Parent pain catastrophizing predicts child depressive symptoms in youth with sickle cell disease

Goldstein-Leever, Alana; Cohen, Lindsey L.; Dampier, Carlton

doi:10.1002/pbc.27027

Cited by 19 publications

(33 citation statements)

References 46 publications

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“…32 Parent catastrophizing may influence the pain experience of children with SCD 33 and significantly contribute to their depressive symptoms. 34,35 These studies highlight the bidirectional link between mental illness and pain, with both conditions mutually reinforcing one another.…”

Section: Psychiatric Disorders and Chronic Painmentioning

confidence: 92%

Optimizing the management of chronic pain in sickle cell disease

2020

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Chronic pain in sickle cell disease (SCD) refers to pain present on most days lasting over six months. It can start during childhood and the prevalence increases with age. By adulthood, over 55% of patients experience pain on over 50% of days; 29% reporting pain on 95% of days. The true prevalence of chronic pain in SCD is likely underappreciated as it is mostly managed at home. Patients with chronic pain and SCD frequently seek acute care for exacerbation of underlying chronic pain difficult to distinguish from their usual acute vaso-occlusive crises. When treating chronic pain in SCD, the challenge is distinguishing between non-SCD related etiologies versus chronic pain resulting from SCD pathophysiological processes. This distinction is important to delineate as it will drive appropriate management strategies. Chronic pain in SCD has profound consequences for the patient; is often associated with comorbid psychiatric illnesses (depression and anxiety), not dissimilar from other chronic pain syndromes. They may also experience challenges with sleep hygiene, various somatic symptoms, and chronic fatigue that impair quality of life. How best to treat chronic pain in SCD is not definitively established. Both acute and chronic pain in SCD is typically treated with opioids. Emerging data suggests that chronic opioid therapy (COT) is a suboptimal treatment strategy for chronic pain. This review will discuss the complexity of managing chronic pain in SCD; pain that may be dependent or independent of the underlying SCD diagnosis. We will also describe alternative treatment approaches to high-dose COT.

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Section: Psychiatric Disorders and Chronic Painmentioning

confidence: 92%

Optimizing the management of chronic pain in sickle cell disease

2020

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“…Across studies that examined the relationship between pain and depressive symptoms, there was significant variability in levels of depressive symptoms. For studies examining pain frequency, intensity, or pain coping, the percentage of youth with clinically significant cut-off scores on depressive measures ranged from 4 to 27% (Barakat, Schwartz, Simon, & Radcliffe, 2007;Goldstein-Leever, Cohen, Dampier, & Sil, 2018;Hoff, Palermo, Schluchter, Zebracki, & Drotar, 2006;Palermo, Platt-Houston, Kiska, & Berman, 2005).…”

Section: Depressive Symptomsmentioning

confidence: 99%

Systematic Review: Pain and Emotional Functioning in Pediatric Sickle Cell Disease

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Rockman

Okonak

et al. 2019

J Clin Psychol Med Settings

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The objective of this systematic review was to assess the relationship between pain (frequency/intensity/duration, impairment, coping) and emotional functioning in pediatric Sickle Cell Disease, and evaluate the state of the literature. Studies were included if they met each of the following criteria: (a) primarily pediatric sample of youth or young adults up to age 21 years with SCD, (b) examined emotional functioning including anxiety and/or depressive and/or internalizing symptoms, and/or affect, (c) examined pain intensity/frequency/duration and/or pain-related impairment and/or pain coping as it relates to emotional functioning, as defined above. Using the established guidelines for systematic reviews, we searched PsycINFO, PubMED, and CINAHL databases for studies published through June 2018. Screening resulted in 33 studies meeting inclusion criteria. Study data were extracted and evaluated for scientific merit, resulting in four studies being removed. 29 studies were included in the final synthesis. Studies provide strongest evidence of a relationship between increased pain frequency and higher depressive and anxiety symptoms. There are moderate-to-strong associations between pain-related impairment and depressive symptoms, and small-to-strong associations between pain-related impairment and anxiety. When examining pain-coping strategies, maladaptive cognitive strategies show the strongest association with emotional functioning. There is a need for more adequately powered, prospective studies based on theoretical frameworks in order to advance our understanding of the relationship between pain and emotional functioning in pediatric SCD.

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“…Data reported by patients are important data to collect in patients with SCD. Indeed, patients’ poor perception of quality of life can lead to depressive symptoms, which are themselves risk factors, particularly in children, for chronic pain [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Goldstein-Leever et al have shown a link between parents’ perception of pain and children’s perception of pain in SCD. Parents’ catastrophizing about their child’s pain contributed to child’s depressive symptoms, symptoms that have been identified as risk factors for chronic SCD pain [ 41 ]. Parental health and parenting beliefs and behaviours are known to have a significant impact on child pain management, and parental emotional distress and depression represent an independent risk factor for adverse child outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

et al. 2021

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Background Sickle cell disease (SCD) induces chronic haemolytic anaemia and intermittent vaso-occlusion that results in tissue ischaemia causing acute, severe pain episodes that can lead to frequent hospitalizations. These consequences can have repercussions on family, social, school and/or professional life. Here, we present some of the results of the PHEDRE study (Pharmacodépendance Et DREpanocytose—drug dependence and sickle-cell disease), which is the largest study of patients with SCD in France. This paper intends to describe characteristics of the French SCD population. We also aimed to assess the impact of the disease on the lives of patients using objective and subjective variables. Methods The PHEDRE study was a national multicentric observational study. Adults, adolescents and children with a confirmed SCD diagnosis were included in the study by their referring doctor. Then, they were interviewed by phone about their socioeconomic status, about the impact of the disease on their lives and about their analgesic and psychoactive drug use. Results The study population consisted of 872 patients (28% were minors). Seventy-two percent of adults were active, and all minors were in school. Many patients presented criteria of severe SCD. Seventy-five percent were homozygous SS, 15% were double heterozygotes SC and 8% were heterozygotes Sβthal, 87% received specific treatment, 58% were hospitalized at least once for vaso-occlusive crisis in the past 12 months, and the number of analgesic drugs taken averaged 3.8. Seventy-five percent of patients reported academic or professional consequences related to their SCD, and 52% reported social consequences. Conclusions The impact of SCD on patients’ lives can be significant, nevertheless their social integration seems to be maintained. We highlighted respect of recommendations regarding analgesic treatments and only a few patients used tobacco, alcohol or cannabis. Trial registration Clinical Trials, NCT02580565; https://clinicaltrials.gov/ Registered 16 October 2015.

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Parent pain catastrophizing predicts child depressive symptoms in youth with sickle cell disease

Abstract: Findings support the value of depression screening and interventions to promote parent self-efficacy in managing childhood SCD pain.

Cited by 19 publications

References 46 publications

Optimizing the management of chronic pain in sickle cell disease

Optimizing the management of chronic pain in sickle cell disease

Systematic Review: Pain and Emotional Functioning in Pediatric Sickle Cell Disease

Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

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