al (2017) is the only previous study to have investigated the effect of PTH on the sinus bone graft model. In contrast to most of the previous studies of bone grafting using autografts or allografts, the present study applied xenografts to rabbits.…”

Section: Discussionmentioning

confidence: 99%

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Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Dam

Jung

Park

et al. 2020

Clinical Oral Implants Res

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Objectives The purpose of this study was to determine the effect of administering intermittent parathyroid hormone 1–34 [teriparatide, (PTH)] on the maxillary sinus lift and bone grafting in osteoporotic rabbits induced by ovariectomy and glucocorticoid. Materials and methods Ovariectomies were performed on 20 female New Zealand white rabbits that were randomly divided into two groups: (a) the PTH group (n = 10), in which 10 μg kg−1 day−1 PTH was injected subcutaneously 5 days a week for 5 weeks (from 1 week before until 4 weeks after sinus surgery), and (b) the saline group (n = 10), in which saline substituted PTH at the same dose, mode of administration, and duration. Bone grafting with bovine bone mineral was augmented into 13 sinuses, and bone grafts and implants were simultaneously performed in seven sinuses, in both groups. Animals were sacrificed at 4 weeks after surgery. To determine whether PTH was an effective treatment for osteoporosis, we measured the bone mineral density (BMD) of the right femur using micro‐computed tomography and performed radiographic and histometric analyses of the maxillary sinus surgery site. The Mann–Whitney test was used for statistical analysis. Results It was found that BMD increased in the femur, whereas none of the radiographic and histometric parameters differed significantly between the groups in the sinus, while there were large interindividual variations within groups. Conclusions These findings suggest that intermittent PTH does not promote new bone formation in the augmented maxillary sinus of ovariectomized rabbits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Dam

Jung

Park

et al. 2020

Clinical Oral Implants Res

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“…The protocol used in this study for μCT analysis was similar to previous studies (Shiels et al, 2012). At 8 weeks (Huh et al, 2017;Kuroshima, Yasutake, Tsuiki, Nakano, & Sawase, 2015;Mashiba et al, 2001;Wen et al, 2015) after surgery (post-euthanasia) for bone remodeling assessment, μCT images were taken using a Skyscan 1076 (Kontich, Belgium) with 8.77 μm resolution. The femurs were fixed using a 10% formaldehyde solution.…”

Section: Micro-ct (μCt) Characterizationmentioning

confidence: 99%

In vivo hydroxyapatite scaffold performance in infected bone defects

et al. 2019

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Critically sized bone defects are often compounded by infectious complications. The standard of care consists of bone autografts with systemic antibiotics. These injuries and treatments lead to donor site morbidity, antibiotic resistant strains of bacteria, and often end stage amputation. This study proposes an alternative to the autograft using a porous, hydroxyapatite (HA) scaffold evaluated with and without infection and antibiotics. Twenty‐four New Zealand white rabbits received either our HA scaffold or a pulverized autograft (PBA) within a surgically created critical‐sized defect in the femur. The two grafts were evaluated in either septic or aseptic defects and with or without antibiotic treatment. The HA scaffolds were characterized with micro computed tomography. Post‐euthanasia, micro computed tomography, histology, and white blood cells component analysis were completed. The HA had significantly greater (p < .001) mineralization to total volume than the PBA groups with 27.56% and 14.88%, respectively, and the septic HA groups were significantly greater than the aseptic groups both with and without antibiotics (p = .016). The bone quality denoted by bone mineral density was also significantly greater (p < .001) in the HA groups (67.01 ± 0.38 mgHA/cm3) than the PBA groups (64.66 ± 0.85 mgHA/cm3). The HA scaffold is a viable alternative to the bone autograft in defects with and without infection as shown by the quality and quantity of bone.

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“…Many treatment options have been considered to overcome these issues. Studies have suggested that non‐surgical maxillary treatments such as hyperbaric oxygen (HBO) and parathyroid hormone (PTH) can be used to treat bone diseases in which osteogenic potential is severely impaired (Huh et al, ; Mericske‐Stern et al, ) and also in cases where a poor prognosis is expected even after use of bone graft materials (Atalay et al, ; Bashutski et al, ; Cheung & Seeman, ; Gerard, Carlson, Gotcher, & Pickett, ; Scoletta, Arduino, Reggio, Dalmasso, & Mozzati, ; Vescovi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of hyperbaric oxygen therapy with PTH [1–34] on calvarial bone graft in irradiated rat

Park

Choi

et al. 2019

Oral Diseases

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Objective:To determine the synergistic effect of parathyroid hormone (PTH) in combination with hyperbaric oxygen (HBO) on bone graft in a rat calvarial bone defect model under impaired osteogenic conditions. Materials and Methods:Twenty-four rats were divided into three groups. Localized radiation with a single 12 Gy dose was administered to the calvaria. Four weeks after radiation, calvarial circular defects were created in the parietal bones. All defects were filled with biphasic calcium phosphate. After the bone graft, PTH [1-34] was injected subcutaneously, and HBO was administered. At 6 weeks after the bone graft, the rats were sacrificed, and specimens were harvested.Results: Histomorphometric evaluation showed that the percentage of new bone area was higher in the PTH and PTH/HBO groups than in the control group. The percent residual material area was decreased in the PTH/HBO group compared with the control group. The percentage blood vessel number was highest in the PTH group. Micro-CT evaluation showed that the new bone volume was highest in the PTH/HBO group. The residual material volume was lowest in the PTH/HBO group. Conclusion:Within the limitations of this study, our data indicate that PTH combined with HBO may reverse radiation-induced impairment of bone healing. K E Y W O R D Sanimal model, bone graft, bone regeneration, calvarial defect, hyperbaric oxygen therapy, parathyroid hormone

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Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits

Cited by 4 publications

References 39 publications

Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

In vivo hydroxyapatite scaffold performance in infected bone defects

Synergistic effect of hyperbaric oxygen therapy with PTH [1–34] on calvarial bone graft in irradiated rat

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