Parathyroid hormone in pediatric patients with β-thalassemia major and its relation to bone mineral density; a case control study

El-Nashar, Mostafa; Mortagy, Ahmed K.; El-Beblawy, Nagham M. S.; El-Gohary, Eman; Kamel, Irene Mokhtar; Rashad, Mona M.; Mouharam, W A

doi:10.1016/j.ejmhg.2016.03.004

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…Patients with thalassemia are subject to various complications such as impairment of development, endocrinopathies, and metabolic derangements. Proper circulation of vitamin D is crucial for ideal skeletal health and reduces the danger of fracture [6]. In the present study regarding weight, height, and body mass index (BMI), they were significantly lower in the thalassemic group.…”

Section: Discussionmentioning

confidence: 49%

“…Thalassemic patients have numerous bone illnesses, including bone deformities, bone pain, rickets, scoliosis, pathological fractures, osteopenia, and osteoporosis [5]. The etiology of thalassemia-associated bone diseases is complex multifactorial including hormonal deficiency, owing in particular to hypogonadism and hypoparathyroidism secondary to hemosiderosis, marrow expansion, iron overload, and desferrioxamine toxicity, that affect bone metabolism seriously [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

Abdelmotaleb

Behairy

Azim

et al. 2021

Egypt Pediatric Association Gaz

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Background Beta-thalassemia major patients are at increased risk of complications including endocrinopathies and bone disease due to iron overload. So, this study aimed to assess the growth parameters, serum levels of 25-OH-vitamin D, calcium, and phosphorous in children with beta-thalassemia major. This was a case-control study that included 55 children with beta-thalassemia major compared with 30 sex- and age-matched healthy children that served as a control group. All enrolled children were subjected to full history taking, clinical examination including anthropometric measurements, and laboratory investigations including complete blood count, serum ferritin, levels of serum calcium, phosphorus, and 25-OH-vitamin D. Results Body mass index was statistically significantly lower in the thalassemic group (P < 0.001). It was observed that vitamin D levels were significantly lower in thalassemic patients than in controls (P value < .0001). The mean serum 25-OH-vitamin D levels were 19.84 ± 5.79 ng/ml and 44.98 ± 5.77 ng/ml, respectively; 22 cases (40%) had insufficient vitamin D, and 5 cases (9%) had deficient vitamin D. Regarding serum calcium and phosphorous, there was no significant difference between the thalassemic and control groups. Conclusion Children with beta-thalassemia major had low body mass index and metabolic abnormality in the form of lower serum levels of vitamin D that signify the importance of therapeutic interventions.

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

Abdelmotaleb

Behairy

Azim

et al. 2021

Egypt Pediatric Association Gaz

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“…Similarly, hypocalcemia was seen more in thalassemic patients below 08 years of age. [6,7,8,9]. The present study found 39 cases to have hypophosphatemia which account for 38.61%, which may be due to renal function derangements and abnormality of bone marrow turnover [10,11].…”

Section: Discussionmentioning

confidence: 46%

Clinico-pathological profile of paediatric patients with thalassemia major

Sharma

Tikkas

Uikey

et al. 2020

IJPR

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Background:The average prevalence of beta-thalassemia major is 3-4% which translates to 35-45 million carriers. Repeated use of blood transfusion in these patients causes significant morbidity and associated adverse effects. Aims and Objective: To study the clinical profile and laboratory parameters of Thalassemia major patients between the age group 1-14 years. . This included history, anthropometry, clinical examinations (general and systemic examinations) and laboratory Investigations including serum ferritin. RESULT: result showed that 42% patients were found to be underweight, 26.73% were short stature, 31.68% were hypocalcemic, 44.5% had low serum alkaline phosphatase. Transfusion frequency and serum ferritin were less in 1-5 years. A significant correlation was observed between the size of the spleen and the level of ferritin. CONCLUSION: Hereby it can be concluded that early diagnosis of the disease and early institution of chelation therapy can improve the life expectancy of the Beta-thalassemia patients.So, all these children require regular monitoring of endocrine functions after 5 years of age, and regular monitoring of height, weight semi-annuallyy.

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“…Several studies have found no association between serum ferritin and osteoporosis in patients with thalassemia (26,27). Ferritin is reported to be one of the earliest markers for changes in iron stores, but it is also an acute phase reactant.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of osteoporosis and osteoarthritis among Beta Thalassemia patients

Sadri¹,

Gürsoy²,

Ermurat

et al. 2023

Med Sci Discov

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Objective: This study aims to examine the clinical and radiological features of skeletal changes in patients with thalassemia and provide a comprehensive overview of osteoporosis and osteoarthritis in these patients. Materials and Methods: We conducted a retrospective analysis of patients with transfusion-dependent thalassemia, both adults and children, who received follow-up care at our thalassemia center between 2019 and 2020.. Thalassemia was diagnosed via hemoglobin electrophoresis. Transfusion-dependent patients were defined as those who received transfusions every 2-4 weeks, while the control group consisted of individuals with thalassemia trait/carriers.. Both groups were analyzed for clinical characteristics, and Dual-energy X-ray absorptiometry (DEXA) scans, and radiographic images of the knee and wrist were evaluated. Results: DEXA scans of the femur and lumbar spine showed that the prevalence of osteoporosis , Synovial hypertrophy of the wrist joint , wrist effusion , knee effusion, and Power Doppler signals on wrist ultrasound scans was statistically significantly higher in transfusion-dependent thalassemia compared to patients with thalassemia carriers. Conclusion: Beta thalassemia is an inherited multisystem disease that leads to various musculoskeletal abnormalities. Knowledge of the musculoskeletal manifestations of thalassemia allows clinicians to guide their treatment. Familiarity with the radiological features of beta thalassemia is crucial for physicians in the timely diagnosis and management of thalassemia and its complications

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Parathyroid hormone in pediatric patients with β-thalassemia major and its relation to bone mineral density; a case control study

Cited by 8 publications

References 11 publications

Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

Clinico-pathological profile of paediatric patients with thalassemia major

Prevalence and risk factors of osteoporosis and osteoarthritis among Beta Thalassemia patients

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