Parathyroid hormone is associated with decreased fat mass in young healthy women

Gunther, Carolyn; Legowski, Pamela A; Lyle, Roseann M.; Weaver, Connie M.; McCabe, Linda D; McCabe, George P.; Peacock, Munro; Teegarden, Dorothy

doi:10.1038/sj.ijo.0803066

Cited by 24 publications

(16 citation statements)

References 33 publications

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“…However, we did not observe any independent effects of calcium on body fat in the current study, which is consistent with others (Gunther et al, 2006, Lin, Lyle, McCabe, McCabe, Weaver & Teegarden, 2000, Weaver et al, 2011). Our results imply a potential role for calcium on the effects of CLA on body fat reduction.…”

Section: Discussionsupporting

confidence: 93%

Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice

et al. 2013

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Osteoporosis is a significant health concern for the elderly; conjugated linoleic acid (CLA) has been shown to improve overall bone mass when calcium is included as a co-supplement. However, potential effects of CLA and calcium on bone mass during a period of bone loss have not been reported. The purpose of this study was to determine how dietary calcium modulates the effects of conjugated linoleic acid (CLA) in preventing bone loss, using an ovariectomised mouse model. CLA supplementation significantly prevented ovariectomy-associated weight and fat mass gain, compared to non-supplemented controls. CLA significantly increased bone markers without major changes in bone mineral composition in the femur compared to respective controls. CLA treatment increased serum parathyroid hormone (PTH) significantly (p = 0.0172), while serum 1,25-dihydroxyvitamin D3 concentration was not changed by CLA. Meanwhile, CLA significantly reduced femur tartrate resistant acid phosphatase (TRAP) activity, suggesting potential reduction of osteoclastogenesis. The data suggest that CLA, along with dietary calcium, has great potential to be used to prevent bone loss and weight gain associated with menopause.

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Section: Discussionsupporting

confidence: 93%

Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice

et al. 2013

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“…Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9).…”

Section: European Journal Of Endocrinology 157 225-232mentioning

confidence: 99%

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Reinehr¹,

Sousa²,

Alexy³

et al. 2007

eur j endocrinol

181

114

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Objective: The roles of vitamin D and parathyroid hormone (PTH) are discussed controversially in obesity, and studies of these hormones in obese children are limited. Therefore, we studied the relationships between PTH, 1,25-dihydroxy-vitamin D (1,25-OH Vit D), 25-hydroxy-vitamin D (25-OH Vit D), weight status, and insulin sensitivity before and after weight loss in obese children. Methods: Fasting serum PTH, 1,25-OH Vit D, 25-OH Vit D, inorganic phosphate, calcium, alkaline phosphatase (AP), insulin, glucose, and weight status (SDS-BMI and percentage body fat) were determined in 133 obese children (median age 12.1 years) and compared with 23 non-obese children. Furthermore, these parameters were analyzed in 67 obese children before and after participating in a 1-year obesity intervention program. Results: Obese children had significantly (P!0.001) higher PTH and lower 25-OH Vit D concentrations compared with non-obese children, while calcium, phosphate, AP, and 1,25-OH Vit D did not differ significantly. Changes of PTH (rZ0.23, PZ0.031) and 25-OH Vit D (rZK0.27, PZ0.013) correlated significantly with changes of SDS-BMI, but not with changes of insulin sensitivity (homeostasis model assessment; HOMA-B%). Reduction of overweight in 35 children led to a significant (P!0.01) decrease of PTH concentrations and an increase in 25-OH Vit D levels. Conclusions: PTH levels were positively and 25-OH Vit D concentrations were negatively related to weight status. Since these alterations normalized after weight loss, these changes are consequences rather than causes of overweight. A relationship between PTH, vitamin D, and insulin sensitivity based on the HOMA index was not found in obese children. Further longitudinal clamp studies are neccessary to study the relationship between vitamin D and insulin sensitivity. European Journal of Endocrinology 157 225-232Introduction Vitamin D and parathyroid hormone (PTH) are well known for their essential role in bone metabolism and calcium homeostasis. The main sources of vitamin D are ergocalciferol and cholecalciferol, the former normally available in food and the latter produced in the skin by u.v. radiation of 7-dehydrocholesterol. Both of these compounds are hydroxylated in the liver to 25-hydroxyvitamin D (25-OH Vit D), which is the major circulating metabolite precursor to the hormonally active form, 1,25-dihydroxy-vitamin D (1,25-OH Vit D).It has become increasingly clear that the vitamin D endocrine system is related to obesity in adults. Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9). PTH has been postulated as an independent predictor of obesity (7). Overweight as a consequence of elevated serum PTH was explained by several mechanisms (10, 11): PTH stimulates the renal hydroxylation of 25-OH Vit D to its active form, 1,25-OH Vit D, which in turn elevates the calcium influx into adipocytes. In these cell...

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“…[1][2][3][4][5][6][7][8][9][10] Although this association has been attributed to increased storage of 25(OH)D in fat tissue or potential lifestyle differences between obese and nonobese populations, 11,12 evidence from epidemiologic, [1][2][3][4][5][6][7][8][9][10] weight loss, [13][14][15][16][17] and in vitro/ animal studies [18][19][20][21][22][23][24] suggests that 25(OH)D might be involved in weight regulation. Vitamin D receptors (VDR) are present on human adipocytes.…”

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confidence: 99%

Associations Between 25-Hydroxyvitamin D and Weight Gain in Elderly Women

LeBlanc

Rizzo

Pedula

et al. 2012

Journal of Women's Health

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Results: Women with 25(OH)D levels ‡ 30 ng/mL had lower baseline weight (141.6 pounds) compared to women with 25(OH)D levels < 30 ng/mL (148.6 pounds) ( p < 0.001). Overall, 25(OH)D status was not associated with weight change over 4.5 years, although there was a significant interaction between 25(OH)D status and weight change category (loss, gain, stable) ( p < 0.0001). In women who gained ‡ 5% weight, those with baseline 25(OH)D levels ‡ 30 ng/mL gained 16.4 pounds (12.2% of baseline weight) over 4.5 years compared to 18.5 pounds (13.9% of baseline weight) in women with levels < 30 ng/mL ( p = 0.04). In women who lost ‡ 5% weight or remained stable ( < 5% weight change), there was no association between 25(OH)D status at baseline and weight change. Among women who gained weight and had 25(OH)D measured at both visits, having sustained or developing 25(OH)D levels ‡ 30 ng/mL was associated with less weight gain between visits (14.81 vs. 16.34 pounds, p = 0.04). Conclusions: Higher 25(OH)D levels are associated with lower weight gains, suggesting low vitamin D status may predispose to fat accumulation.

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Parathyroid hormone is associated with decreased fat mass in young healthy women

Cited by 24 publications

References 33 publications

Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice

Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Associations Between 25-Hydroxyvitamin D and Weight Gain in Elderly Women

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