Parathyroid hormone (PTH)-related protein, PTH, and 1,25-dihydroxyvitamin D in dogs with cancer-associated hypercalcemia.

Rosol, Thomas J.; Nagode, Larry A.; Couto, C. Guillermo; Hammer, Alan S.; Chew, Dennis J.; Peterson, Janet L.; Ayl, Rodney; Steinmeyer, C.L.; Capen, Charles C.

doi:10.1210/endo.131.3.1505457

Cited by 58 publications

(23 citation statements)

References 19 publications

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“…14,15 This protein behaves in a biologically similar way to parathyroid hormone, increasing the serum calcium concentration. Rosol et al 15 detected that canine CAS cells produce PTHrP and that a significant linear correlation exists between circulating PTHrP and serum calcium concentrations in dogs with CAS.…”

Section: Discussionmentioning

confidence: 99%

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Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985–1995)

Williams¹,

Gliatto²,

Dodge³

et al. 2003

javma

131

218

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Section: Discussionmentioning

confidence: 99%

“…6, September15, 2003 Scientific Reports: Retrospective Study 827SMALL ANIMALSTable 1-Clinical signs at initial evaluation in 113 dogs with carcinoma of the anal sac…”

mentioning

confidence: 99%

Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985–1995)

Williams¹,

Gliatto²,

Dodge³

et al. 2003

javma

131

218

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“…Polydipsia, polyuria, and hypercalcemia have been reported to be due to parathyroid hormone-related polypeptide produced by the tumor cells. [6][7][8][9] This results in pseudohyperparathyroidism or hypercalcemia of malignancy, the most common cause of hypercalcemia in the dog. 10 In the study of 32 dogs with ASAC, hypercalcemia was present in 8 dogs, only 5 of which had polydipsia and polyuria.…”

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confidence: 99%

Canine Anal Sac Adenocarcinomas: Clinical Presentation and Response to Therapy

et al. 2002

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A retrospective study of 43 dogs with anal sac adenocarcinoma (ASAC) was performed to characterize the clinical presentation and response to treatment. Clinical signs at presentation varied considerably, with signs related either to sublumbar nodal metastasis (tenesmus or constipation) or hypercalcemia (polyuria-polydipsia and anorexia) being the most frequent findings. At the time of presentation, 23 (53%) dogs had hypercalcemia and 34 (79%) had metastases, with the regional lymph nodes (31 dogs, 72%) being the most common site of metastasis. A variety of chemotherapeutic agents were administered, with partial remission (PR) recorded in 4 of 13 (31%) dogs treated with cisplatin and in 1 of 3 (33%) dogs treated with carboplatin. The median survival for all dogs was 6 months (range, 2 days-41 months). There was no statistical association between the presence of hypercalcemia and survival, although the power of the study to detect an increase in survival of 3 months was low (.33). We conclude that platinum chemotherapy has antitumor activity in canine apocrine gland carcinoma and that further study of these agents is warranted.Key words: Anal tumors; Chemotherapy; Dog; Surgery.A nal sac disease in the dog is common and affects approximately 12% of the canine population. 1 The majority of anal sac disease consists of impactions and infections, 1 with neoplasia being an uncommon occurrence. 2 Tumors in the perineal area, however, are common in the dog, with the majority being adenomas of the perianal glands. 3 Perianal adenomas are seen most frequently in intact male dogs because of the tumor's testosterone dependence. 3 The most common malignancy in the perineal area in older female dogs is anal sac adenocarcinoma (ASAC). These tumors arise from the apocrine glands of the anal sac. 3 ASAC accounts for approximately 2% of skin tumors in the dog. 2 ASACs are malignant neoplasms with a propensity to metastasize initially to the regional lymph nodes, and then to the liver, spleen, lungs, and other sites. 4,5 Reports of ASAC are limited in the veterinary literature. [2][3][4][5] There is some conflicting information regarding gender predisposition. In 2 reports, 11 of 14 4 and 30 of 32 5 dogs with ASAC were female. A large study of 238 dogs, however, suggested a similar occurrence in males and females, with 56% being female. 2 ASAC is a disease of older dogs, with the mean age at presentation reported to be 10.2-10.8 years, having a range of 3-17 years. [2][3][4][5] There is limited information on breed predisposition. German Shepherds accounted for 3 of 14 4 and 4 of 32 5 patients in 2 small studies. In the larger report of 238 dogs, several breeds including the English Cocker Spaniel, Dachshund, Alaskan Malamute, English Springer Spaniel, and German Shepherd were reported to be at increased risk of developing ASAC. 2

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“…In some cases, 1, 25-dihydroxyvitamin D may contribute to hypercalcemia of malignancy associated with lymphosarcoma. 74 Multicentric and thymic (cranial mediastinal) forms of lymphosarcoma are most commonly associated with hypercalcemia. About 10% of dogs with multicentric lymphosarcoma and half of dogs with thymic forms develop hypercalcemia.…”

Section: Hypercalcemia Of Malignancymentioning

confidence: 99%