Parental-Age Effects: Increased Frequencies of Genetically Abnormal Offspring

Kram, David; Schneider, Edward L.

doi:10.1007/978-1-4684-2445-4_9

Cited by 7 publications

(6 citation statements)

References 97 publications

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“…Interest in the meiotic changes during ageing has been intensified in the perspective of identifying chromosome disorders related to parental age (Kram and Schneider 1978). In mice and rats, some experiments have been carried out on the alterations in sperm morphology.…”

Section: Discussionmentioning

confidence: 99%

Chromosomal alterations and DNA content in rats during ageing

Sen

Talukder²,

Sharma³

1989

Genome

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Chromosome analysis of bone marrow cells from 96 sex-matched Rattus norvegicus of 12 different age groups showed a significant increase in hypodiploid cells with ageing. However, in meiotic preparations from gonadal cells of male rats the frequency of hypodiploid or hyperdiploid cells did not change significantly. In situ DNA estimation of bone marrow nuclei, following Feulgen cytophotometry, also did not show any significant difference with gradual age changes.

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Section: Discussionmentioning

confidence: 99%

Chromosomal alterations and DNA content in rats during ageing

Sen

Talukder²,

Sharma³

1989

Genome

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“…In particular, there is welldocumented evidence of both maternal and paternal age effects in the frequency of genetic abnormalities in human offspring (Vogel and Rathenberg 1975;Kram and Schneider 1978).…”

Section: Ageing In Germ Cells'mentioning

confidence: 99%

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

1982

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Summary. Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential. Weismann's prediction was derived by considering the role of natural selection in regulating the duration of an organism's life. For various reasons, Weismann's ideas on ageing fell into neglect following his death in 1914, and cytogerontology has only reappeared as a major research area following'the demonstration by Hayflick and Moorhead in the early 1960s that diploid human fibroblasts are restricted to a finite number of divisions in vitro.In this review we give a detailed account of Weismann's theory, and we reveal that his ideas were both more extensive in their scope and more pertinent to current research than is generally recognised. We also appraise the progress which has been made over the past hundred years in investigating the causes of ageing, with particular emphasis being given to (i) the evolution of ageing, and (ii) ageing at the cellular level. We critically assess the current state of knowledge in these areas and recommend a series of points as primary targets for future research.

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“…To-date, a large amount of information has been accumulated on that advanced parental age could be related to the increased frequency of these conditions (Makino 1975;Kram and Schneider 1978).…”

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confidence: 99%

“…Maternal-age-related disorders are well-defined from paternal-agedependent ones showing diverse etiologies. Almost all maternal-agerelated disorders are characterized by trisomic conditions of certain chromosomes, while most conditions related to paternal aging appear as autosomal dominant disorders which are inherited in an autosomal dominant manner (Kram and Schneider 1978).…”

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confidence: 99%