Parent and nano-encapsulated ytterbium(<scp>iii</scp>) complex toward binding with biological macromolecules, <i>in vitro</i> cytotoxicity, cleavage and antimicrobial activity studies

Aramesh‐Boroujeni, Zahra; Jahani, Shohreh; Khorasani-Motlagh, Mozhgan; Kerman, Kağan; Noroozifar, Meissam

doi:10.1039/d0ra03895d

Cited by 15 publications

(6 citation statements)

References 53 publications

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“…These factors include the dipole moment, size, geology of the complex, managing spots, electron transfer capability of the metal ion, dissolvability, bond length amidst the metal and binding, steric effects, density, and hydrophobicity. Taken together, these factors collectively contribute to the overall antimicrobial activity of the complex ( Aramesh-Boroujeni et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

RETRACTED: Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies

Thanoon,

Ibadi,

Ahmad

et al. 2023

Front. Chem.

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To assess the biological potential of an Er complex that contains a 2,2'-bipyridine ligand, various techniques such as multispectral and molecular modeling procedures were utilized to examine its DNA-binding ability, BSA binding affinity, antimicrobial effects, and anticancer properties. By analyzing fluorescent information and employing the vant’ Hoff equation, important parameters such as the innate docking coefficient (Kb), Stern-Volmer coefficient (KSV), and thermodynamic properties including modifications in liberated energy (ΔG°), enthalpy (∆H°), and entropy (∆S°) were determined. The trial findings suggest that the compound can bind to DNA, primarily through groove binding. Additionally, the engagement between the Er compound and the protein BSA was examined using emission spectroscopy technique, revealing a powerful binding affinity between the compound and BSA. The Er complex binds to BSA primarily via hydrogen links and van der Waals forces, as indicated by the adverse values of ΔH° and ∆S°. Through a static quenching process, the complex significantly reduces the intrinsic fluorescence of BSA. Molecular binding calculations and rivalrous binding trials confirm that this compound dock to hydrophobic remains found in site III of BSA. Additionally, the Er complex demonstrates promising results in terms of its anticancer and antimicrobial activities based on screening tests.

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Section: Resultsmentioning

confidence: 99%

RETRACTED: Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies

Thanoon,

Ibadi,

Ahmad

et al. 2023

Front. Chem.

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“…According to the published studies, the increase in emission intensity is related to classical interactions such as intercalation interactions. Therefore, it can be concluded that the interaction of the Y-complex with DNA can be a non-classical interaction ( He et al, 2019 ; Amraoui et al, 2020 ; Aramesh-Boroujeni et al, 2020d ). By plotting log(F 0 − F)/F vs. log[DNA] and calculating its slope and intercept, the bond constant values were calculated at 295, 298, 300, and 303 K ( Figure 3B ; Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…In this case, the intensity of fluorescence quenching will decrease. Therefore, NaCl solution can be used to investigate the competition with phosphate groups ( Aramesh-Boroujeni et al, 2020a ; Aramesh-Boroujeni et al, 2020d ). The effect of ionic strength on Y-complex emission intensity is shown in Figure 6A .…”

Section: Resultsmentioning

confidence: 99%

RETRACTED: Spectroscopic and molecular modeling studies of binding interaction between the new complex of yttrium and 1,10-phenanthroline derivatives with DNA and BSA

Khorshidi,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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In this study, the 4,9 diazafluoren-9-one ligand and [Y(Daf)2Cl3.OH2] complex were synthesized. The interaction of this complex with DNA and bovine serum albumin (BSA) was investigated by UV-vis and fluorescence spectroscopy. The molecular docking method was used to confirm the experimental results, investigate the type of interaction, and determine the binding site. The binding constant and Stern–Volmer constant were calculated using spectroscopy techniques. The binding constant of the Y-complex with DNA and BSA obtained using the UV-vis technique was 1.61 × 105 M−1 and 0.49 × 105 M−1, while that obtained using the fluorescence method was 3.39 × 105 M−1 and 3.63 × 105 M−1, respectively. The results of experimental and theoretical data showed that the interaction between the yttrium complex and DNA and BSA is driven by the hydrogen bond and van der Waals interaction, respectively. The yttrium complex communicates with DNA via the groove interaction. This complex has high binding energy with bovine serum albumin. In addition, the molecular docking results showed that the complex binds to the IIA subdomain of BSA (site I). Finally, anticancer activity of the yttrium complex was studied on MCF-7 and A549 cell lines by using the MTT method. The IC50 values obtained showed that the yttrium complex possesses anticancer activity.

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“…8 Furthermore, serum albumins are the most abundant protein in blood that show signicant role in the distribution, metabolism, and transport of various exogenous compounds (containing drugs, amino acids, fatty acids, and pharmaceuticals). 10 In continuation of recent research work, [11][12][13][14][15][16][17] the synthesis, characterization, and interaction of the Sm-complex, [Sm(bpy) 2 Cl 3 (OH 2 )] (Scheme 1), with FS-DNA and BSA by different types of experimental techniques and docking calculation are reported in this paper. Moreover, the parent, lipid nano-encapsulated (LNEP) and starch nano-encapsulated Scheme 1 Chemical structure of the Sm-complex.…”

Section: Introductionmentioning

confidence: 93%

In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

2020

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Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

Abstract: The biological applications of Yb-complexes including anticancer, antimicrobial and DNA cleavage ability, and their interaction with FS-DNA and BSA were examined.

Cited by 15 publications

References 53 publications

RETRACTED: Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies

RETRACTED: Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies

RETRACTED: Spectroscopic and molecular modeling studies of binding interaction between the new complex of yttrium and 1,10-phenanthroline derivatives with DNA and BSA

In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

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