Parathyroid hormone secretion: Effect of estradiol and progesterone

Greenberg, Cyrus M.; Kukreja, Subhash C.; Bowser, E. N.; Hargis, G. K.; Henderson, W. J.; Williams, George C.

doi:10.1016/0026-0495(87)90009-6

Cited by 51 publications

(17 citation statements)

References 10 publications

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“…The action of estradiol to increase the expression of the PTH and calcitonin genes, and the presence ofthe estrogen receptor mRNA and protein in the parathyroid and C cells, as shown in this study, together with the earlier reports of a direct effect of estrogens to increase PTH and calcitonin secretion (16)(17)(18)(19) establish that these two organs are target organs for estrogens.…”

Section: Discussionsupporting

confidence: 86%

“…Our results, together with the earlier in vitro reports of a direct effect of estrogens on PTH and calcitonin secretion (16)(17)(18)(19), indicate that the effect of estrogens to increase PTH and calcitonin levels is a direct effect ofestrogens on the parathyroid and C cells, respectively. In addition we have preliminary data with bovine parathyroid cells in primary culture, and a calcitonin producing cell line, that estrogens in vitro increase PTH and calcitonin mRNA levels, respectively (Naveh-Many, T., and J.…”

Section: Discussionsupporting

confidence: 85%

“…Estrogens might also have an indirect effect on bone by regulating the production of the calcium regulating hormones. In vitro studies have shown that estrogens increase the secretion of PTH from both bovine and human parathyroid tissue, and increase the secretion ofcalcitonin from a medullary carcinoma cell line (16)(17)(18)(19). We have now studied the regulation of PTH and calcitonin gene expression in vivo in the rat, and the presence ofthe estrogen receptor mRNA and protein in the rat parathyroid and C cells.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen receptors and biologic response in rat parathyroid tissue and C cells.

Naveh-Many¹,

Almogi²,

Livni³

et al. 1992

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estrogen receptors and biologic response in rat parathyroid tissue and C cells.

Naveh-Many¹,

Almogi²,

Livni³

et al. 1992

J. Clin. Invest.

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“…This might reflect a decreased metabolic and renal clearance of PTH since in rats, glomerular filtration rate decreases with increasing age [30]. In vitro studies have shown that estrogens increase the secretion of PTH from both bovine and human parathyroid tissue [31,32]. The in vivo studies carried out in young female rats demonstrate that a single injection of 37-145 nmol E 2 leads a fourfold increase in PTH mRNA [22].…”

Section: Discussionmentioning

confidence: 93%

Influence of ovariectomy on bone metabolism in very old rats

Gaumet¹,

Seibel

Braillon

et al. 1996

Calcif Tissue Int

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Twenty-five 30-month-old Lou rats fed a diet (6 g/100 g BW/day) containing 0.9% Ca and 0.8% Pi were divided into five groups. Four groups were surgically ovariectomized. From day 2 until day 29 after ovariectomy, they were S.C. injected either with 17 beta estradiol (E2; 10 micrograms/kg BW/48 hours) or progesterone (P; 140 micrograms/kg BW/48 hours), or 17 beta estradiol + progesterone (E2P) at the same doses, or solvent alone (OVX). The fifth group was sham operated (SH) and injected with solvent. Urine was collected in metabolic cages from day 24 to 29 after ovx, and urinary pyridinoline (PYD) and deoxypyridinoline (DPD) excretion (markers of bone resorption) was measured by HPLC. All animals were killed 30 days after ovariectomy. Serum was then collected for measurement of osteocalcin (OC), alkaline phosphatase (ALP), parathyroid hormone (PTH), and calcitonin (CT). At necropsy, the success of ovariectomy was checked by marked atrophy of the uterine horns. Left and right femur were harvested for densitometric and mineral analysis, respectively. Ovariectomy had no significant effect upon plasma calcium and PTH concentrations. E2 or E2P treatment significantly increased plasma PTH and calcitonin concentrations. Plasma OC concentrations and ALP were not different in any of the groups. In contrast, urinary excretion of PYD and DPD was higher in OVX than in SH rats. Bone mineral density (BMD) of the distal femur was decreased by OVX, but was not different in the E2P and SH groups. A similar pattern was observed for the mineral or Ca content of whole femur. Thus, OVX decreased BMD and bone mineral content (BMC) in very old female rats. Plasma OC concentration and ALP activity failed to demonstrate any significant effect of OVX, whereas PYD and DPD were elevated. These results suggest that bone resorption is increased in OVX rats, even when supplemented with E2 or P alone. However, no significant difference was observed between SH and OVX rats treated with supplementation of both E2 and P. Thus, in very old rats, a combination of E2 and P is much more effective than E2 or P alone to prevent bone loss following ovariectomy.

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“…Greenberg et al [11] showed a direct stimulatory effect of estrogen on PTH secretion, and Gallagher et al [7] proposed that a decreased calcium concentrations during estrogen administration stimulate PTH secretion, which in turn stimulates the release of 1,25-(OH)2D and increases calcium absorption.…”

Section: Discussionmentioning

confidence: 99%