Parental acceptance of an intranasal vaccine: Example of influenza vaccine

Marien, A.-G.; Hochart, Audrey; Lagrée, M.; Diallo, D.; Martinot, A.; Dubos, François

doi:10.1016/j.arcped.2018.11.002

Cited by 14 publications

(11 citation statements)

References 17 publications

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“…29 39 40 However, no such acceptance rate has been evaluated among HCWs. 41 It is interesting to note that, of all the HCW respondents asked about taking a COVID-19 vaccine, only 20% or 24% preferred to receive the AstraZeneca or the Pfizer vaccine, respectively. This low response to acceptance of any vaccine in development may indicate variability in the knowledge and understanding about the different vaccines.…”

Section: Discussionmentioning

confidence: 99%

Adenovirus and RNA-based COVID-19 vaccines’ perceptions and acceptance among healthcare workers in Saudi Arabia: a national survey

et al. 2021

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ObjectivesThe aim of this study was to compare the perception, confidence, hesitancy and acceptance rate of various COVID-19 vaccine types among healthcare workers (HCWs) in Saudi Arabia, a nation with Middle East respiratory syndrome coronavirus experience.DesignNational cross-sectional, pilot-validated questionnaire.SettingOnline, self-administered questionnaire among HCWs.ParticipantsA total of 2007 HCWs working in the Kingdom of Saudi Arabia participated; 1512 (75.3%) participants completed the survey and were included in the analysis.InterventionData were collected through an online survey sent to HCWs during 1–15 November 2020. The main outcome measure was HCW acceptance of COVID-19 candidate vaccines. The associated factors of vaccination acceptance were identified through a logistic regression analysis and via measurement of the level of anxiety, using the Generalised Anxiety Disorder 7 scale.ResultsAmong the 1512 HCWs who were included, 62.4% were women, 70.3% were between 21 and 40 years of age, and the majority (62.2%) were from tertiary hospitals. In addition, 59.5% reported knowing about at least one vaccine; 24.4% of the participants were sure about their willingness to receive the ChAdOx1 nCoV-19 vaccine, and 20.9% were willing to receive the RNA BNT162b2 vaccine. However, 18.3% reported that they would refuse to receive the Ad5-vectored vaccine, and 17.9% would refuse the Gam-COVID-Vac vaccine. Factors that influenced the differential readiness of HCWs included their perceptions of the vaccine’s efficiency in preventing the infection (33%), their personal preferences (29%) and the vaccine’s manufacturing country (28.6%).ConclusionsAwareness by HCWs of the several COVID-19 candidate vaccines could improve their perceptions and acceptance of vaccination. Reliable sources on vaccine efficiency could improve vaccine uptake, so healthcare authorities should use reliable information to decrease vaccine hesitancy among frontline healthcare providers.

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Section: Discussionmentioning

confidence: 99%

Adenovirus and RNA-based COVID-19 vaccines’ perceptions and acceptance among healthcare workers in Saudi Arabia: a national survey

et al. 2021

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“…The vaccine is delivered directly to the mucosal surface, and this should enhance mucosal cellular and humoral immune responses [ 9 , 10 ]. Individuals with direct experience with intranasal vaccination tend to favor it over needle injection, as it is considered less painful and less intrusive to the body, equally effective, and associated with fewer side effects [ 11 , 12 , 13 ]. For example, previous studies have found that the majority of children aged 8–12 years selected mode of administration as one of the most important vaccine attributes, preferring the nasal spray rather than the needle [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, previous studies have found that the majority of children aged 8–12 years selected mode of administration as one of the most important vaccine attributes, preferring the nasal spray rather than the needle [ 12 ]. Even parents’ global opinion and tolerance were judged to be better for intranasal than for intramuscular injection, and they have declared to prefer the LAIV for future vaccination of their children [ 13 ]. Additional studies have shown that this mode of administration is also effective and well-accepted among the adult population aged 18–70 years old [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy

et al. 2023

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Little is known about the use of intranasal vaccines, but some studies have shown that this innovative way of administration is preferred over needle injection as it is considered both less painful and intrusive to the body, equally effective, and associated with fewer side effects. This study aimed to investigate specific psychological determinants (intolerance of uncertainty, persecutory ideation, perceived control, vaccine hesitancy) of attitude toward nasal vaccine delivery. A convenience sample including 700 Italian participants took part in this cross-sectional study and completed an online questionnaire. A structural equation model with a latent variable was performed to study the relationship between psychological variables, vaccine hesitancy, and attitude toward nasal vaccine delivery. The results indicate that both a hesitant attitude toward vaccination (β = 0.20, p = 0.000) and low perceived control (β = −0.20, p = 0.005) may directly increase preference for nasal administration; furthermore, high levels of persecutory ideation may indirectly influence the propensity for intranasal vaccine. These findings suggest that pharmaceutical companies could implement nasal vaccines and provide detailed information on these vaccines through informational campaigns. Hesitant individuals with low levels of perceived control could more easily comply with these types of vaccines.

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“…F i g u r e 2 : T h e p e r c e n t a g e o f H C W w i l l i n g t o r e c i e v e B N T 1 6 2 b 2 v a c c i n e p o s t i t s e f f i c a c y a n n o u n c e m e influenza vaccine [36]; however no such acceptance rate has been evaluated among HCWs. [37] It is interesting to note that, of all the HCW respondents asked about taking a COVID Many factors affect the choice to receive vaccines. In this study, the top reason for choosing a vaccine was that the vaccine seems more effective at preventing infection (33%).…”

Section: Resultsmentioning

confidence: 99%

“…In a parental survey on acceptance of an intranasal, live, attenuated influenza vaccine, 81% preferred this version compared with the injectable inactivated influenza vaccine[36]; however no such acceptance rate has been evaluated among HCWs. [37]…”

Section: Discussionmentioning

confidence: 99%

Adenovirus and RNA-based COVID-19 vaccines: perceptions and acceptance among healthcare workers

Temsah

Barry

Aljamaan

et al. 2020

Preprint

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ObjectivesThe aim of this study was to compare the perception, confidence, hesitancy, and acceptance rate of various COVID-19 vaccine types among healthcare workers (HCWs) in Saudi Arabia, a nation with MERS-CoV experience.DesignNational cross-sectional, pilot-validated questionnaire.SettingOnline, self-administered questionnaire among HCWs.ParticipantsA total of 2,007 HCWs working in the Kingdom of Saudi Arabia participated; 75.3% completed the survey and were included in the analysis.InterventionData were collected through an online survey sent to HCWs during November 1-15, 2020. The main outcome measure was HCW acceptance of COVID-19 candidate vaccines. The associated factors of vaccination acceptance were identified through a logistic regression analysis and via measurement of the level of anxiety, using the generalized anxiety disorder 7 (GAD7) scale.ResultsAmong the 1512 HCWs who were included, 62.4% were women, 70.3% were between 21 and 40 years of age, and the majority (62.2%) were from tertiary hospitals. In addition, 59.5% reported knowing about at least one vaccine; 24.4% of the participants were sure about their willingness to receive the ChAdOx1 nCoV-19 vaccine, and 20.9% were willing to receive the RNA BNT162b2 vaccine. However, 18.3% reported that they would refuse to receive the Ad5-vectored vaccine, and 17.9% would refuse the Gam-COVID-Vac vaccine. Factors that influenced the differential readiness of HCWs included their perceptions of the vaccine’s efficiency in preventing the infection (33%), their personal preferences (29%), and the vaccine’s manufacturing country (28.6%).ConclusionsAwareness by HCWs of the several COVID-19 candidate vaccines could improve their perceptions and acceptance of vaccination. Reliable sources on vaccine efficiency could improve vaccine uptake, so healthcare authorities should use reliable information to decrease vaccine hesitancy among frontline healthcare providers.

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Parental acceptance of an intranasal vaccine: Example of influenza vaccine

Cited by 14 publications

References 17 publications

Adenovirus and RNA-based COVID-19 vaccines’ perceptions and acceptance among healthcare workers in Saudi Arabia: a national survey

Adenovirus and RNA-based COVID-19 vaccines’ perceptions and acceptance among healthcare workers in Saudi Arabia: a national survey

Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy

Adenovirus and RNA-based COVID-19 vaccines: perceptions and acceptance among healthcare workers

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