Parathyroid hormone and calcitonin levels in vitamin D deficient rickets

Zamboni, Giorgio; Cecchettin, M; Albertini, Alberto; Andreoli, A.; Zoppi, G

doi:10.1007/bf00442350

Cited by 5 publications

(4 citation statements)

References 25 publications

(20 reference statements)

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“…Similarly, trace elements appear to be decreased as previously described in adults (27,28). But, as in the case of adults, a prolonged period of such diet would be necessary to determine the effect of fiber on the serum values of the trace elements.…”

Section: Resultssupporting

confidence: 82%

Potential Complications in the Use of Wheat Bran for Constipation in Infancy

Zoppi,

Gobio‐Casali,

Deganello

et al. 1982

J. pediatr. gastroenterol. nutr.

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SummaryA commercially available wheat bran preparation has been given to six infants between the ages of 6 and 16 months suffering from constipation not due to metabolic or anatomic causes. In all infants, normal bowel movements reappeared after a month of a diet containing bran. After a month on this diet, we observed the following: a decrease in blood levels of calcium, phosphate, and trace elements; an increase in fecal excretion of biliary salts and cholesterol; and an appearance of predominantly proteolytic fecal flora over the saccharolitic flora. These findings, especially the first one, indicate that bran preparations should be used in infancy with extreme caution because of possible side effects on the patient's nutritional status and growth. If bran is used, blood levels of minerals should be repeatedly checked in order to prevent the appearance of vitamin D‐dependent rickets and the depletion of trace elements.

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Section: Resultssupporting

confidence: 82%

Potential Complications in the Use of Wheat Bran for Constipation in Infancy

Zoppi,

Gobio‐Casali,

Deganello

et al. 1982

J. pediatr. gastroenterol. nutr.

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“…However the thalassaemic patients ingesting vitamin D supplement had normal 25OHD3 levels [8]. In our patients there was no historic evidence of low sunlight exposure, but they had never taken vitamin D supplements or therapy, and this may explain the decrease in 25OHD3 levels which contribute to mineralization defects producing rickety bone changes, testified, also in thalassaemic children of group 1, by the significant increase in serum A1-P and in urinary excretion of OH-P, as occurs in vitamin D-deficient rickets [13,25]. A1-P is in fact an enzyme linked to bone mineralization [20] and OH-P is an important indicator of the catabolism of collagen [17].…”

Section: Discussionmentioning

confidence: 55%

“…In thalassaemics of group 1 serum PTH levels were slightly higher than in controls, while in conditions of vitamin D deficiency [13,25] they are much higher; but parathyroid secretion probably begins to be compromised already at this age. With increasing age, in fact, the thalassaemic children showed low serum PTH levels.…”

Section: Discussionmentioning

confidence: 84%

Parathyroid hormone, calcitonin and vitamin D metabolites in beta-thalassaemia major

Zamboni¹,

Marradi²,

Tagliaro³

et al. 1986

Eur J Pediatr

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Serum calcium (Ca), phosphorus (P), alkaline phosphatase (Al-P), parathyroid hormone (PTH), calcitonin (CT), 25-hydroxyvitamin D3 (25OHD3), 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) levels and urinary excretion of Ca, P, hydroxyproline (OH-P) and cyclic AMP (cAMP) were determined in summer and in winter in 13 thalassaemic children (7 aged 3-5 years-group 1-; and 6 aged 10-13 years-group 2-), who had never taken vitamin D supplements or therapy, and in two groups of 14 controls of the same age. In thalassaemics of group 1 only serum Al-P levels and OH-P urinary excretion were higher than in controls (P less than 0.01). In thalassaemics of group 2 Ca (P less than 0.05), P (P less than 0.05), PTH (P less than 0.001), CT (P less than 0.001), 25OHD3 (P less than 0.05), 1,25(OH)2D3 (P less than 0.001) levels and cAMP urinary excretion (P less than 0.001) were lower, whereas Al-P (P less than 0.001) and CT (P less than 0.001) levels and urinary excretion of P (P less than 0.05) and of OH-P (P less than 0.001) were higher than in controls, both in summer and in winter. Advancing age induces in thalassaemic patients a decrease in PTH secretion and a consequent deficit in synthesis of 1,25(OH)2D3 that may explain some aspects of bone changes, which CT hypersecretion may tend to counteract.

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“…Urinary HyPRO reflects bone collagen turnover (10) and is considered as an index of the metabolic activity of this collagen in various physiological conditions. Thus, changes in tlyPRO excretion were observed in patients with vitamin D deficient rickets (11,12)as well as in vRamin D deficient animals (13,14,15) ;the urinary GAG Send offprint requests to Y. Dupuis at the above address. …”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D deficiency on urinary excretion of connective tissue derivatives (hydroxyproline and glycosaminoglycans) in rats

Dupuis

Gaudin-Harding

1981

Calcif Tissue Int

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The urinary excretion of two connective tissue metabolites was studied in both control and vitamin D deficient rats. Hydroxyproline (HyPRO) excretion was determined after 2, 13 and 22 months (experiment I). It decreased with aging in animals receiving the control diet. On the contrary, this excretion increased as a function of age in vitamin D deficient animals. At the age of 22 months, HyPRO excretion was respectively 31 and 1708 micrograms a day in control and deficient animals. HyPRO and glycosaminoglycans (GAG) excretion was measured on a group of both control and vitamin D deficient rats at the age of 21 months (experiment II). These results confirm the high excretion of HyPRO in deficient animals. On the contrary, the GAG excretion was higher in control animals than in deficient ones, the mean excretion being respectively 412 and 234 micrograms a day.

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Parathyroid hormone and calcitonin levels in vitamin D deficient rickets

Cited by 5 publications

References 25 publications

Potential Complications in the Use of Wheat Bran for Constipation in Infancy

Potential Complications in the Use of Wheat Bran for Constipation in Infancy

Parathyroid hormone, calcitonin and vitamin D metabolites in beta-thalassaemia major

Effect of vitamin D deficiency on urinary excretion of connective tissue derivatives (hydroxyproline and glycosaminoglycans) in rats

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