Parathyroid hormone is associated with prostate cancer

Abstract

Background The present study investigated the association of serum parathyroid hormone (PTH), vitamin D, and calcium levels with prostate cancer (CaP). Methods The study population consisted of an experimental group [459 patients including 216 patients with CaP and 243 patients with benign prostate hyperplasia (BPH)] and a prostatectomy group (47 patients who underwent radical prostatectomy). Patients with serum creatinine levels >1.4 mg/dl, parathyroid disease, and/or PTH levels <10 pg/ml were excluded. Patients with CaP and patients with BPH were compared, and the correlation between serum parameters and clinical data was determined. Preoperative and postoperative PTH levels were compared in the prostatectomy group. Results Mean PTH levels were 41.67 ± 28.82 and 27.06 ± 17.32 pg/ml in the CaP and BPH groups, respectively ( p < 0.001). When patients were divided into two groups as per prostate-specific antigen levels (≤20 or >20 ng/ml), Gleason score (≤7 or ≥8), and stage (≤T3 or ≥ T4), there was no significant difference in PTH levels between the two groups. Mean postoperative PTH levels (26.93 ± 13.58 pg/ml) were significantly lower than preoperative PTH levels (36.71 ± 21.04 pg/ml) in the same patients who underwent radical prostatectomy. Conclusion Serum PTH levels were higher in patients with CaP than in patients with BPH and decreased significantly after radical prostatectomy. The present results suggest an association between serum PTH and CaP. Further large cohort studies are necessary to validate the present data.

Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years

“…The concentration of serum ionized Ca (the biologically active fraction total Ca, representing about 50% of the total amount) is tightly regulated by parathyroid hormone (PTH) and usually does not deviate by more than 2% from its stabilized value. In our study the values of total Ca have not been adjusted to the albumin level, since all patients had normal levels of serum albumin, and in nonmalnourished patients, total serum Calcium has a good correlation to PTH [15] et al [16] has proven that in prostate cancer the levels of PTH are higher than the levels in matched controls.…”

Obesity and Cancer: Potential Mediation by Dysregulated Dietary Phosphate

“…Patients with high levels of FGF23, which regulates Pi metabolism, had reduced overall survival compared to patients with low levels [28], and FGF23 levels were significantly higher in patients with urothelial carcinoma of the bladder and upper urinary tract compared to normal controls [29]. Additionally, compared to men with benign prostate hyperplasia, men with prostate cancer had higher levels of PTH, which also regulates Pi metabolism [30].…”