Parent-child separation and cardiometabolic outcomes and risk factors in adulthood: A systematic review

Tang, Alva; Ertel, Karen A.; Keen, Ryan; Beyer, Logan; Eckert, Natalie; Mita, Carol; Pintro, Kedie; Okuzono, Sakurako S.; Yazawa, Aki; Slopen, Natalie

doi:10.1016/j.psyneuen.2023.106084

Cited by 5 publications

(4 citation statements)

References 50 publications

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“…The search of electronic databases revealed 1 published study matching our inclusion criteria, 21 while another was published by collaborators during the preparation of this manuscript 22 (Figure 1). Additionally, we identified eleven unpublished studies from systematic reviews 20 23 that had the potential to examine the relation between childhood care and adult CVD. In combination, this resulted in 13 unique datasets.…”

Section: Resultsmentioning

confidence: 99%

“…Second, with the aim of identifying unpublished studies with the potential to address the present research question, we scrutinised reviews of the impact of childhood state care on related adult health outcomes. 20,23 In composing this manuscript, we followed the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines for content. 24…”

Section: Methodsmentioning

confidence: 99%

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Cardiovascular Disease Events in Adults with a History of State Care in Childhood: Pooling of Unpublished Results from 9 Cohort Studies

Batty,

Kivimäki,

Almquist

et al. 2024

Preprint

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Background: Individuals who were separated from their biological family and placed into the care of the state during childhood (out-of-home care) are more prone to developing selected physical and mental health problems in adulthood, however, their risk of cardiovascular disease (CVD) is uncertain. Accordingly, we pooled published and unpublished results from cohort studies of childhood care and adult CVD. Methods: We used two approaches to identifying relevant data on childhood care and adult CVD (PROSPERO registration CRD42021254665). First, to locate published studies, we searched PubMed (Medline) until November 2023. Second, with the aim of identifying unpublished studies with the potential to address the present research question, we scrutinised retrieved reviews of the impact of childhood state care on related adult health outcomes. All included studies were required to have prospective measurement of state care in childhood and a follow-up of CVD events in adulthood as the primary outcome (incident coronary heart disease and/or stroke). Collaborating investigators provided study-specific estimates which were aggregated using random-effects meta-analysis. The Newcastle-Ottawa Scale was used to assess individual study quality. Findings: Thirteen studies (2 published, 11 unpublished) met the inclusion criteria, and investigators from nine provided viable results, including updated analyses of the published studies. Studies comprised 611,601 individuals (301,129 women) from the US, UK, Sweden, Finland, and Australia. Relative to the unexposed, individuals with a care placement during childhood had a 50% greater risk of CVD in adulthood (summary rate ratio after basic adjustment [95% confidence interval]: 1.50 [1.22, 1.84]); range of study-specific estimates: 1.28 to 2.06; I2 = 69%, p = 0.001). This association was attenuated but persisted after multivariable adjustment for socioeconomic status in childhood (8 studies; 1.41 [1.15, 1.72]) and adulthood (9 studies, 1.28 [1.10, 1.50]). There was a suggestion of a stronger state care-CVD association in women. Interpretation: Our findings show that individuals with experience of state care in childhood have a moderately raised risk of CVD in adulthood. For timely prevention, clinicians and policy makers should be aware that people with a care history may need additional attention in risk factor management.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Cardiovascular Disease Events in Adults with a History of State Care in Childhood: Pooling of Unpublished Results from 9 Cohort Studies

Batty,

Kivimäki,

Almquist

et al. 2024

Preprint

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“…1 ). Additionally, using citations in published systematic reviews, 18 , 33 we identified ten unpublished studies that had the potential to examine the relation between childhood care and adult cardiovascular disease. In combination, this resulted in 12 seemingly unique datasets.…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular disease in adults with a history of out-of-home care during childhood: a systematic review and meta-analysis of prospective cohort studies

Batty,

Kivimäki,

Almquist

et al. 2024

The Lancet Regional Health - Europe

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“…Research suggests a potential association between early childhood behaviors and psychiatric illness with adult obesity and BMI gain [38][39][40], while other research suggests that ACEs are associated with a range of childhood emotional and behavioral problems [41,42]. A recent literature review examining the associations between parental separation and cardiometabolic disease, noted that childhood psychosocial problems may act as a mediating or moderating mechanism [43]. This body of research is suggestive, in the light of the association between ACEs and cardiometabolic disease discussed above, that behavioral problems associated with parental imprisonment may moderate cardiometabolic disease risk in later life.…”

Section: Introductionmentioning

confidence: 99%

Parental imprisonment, childhood behavioral problems, and adolescent and young adult cardiometabolic risk: Results from a prospective Australian birth cohort study

Roettger,

Tan,

Houle

et al. 2023

Preprint

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Objectives Recent studies have demonstrated that parental imprisonment (PI) is associated with cardiometabolic risk later in life. However, underlying risk factors for these associations have not previously been explored. The present study examines how early childhood behaviors and parental imprisonment may be associated with cardiometabolic risk in adulthood. Methods The study follows a subset of 7,223 live, singleton births from 1981–1984 in Brisbane, Australia where data was collected on parental imprisonment at ages 5 & 14 and behaviors from the Child Behavioral Checklist (CBCL) at age 5. Our sample examines 1884 males and 1758 females whose mothers completed prenatal, age 5, and age 14 interviews and respondents completed one or more interviews at ages 14, 21, and 30. Multivariate regression was used to examine cross-sectional results, while individual growth models examined longitudinal patterns. Results Dividing analysis by sex, we examined how parental imprisonment was potentially mediated or moderated by CBCL subscale measures for aggression, social-attention-thought disorders and general internalizing. No associations were found among male respondents. Among female respondents, controlling for these behaviors, there was a significant association between parental imprisonment and higher systolic blood pressure at age 30, while all CBCL measures were found to moderate waist circumference at age 30 and BMI at ages 14, 21, and 30. Using individual growth curve modelling, we observed the increased CBCL aggression and SAT scores were more strongly associated with higher BMI in adulthood. Conclusions Using prospective cohort data, our results suggest that PI and high levels of behavioral problems are associated with significantly increased cardiometabolic risk in women, with potentially increasing risk in adulthood.

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Parent-child separation and cardiometabolic outcomes and risk factors in adulthood: A systematic review

Cited by 5 publications

References 50 publications

Cardiovascular Disease Events in Adults with a History of State Care in Childhood: Pooling of Unpublished Results from 9 Cohort Studies

Cardiovascular Disease Events in Adults with a History of State Care in Childhood: Pooling of Unpublished Results from 9 Cohort Studies

Cardiovascular disease in adults with a history of out-of-home care during childhood: a systematic review and meta-analysis of prospective cohort studies

Parental imprisonment, childhood behavioral problems, and adolescent and young adult cardiometabolic risk: Results from a prospective Australian birth cohort study

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