Paraventricular nucleus‐central amygdala oxytocinergic projection modulates pain‐related anxiety‐like behaviors in mice

Li, Y; Du, Weijia; Li, Rui; Zan, Gui-Ying; Ye, Binglu; Li, Qian; Sheng, Zhihao; Yang, Yuan; Song, Yujie; Liu, Jing-Gen; Liu, Zhiqiang

doi:10.1111/cns.14282

Cited by 11 publications

(6 citation statements)

References 33 publications

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“…Intriguingly, HCN channels' inhibition had no effects on SNI‐induced anxiety‐like behaviors. We speculated that HCN channels in the LHb serve a crucial role in regulating depressive‐like behaviors, while anxiety‐like behaviors in SNI 6w mice might be associated with other neural mechanisms in the LHb or related to other brain regions, such as the amygdala, 56 , 57 , 58 , 59 hippocampus, 60 and prefrontal cortex. 61 , 62 Further investigations were required to confirm these speculations.…”

Section: Discussionmentioning

confidence: 99%

HCN channels in the lateral habenula regulate pain and comorbid depressive‐like behaviors in mice

Cao,

Zhu,

et al. 2024

CNS Neurosci Ther

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AimsComorbid anxiodepressive‐like symptoms (CADS) in chronic pain are closely related to the overactivation of the lateral habenula (LHb). Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels have been implicated to play a key role in regulating neuronal excitability. However, the role of HCN channels in the LHb during CADS has not yet been characterized. This study aimed to investigate the effect of HCN channels in the LHb on CADS during chronic pain.MethodsAfter chronic neuropathic pain induction by spared nerve injury (SNI), mice underwent a sucrose preference test, forced swimming test, tail suspension test, open‐field test, and elevated plus maze test to evaluate their anxiodepressive‐like behaviors. Electrophysiological recordings, immunohistochemistry, Western blotting, pharmacological experiments, and virus knockdown strategies were used to investigate the underlying mechanisms.ResultsEvident anxiodepressive‐like behaviors were observed 6w after the SNI surgery, accompanied by increased neuronal excitability, enhanced HCN channel function, and increased expression of HCN2 isoforms in the LHb. Either pharmacological inhibition or virus knockdown of HCN2 channels significantly reduced LHb neuronal excitability and ameliorated both pain and depressive‐like behaviors.ConclusionOur results indicated that the LHb neurons were hyperactive under CADS in chronic pain, and this hyperactivation possibly resulted from the enhanced function of HCN channels and up‐regulation of HCN2 isoforms.

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Section: Discussionmentioning

confidence: 99%

HCN channels in the lateral habenula regulate pain and comorbid depressive‐like behaviors in mice

Cao,

Zhu,

et al. 2024

CNS Neurosci Ther

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“…In human positron emission tomography (PET) studies, use of radioactive ligands has revealed alterations in the binding potential of μ-opioid receptors in chronic pain sufferers (e.g., Zubieta et al, 2001;Maarrawi et al, 2007;Li Y.-J. et al, 2023;.…”

Section: Opioidsmentioning

confidence: 99%

“…In animal studies, analgesic effects of oxytocin have been described after experimentally induced acute (Rash et al, 2014), neuropathic and inflammatory pain experiences (Yu et al, 2003;Condes-Lara et al, 2005;Eliava et al, 2016;Sun et al, 2018;Hilfiger et al, 2020;Li et al, 2021;Esmaeilou et al, 2022;Nishimura et al, 2022;Iwasaki et al, 2023;Krabichler and Reynders, 2023;Li Y.-J. et al, 2023;, and increased expression of oxytocin receptors has been reported after chemotherapy-induced neuropathic pain in mice (Li et al, 2023a).…”

Section: Oxytocinmentioning

confidence: 99%

“…With regard to nociception, oxytocin influences physiological activity in known pain-related sites in the brain such as PAG, prefrontal and somatosensory cortex, ACC, insula, amygdala, NAc, raphe and hypothalamus (Figure 1) (e.g., Gu and Yu, 2007;Eliava et al, 2016;Boll et al, 2018;Poisbeau et al, 2018;Li et al, 2021;Saito et al, 2021;Nishimura et al, 2022;Yang et al, 2022;Iwasaki et al, 2023;Li et al, 2023a). Receptors are also found in the spinal cord and on a proportion of peripheral sensory neurons in the dorsal root ganglia (DRG) (Condes-Lara et al, 2005;Gong et al, 2015;González-Hernández et al, 2017;Poisbeau et al, 2018;Martinez-Lorenzana et al, 2021;Noguri et al, 2022;Yang et al, 2022;Li Y.-J. et al, 2023;.…”

Section: Oxytocinmentioning

confidence: 99%

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The psychophysiology of music-based interventions and the experience of pain

Arnold,

Bagg,

Harvey

2024

Front. Psychol.

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In modern times there is increasing acceptance that music-based interventions are useful aids in the clinical treatment of a range of neurological and psychiatric conditions, including helping to reduce the perception of pain. Indeed, the belief that music, whether listening or performing, can alter human pain experiences has a long history, dating back to the ancient Greeks, and its potential healing properties have long been appreciated by indigenous cultures around the world. The subjective experience of acute or chronic pain is complex, influenced by many intersecting physiological and psychological factors, and it is therefore to be expected that the impact of music therapy on the pain experience may vary from one situation to another, and from one person to another. Where pain persists and becomes chronic, aberrant central processing is a key feature associated with the ongoing pain experience. Nonetheless, beneficial effects of exposure to music on pain relief have been reported across a wide range of acute and chronic conditions, and it has been shown to be effective in neonates, children and adults. In this comprehensive review we examine the various neurochemical, physiological and psychological factors that underpin the impact of music on the pain experience, factors that potentially operate at many levels – the periphery, spinal cord, brainstem, limbic system and multiple areas of cerebral cortex. We discuss the extent to which these factors, individually or in combination, influence how music affects both the quality and intensity of pain, noting that there remains controversy about the respective roles that diverse central and peripheral processes play in this experience. Better understanding of the mechanisms that underlie music’s impact on pain perception together with insights into central processing of pain should aid in developing more effective synergistic approaches when music therapy is combined with clinical treatments. The ubiquitous nature of music also facilitates application from the therapeutic environment into daily life, for ongoing individual and social benefit.

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“…The bursting pattern is regulated by various physiological and environmental factors, such as sensory stimuli, including touch, suckling, and sexual activity. These stimuli activate specific brain regions, leading to increased activity in oxytocin [22,30,31]…”

Section: Physiological Relevance (Bursting Behavior Etc)mentioning

confidence: 99%

Modulation of Oxytocin Release by Internal Calcium Stores

Velázquez-Marrero,

R. Lemos

2024

Oxytocin and Social Function

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This chapter elucidates the role of depolarization-induced oxytocin (OT) vs. arginine vasopressin (AVP) secretion in the absence of external calcium, and calcium release from ryanodine-sensitive internal stores as a significant physiological contributor to neuropeptide secretion from hypothalamic neurohypophysial system (HNS) terminals. This has important therapeutic implications, given that exogenous administration of OT to children with autism spectrum disorders (ASD) has shown some success in improving social behavior and lowering anxiety. However, this nonspecific treatment has side effects, including seizures, increased heart rate variability, and psychotic symptoms. Alternatively, facilitating the physiological neuronal release of OT but not AVP from the HNS via modulation of ryanodine vs. inositol triphosphate receptor (IP3R) calcium stores would specifically facilitate central vs. peripheral OT release in ASD patients.

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Paraventricular nucleus‐central amygdala oxytocinergic projection modulates pain‐related anxiety‐like behaviors in mice

Cited by 11 publications

References 33 publications

HCN channels in the lateral habenula regulate pain and comorbid depressive‐like behaviors in mice

HCN channels in the lateral habenula regulate pain and comorbid depressive‐like behaviors in mice

The psychophysiology of music-based interventions and the experience of pain

Modulation of Oxytocin Release by Internal Calcium Stores

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