Parathyroid Hormone‐Loaded Microneedle Promotes Tendon Healing Through Activation of mTOR

Yao, Zhewei; Xue, Tong; Cai, Chuandong; Li, Juehong; Lu, Mingkuan; Li, Xudong; Jin, Tao; Wu, Fei; Liu, Shen; Fan, Cunyi

doi:10.1002/adtp.202000025

Cited by 10 publications

(3 citation statements)

References 59 publications

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“…This enabled sustained release of parathyroid hormone for 24 h in mice in vivo. [ 63 ] Using a similar strategy, a group utilized PVA based MNAs containing a long‐acting PVP/PEG‐based NPs loaded with rilpivirine (RPV), to provide a more acceptable choice for treatment of HIV. Based on the results of in vivo studies the MNAs could maintain effective RPV plasma levels over 7 d in humans.…”

Section: Mnas Enable Controlled‐release Mechanismsmentioning

confidence: 99%

Exploiting Unique Features of Microneedles to Modulate Immunity

et al. 2023

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Microneedle arrays (MNAs) are small patches containing hundreds of short projections that deliver signals directly to dermal layers without causing pain. These technologies are of special interest for immunotherapy and vaccine delivery because they directly target immune cells concentrated in the skin. The targeting abilities of MNAs result in efficient immune responses—often more protective or therapeutic—compared to conventional needle delivery. MNAs also offer logistical benefits, such as self‐administration and transportation without refrigeration. Thus, numerous preclinical and clinical studies are exploring these technologies. Here we discuss the unique advantages of MNA, as well as critical challenges – such as manufacturing and sterility issues – the field faces to enable widespread deployment. We explain how MNA design parameters can be exploited for controlled release of vaccines and immunotherapies, and the application to preclinical models of infection, cancer, autoimmunity, and allergies. We also discuss specific strategies to reduce off‐target effects compared to conventional vaccine delivery routes, and novel chemical and manufacturing controls that enable cargo stability in MNAs across flexible intervals and temperatures. We then examine clinical research using MNAs. We conclude with drawbacks of MNAs and the implications, and emerging opportunities to exploit MNAs for immune engineering and clinical use.This article is protected by copyright. All rights reserved

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Section: Mnas Enable Controlled‐release Mechanismsmentioning

confidence: 99%

Exploiting Unique Features of Microneedles to Modulate Immunity

et al. 2023

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“…For example, PVA, a swellable polymer, was used to fabricate MNAs. This enabled sustained release of parathyroid hormone for 24h in mice in vivo 63 . Using a similar strategy, a group utilized PVA based MNAs containing a long-acting PVP/PEG based NPs loaded with rilpivirine (RPV), to provide a more acceptable choice for treatment of HIV.…”

Section: Mnas Enable Sustained Release Of Cargomentioning

confidence: 99%

Exploiting Unique Features of Microneedles to Modulate Immunity

Edwards,

Shah,

Gebhardt

et al. 2024

Advanced Materials

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“…[46] Based on this, Yao et al developed hydrogel microneedles with PVA needles containing parathyroid hormone (PTH). [48] PTH is a systemic hormone exhibiting a positive impact on tendon bone healing process. [49,50] The PVA-based hydrogel microneedles were fabricated using the freezing-thawing method, [51] keeping PTH from denaturing.…”

Section:  Repairing Defective Connective Tissuesmentioning

confidence: 99%

Microneedle system for tissue engineering and regenerative medicine

Zhang

Kong

et al. 2023

Exploration

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Global increasing demand for high life quality and length facilitates the development of tissue engineering and regenerative medicine, which apply multidisciplinary theories and techniques to achieve the structural reconstruction and functional recovery of disordered or damaged tissues and organs. However, the clinical performances of adopted drugs, materials, and powerful cells in the laboratory are inescapably limited by the currently available technologies. To tackle the problems, versatile microneedles are developed as the new platform for local delivery of diverse cargos with minimal invasion. The efficient delivery, as well as painless and convenient procedure endow microneedles with good patient compliance in clinic. In this review, we first categorize different microneedle systems and delivery models, and then summarize their applications in tissue engineering and regenerative medicine mainly involving maintenance and rehabilitation of damaged tissues and organs. In the end, we discuss the advantages, challenges, and prospects of microneedles in depth for future clinical translations.

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Parathyroid Hormone‐Loaded Microneedle Promotes Tendon Healing Through Activation of mTOR

Cited by 10 publications

References 59 publications

Exploiting Unique Features of Microneedles to Modulate Immunity

Exploiting Unique Features of Microneedles to Modulate Immunity

Exploiting Unique Features of Microneedles to Modulate Immunity

Microneedle system for tissue engineering and regenerative medicine

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