Parecoxib as an Alternative in COX-2 Hypersensitivity

Abstract

The group of non-steroidal anti-inflammatory drugs (NSAIDs) is commonly involved in hypersensitivity reactions. In clinical practice the physician is often faced with the need to choose an alternative anti-inflammatory agent for a patient who has suffered a hypersensitivity reaction to a NSAID. The most common approach to choosing the safest NSAID is to perform a challenge test. Parecoxib is the first injectable COX-2 selective inhibitor indicated for the treatment of acute postoperative pain. The authors report the case of a patient with a history of cutaneous adverse reactions to different classes of NSAIDs, including selective COX-2 inhibitors, who underwent and tolerated challenge with parecoxib.

Autism and Immunity: Revisited Study

“…Findings also support the view that neuro-immune abnormalities occur in the brain of autistic patients and may contribute to the diversity of the autistic phenotypes (4). Although several lines of research support the view that this is a result of a complex combination of neurological, environmental, immunological, and genetic factors, it is widely reported that several white blood cells are important in the pathogenesis of neurological diseases (5)(6)(7)(8), and it is established in animal and human diseases such as autoimmunity, inflammation and cancer (9)(10)(11)(12)(13)(14). In addition, proinflammatory cytokines secreted by different types of cells contribute to the pathogenesis ofneuro-inflammation (12,15).…”

Inflammatory Compounds: Neuropeptide Substance Pand Cytokines

“…Substance P (SP) is a potent modulator of monocyte/macrophage function and causes transcription and translation of several different cytokines/chemokines such as tumor necrosis factoralpha (TNF-alpha), macrophage inflammatory protein-l (MIP-l) and GM-CSF, RANTES, MCp• 1, CXCL8, along with other proinflammatory compounds, proteases (chymase and tryptase), histamine, leukotrienes and prostaglandin 02 (6,(68)(69)(70).…”